Navigation Links
Scientists get first glimpse at how plants, most animals repair UV-damaged DNA

For the first time, researchers have observed exactly how some cells are able to repair DNA damage caused by the sun's ultraviolet (UV) radiation.

The Ohio State University study revealed how the enzyme photolyase uses energy from visible light to repair UV damage.

This enzyme is missing in all mammals, including humans, although all plants and all other animals have it. Greater understanding of how photolyase works could one day lead to drugs that help repair UV damage in human DNA.

In the online edition of the Proceedings of the National Academy of Sciences, Dongping Zhong and his colleagues report experimental evidence of what scientists have long suspected -- that visible light excites the photolyase molecule and boosts the energy of electrons in its atoms. This in turn enables the enzyme to inject an electron into the DNA molecule at the UV damage site temporarily to perform repairs.

They also report something that was unexpected: Water plays a key role in the process, by regulating how long the donated electron stays inside the damage site before returning to the photolyase molecule.

Scientists believe that all placental mammals lost the ability to make this enzyme some 170 million years ago, said Zhong, an assistant professor of physics and adjunct assistant professor of chemistry and biochemistry at Ohio State.

That's why humans, mice, and all other mammals are particularly vulnerable to cancer-causing UV rays from the sun. But the rest of the animal kingdom ?insects, fish, birds, amphibians, marsupials, and even bacteria, viruses and yeast ?retained a greater ability to repair such damage.

Since the 1940s, scientists have been trying to understand how the DNA in plants and some animals can be damaged by UV light, and then ?seemingly ?repaired by visible light. In the 1960s, they identified the enzyme that was responsible for the repair, and named it photolyase, but they didn't know exactly how the enzym
'"/>

Source:Ohio State University


Page: 1 2 3

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
(Date:5/23/2013)... Laboratory honored more than 165 staff for their ... PNNL,s annual Intellectual Property Commercialization Recognition & Rewards ... national laboratory named materials scientist Jun Liu Inventor ... materials that can store large amounts of energy, ... the time it takes to charge cell phones, ...
(Date:5/23/2013)... The tight wrapping of genomic DNA around nucleosomes ... gene expression. A team of Ludwig-Maximilians-Universitaet (LMU) in ... DNA to be locally displaced from nucleosomes for ... is stored in the cell nucleus, wrapped around ... pairs of four different histone proteins and accommodating ...
(Date:5/23/2013)... cerebral palsy with autologous cord blood. Following a cardiac ... boy had been in a persistent vegetative state ... treatment with the cord blood containing stem cells, the ... learned to speak simple sentences and to move. "Our ... the long-held doubts about the effectiveness of the new ...
Breaking Biology News(10 mins):PNNL staff recognized for scientific accomplishments, moving technologies into the marketplace 2Biochemistry: Unspooling DNA from nucleosomal disks 2First successful treatment of pediatric cerebral palsy with autologous cord blood 2
... and diesel with plant-based bio fuels is crucial to curb climate ... and some of the methods result in bio fuels that are ... from the University of Copenhagen shows that it is possible to ... single drop. This promises cheaper, faster and above all safer development ...
... usually progresses in small steps, but on rare occasions, ... produces a ,great leap forward., An international team of ... Joseph Ecker, report one such leap in the July ... their mapping and early analyses of thousands of protein-to-protein ...
... 29, 2011Intravenous delivery of cold fluids to reduce body ... outcomes may not be as effective in children as ... in Therapeutic Hypothermia and Temperature Management , a ... article is available free online at www.liebertpub.com/ther ...
Cached Biology News:Computational chemistry shows the way to safer biofuels 2Scientists take a giant step for people -- with plants! 2Scientists take a giant step for people -- with plants! 3Scientists take a giant step for people -- with plants! 4
(Date:5/24/2013)... and TEL AVIV, Israel , May ... the "Company") (NYSE MKT: NSPR), a leader in embolic protection ... Company,s President and Chief Executive Officer, and Craig ... in the Benchmark Company, LLC One-on-One Investor Conference on Thursday ... Ave., Milwaukee, WI. The ...
(Date:5/24/2013)... Oklahoma City, OK (PRWEB) May 24, 2013 ... handful of casualties. And following its ravage, the mayor of ... room bill for new houses, said a report from cnn.com. ... offered the tornado victims complimentary Molderizer and Safe Shield to ... according to the report published on May 22, 2013, caused ...
(Date:5/23/2013)... Mich. Every day, their baby stopped breathing, his ... his lungs. April and Bryan Gionfriddo watched helplessly, just ... "Quite a few doctors said he had a good ... Gionfriddo, about her now 20-month-old son, Kaiba. "At that ... would take it and run with it." , They ...
(Date:5/23/2013)... Graphite Metallizing Corporation announces a series ... stainless steel pillow blocks. This series combines the ... application and installation versatility of pillow blocks. , ... exceptionally well when submerged in water, water-soluble chemicals ... acids, alkalies, hydrocarbons, black liquor, and liquid gases. ...
Breaking Biology Technology:InspireMD To Participate In Benchmark Investor Conference On May 30th 2InspireMD To Participate In Benchmark Investor Conference On May 30th 3InspireMD To Participate In Benchmark Investor Conference On May 30th 4Mayor of Oklahoma-Tornado-Impaired Town Proposes Storm Shelter Bill, My Cleaning Products Offers Complimentary Molderizer and Safe Shield to Help Victim with Looming Mold 2Baby's life saved with groundbreaking 3-D printed device that restored his breathing 2Baby's life saved with groundbreaking 3-D printed device that restored his breathing 3Graphite Metallizing Now Offers GRAPHALLOY® Stainless Steel Pillow Blocks for Success in Submersible Applications 2Graphite Metallizing Now Offers GRAPHALLOY® Stainless Steel Pillow Blocks for Success in Submersible Applications 3
... 2011 Orexigen® Therapeutics, Inc. (Nasdaq: OREX ), ... the Company,s workforce, resulting in a reduction in staff of ... due to the Complete Response Letter it received from the ... on January 31, 2011 regarding the New Drug Application (" ...
... ERES ) announced today that it will release its ... March 1, after the market closes. After the release, the ... that day. For the conference call, interested ... or 1-412-858-4600 when calling internationally. There will be a playback ...
... HIGHLIGHTS:2010 Results (all percentages are to comparable periods in ... million, a new quarterly high. Q4 sales grew by 2% and ... 2010 sales increased 6% and 5% on a reported and currency ... EPS was $0.76. Excluding restructuring costs of $0.07, adjusted Q4 2010 ...
Cached Biology Technology:Orexigen® Therapeutics Announces Corporate Realignment 2Orexigen® Therapeutics Announces Corporate Realignment 3ERT Reports Fourth Quarter and Full Year 2010 Operating Results on March 1, 2011 2Sigma-Aldrich (Nasdaq: SIAL) Reports Q4 and Full Year 2010 Diluted EPS of $0.76 and $3.12, Respectively. Q4 and Full Year 2010 Adjusted Diluted EPS Were $0.83 and $3.31, Respectively. Q4 Sales Set New Quarterly High. 2011 Diluted EPS Expected to be 2Sigma-Aldrich (Nasdaq: SIAL) Reports Q4 and Full Year 2010 Diluted EPS of $0.76 and $3.12, Respectively. Q4 and Full Year 2010 Adjusted Diluted EPS Were $0.83 and $3.31, Respectively. Q4 Sales Set New Quarterly High. 2011 Diluted EPS Expected to be 3Sigma-Aldrich (Nasdaq: SIAL) Reports Q4 and Full Year 2010 Diluted EPS of $0.76 and $3.12, Respectively. Q4 and Full Year 2010 Adjusted Diluted EPS Were $0.83 and $3.31, Respectively. Q4 Sales Set New Quarterly High. 2011 Diluted EPS Expected to be 4Sigma-Aldrich (Nasdaq: SIAL) Reports Q4 and Full Year 2010 Diluted EPS of $0.76 and $3.12, Respectively. Q4 and Full Year 2010 Adjusted Diluted EPS Were $0.83 and $3.31, Respectively. Q4 Sales Set New Quarterly High. 2011 Diluted EPS Expected to be 5Sigma-Aldrich (Nasdaq: SIAL) Reports Q4 and Full Year 2010 Diluted EPS of $0.76 and $3.12, Respectively. Q4 and Full Year 2010 Adjusted Diluted EPS Were $0.83 and $3.31, Respectively. Q4 Sales Set New Quarterly High. 2011 Diluted EPS Expected to be 6Sigma-Aldrich (Nasdaq: SIAL) Reports Q4 and Full Year 2010 Diluted EPS of $0.76 and $3.12, Respectively. Q4 and Full Year 2010 Adjusted Diluted EPS Were $0.83 and $3.31, Respectively. Q4 Sales Set New Quarterly High. 2011 Diluted EPS Expected to be 7Sigma-Aldrich (Nasdaq: SIAL) Reports Q4 and Full Year 2010 Diluted EPS of $0.76 and $3.12, Respectively. Q4 and Full Year 2010 Adjusted Diluted EPS Were $0.83 and $3.31, Respectively. Q4 Sales Set New Quarterly High. 2011 Diluted EPS Expected to be 8Sigma-Aldrich (Nasdaq: SIAL) Reports Q4 and Full Year 2010 Diluted EPS of $0.76 and $3.12, Respectively. Q4 and Full Year 2010 Adjusted Diluted EPS Were $0.83 and $3.31, Respectively. Q4 Sales Set New Quarterly High. 2011 Diluted EPS Expected to be 9Sigma-Aldrich (Nasdaq: SIAL) Reports Q4 and Full Year 2010 Diluted EPS of $0.76 and $3.12, Respectively. Q4 and Full Year 2010 Adjusted Diluted EPS Were $0.83 and $3.31, Respectively. Q4 Sales Set New Quarterly High. 2011 Diluted EPS Expected to be 10Sigma-Aldrich (Nasdaq: SIAL) Reports Q4 and Full Year 2010 Diluted EPS of $0.76 and $3.12, Respectively. Q4 and Full Year 2010 Adjusted Diluted EPS Were $0.83 and $3.31, Respectively. Q4 Sales Set New Quarterly High. 2011 Diluted EPS Expected to be 11Sigma-Aldrich (Nasdaq: SIAL) Reports Q4 and Full Year 2010 Diluted EPS of $0.76 and $3.12, Respectively. Q4 and Full Year 2010 Adjusted Diluted EPS Were $0.83 and $3.31, Respectively. Q4 Sales Set New Quarterly High. 2011 Diluted EPS Expected to be 12Sigma-Aldrich (Nasdaq: SIAL) Reports Q4 and Full Year 2010 Diluted EPS of $0.76 and $3.12, Respectively. Q4 and Full Year 2010 Adjusted Diluted EPS Were $0.83 and $3.31, Respectively. Q4 Sales Set New Quarterly High. 2011 Diluted EPS Expected to be 13
RAT ANTI MOUSE TCR V BETA 7:RPE Immunogen: T-cell lymphoma TK1...
ANTI S. ENT TOX BC2D...
... Anti-Major DNA-binding protein(DBP). Protein size: ... NP_001343 ELISA titre using peptide ... conditions for Western Blot: 1.0g/ml ... and HRP conjugated anti-Rabbit IgG should be ...
Collected from sexually mature, mixed sex, mixed breed guinea pigs. Pricing: $120/unit for 1 - 10 units...
Biology Products: