Navigation Links
Scientists find potential 'off-switch' for HIV virus

uit exists -- not an electrical circuit, but a set of chemical reactions that runs in a loop. First, one of HIV's genes creates the Tat protein, which is part of the chemical signal for the virus to begin replicating. An important player to complete the signal is an enzyme within the T cell called p300 that decorates the Tat protein with a small chemical tail. The p300 enzyme converts the Tat protein into a message that activates the virus and creates more Tat protein, and eventually converts the T cell into an active HIV factory.

"The more of these [messages] sensed within the cell, the more Tat proteins the gene creates, resulting in a snowball effect that is difficult to stop," Weinberger said of the onset of full-blown infection.

Mechanisms do exist to halt the process, however. For example, another enzyme within the affected cell called SirT1 is capable of pulling the chemical tail off the Tat protein, rendering it silent. The interplay between p300 and SirT1 comprises the resistor and can effectively keep the virus in its dormant phase.

"SirT1 reduces the strength of the signal to replicate," Weinberger said. "It may prove to be the key part of the resistor in the circuit, as our mathematical models are strongly suggesting."

Not all the molecular players are known yet, nor how their relative roles determine whether the virus becomes dormant, but Weinberger said his and Shenk's results lead them to think they are on the right track. If their theories prove correct, they could form the basis for therapies that combat HIV and other viruses that possess these genetic circuits within their own DNA.

"SirT1 and related processes might eventually turn off viral activation in T cells all by themselves, but the cell is usually dead before it can happen," Weinberger said. "If we can create drugs that target these enzymes, perhaps we can get SirT1 and related enzymes to assert themselves immediately, forcing HIV into h
'"/>

Source:Princeton University


Page: 1 2 3 4

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Scientists find potential off switch for HIV virus

(Date:4/9/2015)... 2015 Synaptics Inc. (NASDAQ: SYNA ), a ... it will report financial results for the third quarter ... the close of market. The company will host a ... p.m. PT (5:00 p.m. ET), during which management may ... the live call, analysts and investors should dial 888-438-5524 ...
(Date:4/6/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... on the growing mobile commerce market, announced today ... MINIATURE, MULTI-PURPOSE ANTENNA METHOD AND SYSTEM FOR ... introduces a new revolutionary method and system to ... of miniature antenna modules for multiple purposes including ...
(Date:4/2/2015)... -- At its 2015 ACMG Annual Clinical Genetics Meeting ... American College of Medical Genetics and Genomics (ACMG) announced ... Members of the ACMG Board of Directors serve as ... its policies and programs. ACMG is the national organization ... eventful time in medical genetics and genomics.  We are ...
Breaking Biology News(10 mins):Synaptics to Report Third Quarter Results on April 23 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8
... YORK, NY (January 21) - New York Stem Cell Foundation ... is lead author on a study defining conditions for generating ... suitable for therapeutic use. Dr. James and his colleagues ... can be used to measure endothelial cell production and activity. ...
... Raymond Mendez, the "original insect wrangler" who tamed 25,000 ... the movie "Silence of the Lambs," headlines the Southwest,s ... the Desert Botanical Garden. Designed for inquiring minds ... top scientists from Arizona State University, their favorite critters ...
... professor of chemistry and biochemistry Brian Baker and his research ... of dynamic motion by proteins involved in the body,s immune ... , the leading research journal in the field of immunology. ... system,s T-cells are important for discovering and destroying cells that ...
Cached Biology News:NYSCF Fellow lead author on study that creates blood vessel cells from stem cells 2Insect wranglers invade the garden at Southwestern science EXPO 2Notre Dame study focuses on protein dynamics 2
(Date:5/26/2015)... mája 2015 Kevin Xu , ... prezidentom Barackovi Obamovi a Billovi Clintonovi za ich ... Dr. Rongxiang Xu , otca Kevina. ... Dr. Xu bol pionier, inovátor, humanitárny pracovník ... v oblasti vedy a príkladné vedenie svojej komunity ...
(Date:5/26/2015)... May 26, 2015  Asterias Biotherapeutics, Inc. (NYSE MKT: ... of regenerative medicine, today announced that all outstanding common ... exercised prior to their expiry on June 15, 2015, ... million. "We thank our shareholders for their ... CEO of Asterias. "This exercise of warrants represents a ...
(Date:5/26/2015)... /PRNewswire/ - Fluorinov Pharma (Fluorinov), a FACIT portfolio company, ... to its Board of Directors.  His appointment strengthens ... as Fluorinov accelerates its clinical development activities.  ... a pleasure to welcome Luke to the Board of ... strategy, financial strength and success of multiple organizations," said ...
(Date:5/26/2015)... YORK , May 26, 2015 US-Australian drug discovery ... today that it will present at the 2015 Marcum MicroCap ... York City at the Grand Hyatt Hotel. ... Chairman and CEO, is scheduled to begin at 9.30 a.m. ET ... webcast, go to http://wsw.com/webcast/marcum3/nvgn . The annual ...
Breaking Biology Technology:Dr. Rongxiang Xu, O legende 2Asterias Biotherapeutics Receives $11.7 Million in Proceeds from Exercise of Warrants 2Asterias Biotherapeutics Receives $11.7 Million in Proceeds from Exercise of Warrants 3Luke M. Beshar Appointed to Fluorinov Pharma Board of Directors 2Luke M. Beshar Appointed to Fluorinov Pharma Board of Directors 3Novogen to Present at the 2015 Marcum Microcap Conference 2Novogen to Present at the 2015 Marcum Microcap Conference 3Novogen to Present at the 2015 Marcum Microcap Conference 4
... at the University of Pittsburgh have created the best ... single molecule wide, a significant step in science,s increasing ... to the single molecule scale and provide smaller, faster, ... online Sept. 26 in the Journal of the American ...
... is the wonder material for the computer age, carbon ... the next evolutionary step in electronics and computing. Their ... to revolutionise many technologies. , In particular, it ... devices to the next level. Many people expect the ...
... to make a composite material with more desirable properties ... the marine industry for decades and the construction industry ... are getting in on the act with nanotechnologists working ... an ideal manner. , Researchers from Trinity College ...
Cached Biology Technology:FED-TVs with carbon nanotube technology could supersede plasma and LCD flat screens 2
Anti-ZFP-38/RU49 Family: Zinc Finger Peptide Sequence: SVKVEDKDFPSTCSKK...
TRIzol Reagents are ready-to-use monophasic solutions of phenol and guanidine isothiocyanate suitable for isolating total RNA DNA and proteins (16)....
Antibodies were affinity purified using epitopes specific to UBAP2L/NICE4 immobilized on solid support....
... Biochain's plant total protein western ... rapidly screening tissue specific protein ... placenta total protein is included ... interblot control for comparison between ...
Biology Products: