Navigation Links
Scientists find new genes for Crohn's disease

ory evidence for what doctors have long suspected: that an individual's ability to respond effectively to harmful microbes influences his or her susceptibility to the disease.

"We propose that genetic variation in the ATG16L1 gene leads to alterations in how the body uses autophagy and therefore may result in increased persistence of [toxic] cellular and bacterial components. This may lead to an inappropriate immune activation and increased risk of Crohn's disease," says co-author Dr. Ramnik Xavier, a gastroenterologist at the Massachusetts General Hospital's (MGH) Center for the Study of IBD and a researcher at the MGH Center for Computational and Integrative Biology.

This study's findings are expected not only to improve on the biological understanding of disease but also should have a long-term impact on clinical practice, according to Dr. Steven Brant, co-author and gastroenterologist at Johns Hopkins University.

"The multiple genetic risk factors we've identified provide important targets for current functional studies aimed at understanding the disease. These will be important targets for drug development to improve therapy of Crohn's disease in the future," he said.

Stephen P. James, M.D., director of the division of digestive diseases and nutrition at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) agreed, saying that "these important discoveries not only offer new hope for better therapies for patients with Crohn's disease, but they also highlight the promise of the human genome project and subsequent investments by the NIH in large-scale, collaborative research projects to unravel the causes of, and hopefully better treatments for complex, enigmatic diseases".

In addition to finding the additional Crohn's disease susceptibility genes, the researchers got strong signals for genetic risk factors located in areas of the genome where there are no known genes. "Further work will be n
'"/>

Source:University of Pittsburgh Schools of the Health Sciences


Page: 1 2 3 4

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Scientists find new genes for Crohn disease

(Date:9/19/2014)... of Oklahoma biology professor will study the unique bioelectric ... could eventually benefit people,s health. The OU researcher ... energy required to produce the signals used to map ... signals at a rate of 500-600 discharges a second ... the electric fish are extreme, but necessary for survival. ...
(Date:9/19/2014)... not evolve for the sake of fairness per se ... cooperation, so say Frans de Waal, PhD, and Sarah ... aversion (IA), which is defined as a negative reaction ... Science . , Their conclusion comes after the ... their hypothesis that it is the evolution of forestalling ...
(Date:9/19/2014)... SHELTON, Conn. , Sept. 19, 2014 Nxt-ID, Inc. ... a biometric authentication company focused on the growing m-commerce market, updates ... and world champion in the lightweight and light middleweight weight classes, ... Yesterday it was announced that Game of Thrones ... and Married with Children star Katey Sagal ...
Breaking Biology News(10 mins):Evolution of responses to (un)fairness 2Evolution of responses to (un)fairness 3NXT-ID's Vinny Paz Celebrity Ad Wocket Update: Katey Sagal and Ciaran Hinds Attached to His Upcoming Movie 2NXT-ID's Vinny Paz Celebrity Ad Wocket Update: Katey Sagal and Ciaran Hinds Attached to His Upcoming Movie 3
... is the latest American Chemical Society (ACS) News ... 36 major,peer-reviewed journals and Chemical & Engineering News. ... largest scientific society. Please,cite the individual journal, or ... information., , ARTICLE #1 FOR IMMEDIATE RELEASE , ...
... and its far reaching impacts will be discussed in New ... signs of climate change in their own countries -- Iceland ... can their countries serve as models for the rest of ... domestic and global climate change on Monday, Nov. 5 at ...
... Science and Technology (CAST) will make three presentations in ... the Annual Meetings of the American Society of Agronomy ... Science Society of America (SSSA). The presentations include the ... and ethanol production and a presentation outlining CASTs resources ...
Cached Biology News:American Chemical Society's Weekly PressPac -- Oct. 24, 2007 2American Chemical Society's Weekly PressPac -- Oct. 24, 2007 3American Chemical Society's Weekly PressPac -- Oct. 24, 2007 4American Chemical Society's Weekly PressPac -- Oct. 24, 2007 5American Chemical Society's Weekly PressPac -- Oct. 24, 2007 6American Chemical Society's Weekly PressPac -- Oct. 24, 2007 7American Chemical Society's Weekly PressPac -- Oct. 24, 2007 8Presidents of Iceland, Bangladesh to discuss global climate change in New Orleans 2CAST rolls out biofuel commentaries in New Orleans 2
(Date:9/22/2014)... , Sept. 22, 2014  WIRB-Copernicus Group ... ethical review services for clinical research, announced today ... (WIRB) has been reaccredited by the Association for ... which endeavors to improve safeguards for clinical research ... Donald A. Deieso , Ph.D., commented, "It is ...
(Date:9/22/2014)... METTLER TOLEDO is pleased to ... device CNS110 ScanTape™ . Replacing a traditional ... greater ease and accuracy for transport and logistics ... enhance productivity—an important benefit for load planning and ... profits. , Usable at any point in ...
(Date:9/22/2014)... BETHESDA, Md. , Sept. 22, 2014  Spherix Incorporated ... fostering and monetization of intellectual property, today announced that the ... patent to the Company in the month of September that ... The issued patent is: USRE45,121 , ... 2014 , Filing date: Dec 27, 2012 ...
(Date:9/21/2014)... time, scientists have discovered how to produce ultra-thin "diamond ... greater than that of today,s strongest nanotubes and polymers. ... led by John V. Badding, a professor of chemistry ... 21 September 2014 issue of the journal Nature ... our discovery is intriguing because the threads we formed ...
Breaking Biology Technology:Western IRB (WIRB) Awarded AAHRPP Reaccreditation 2ScanTape™ Handheld Dimensioner Increases Processing Volume 2Spherix Notified by United States Patent & Trademark Office of New Standard Essential Patent Issued to Spherix 2Spherix Notified by United States Patent & Trademark Office of New Standard Essential Patent Issued to Spherix 3Smallest possible diamonds form ultra-thin nanothreads 2Smallest possible diamonds form ultra-thin nanothreads 3Smallest possible diamonds form ultra-thin nanothreads 4
... Solution Enables Enhanced Productivity and Decreased Expenses, ... Inc., the global leader,in helping academic, healthcare ... procurement, today announced that BioMarin,Pharmaceutical Inc., a ... the SciQuest eprocurement platform to streamline and,enhance ...
... a white paper titled “Avanta AC™ Advanced ... Nanopowders” online. This white paper outlines the ... a nanometer scale, as well as the ... Advanced ceramic nanopowders are critical to a ...
... appeals to the Senate Judiciary Committee for a hearing regarding covert surveillance ... it were not for the fact that real people are being victimized ... ... Ohio (PRWEB) June 24, 2008 -- As the issue of torturing foreign ...
Cached Biology Technology:SciQuest Announces Newest Life Sciences Customer; BioMarin Pharmaceutical Drives Spending Effectiveness with Automated, Intuitive Procurement 2 SACHEM Launches New Products for High Purity Advanced Ceramic Powders : Avanta AC™ Advanced Ceramics Solutions Offer Unique Advantages over Inorganic Bases in the Manufacture of Advanced Ceramic Nanoparticles 2Covert Torture, Surveillance Jeopardizes the Freedom of American Citizens 2Covert Torture, Surveillance Jeopardizes the Freedom of American Citizens 3Covert Torture, Surveillance Jeopardizes the Freedom of American Citizens 4