Navigation Links
Scientists find hormone activity explains adolescent mood swings

The "raging hormones" of puberty are known to produce mood swings and stress for most teenagers, making it difficult to cope with this period of life. Until now, the specific causes of pubertal anxiety have not been identified, making it harder to understand and treat adolescent angst.

In the current edition of the journal Nature Neuroscience, researchers led by Sheryl S. Smith, PhD, professor of physiology and pharmacology at SUNY Downstate Medical Center, report findings demonstrating that a hormone normally released in response to stress, THP, actually reverses its effect at puberty, when it increases anxiety.

This hormone normally acts like a tranquilizer, acting at sites in the brain that "calm" brain activity. In the adult, this stress hormone helps the individual adapt to stress, with a calming effect produced half an hour after the event.

Specifically, the GABA-A receptor is the target for steroids, such as THP (or allopregnanolone), which reduce anxiety. GABA-A receptors calm activity in the brain. As such, they are the targets for most sedative, tranquilizing drugs.

One sub-type, GABA-A receptors containing the delta subunit, such as alpha4-beta2-delta, has the highest sensitivity to steroids. In order to study its role in puberty, the researchers used a mouse model that reliably predicts the human condition. In this rodent model, the alpha4-beta2-delta receptor normally has very low expression, but increases dramatically at the onset of puberty in the part of the brain that regulates emotion. Paradoxically, THP reduced the inhibition produced by these alpha4-beta2-delta GABA-A receptors, increasing brain activity to produce a state of increased anxiety. Stress also increased anxiety at puberty, due to the paradoxical effects of this hormone that is released by stress.

Dr. Smith and colleagues identified the site on human recombinant alpha4-beta2-delta GABA-A receptors that produced the anxiety response, a
'"/>

Source:SUNY Downstate Medical Center


Page: 1 2

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
(Date:9/30/2014)... face a suite of perilous threats in today,s ... and climate change, fragile coral ecosystems are disappearing ... trend, some species of corals surrounding the island ... protector in their tropical environment: coral guard-crabs. New ... Smithsonian Marine Station scientist Seabird McKeon and the ...
(Date:9/29/2014)... WASHINGTON, DC September 29, 2014 -- Plants ... ,commensal, bacteria help the pants extract nutrients and ... preventing pathogens from contaminating fruits and vegetables. Now, ... commensal bacteria inside of seeds; thus ensuring that ... researchers, from the University of Notre Dame, presented ...
(Date:9/29/2014)... University of Texas at Arlington research team says recently ... in their lab could open doors for homeland security ... published in the Oct. 1 issue of Optics ... his co-authors describe a new method to fabricate transparent ... oxygen until a transparent ceramic is formed. A ...
Breaking Biology News(10 mins):Smithsonian scientists discover coral's best defender against an army of sea stars 2Plants prepackage beneficial microbes in their seeds 2UT Arlington researchers develop new transparent nanoscintillators for radiation detection 2UT Arlington researchers develop new transparent nanoscintillators for radiation detection 3
... multiple sclerosis could be reversed by activating stem cells that ... has shown. Researchers from the Universities of Cambridge and ... known as myelin sheaths that protect nerve fibres ... showed how this mechanism can be exploited to make the ...
... For the first time, the barriers to breastfeeding are ... the release today of Healthy People 2020, ( http://www.hhs.gov/news/press/2010pres/12/20101202a.html ... has targeted the new 10-year goals for our nation,s ... "This is a major step forward for ...
... e-cigarettes), also called "electronic nicotine delivery systems," are ... is available on their health effects. In the ... malls in most states and on the Internet. ... this question, researchers at the University of California, ...
Cached Biology News:Study reveals new possibility of reversing damage caused by MS 2New public health goals tackle obstacles to breastfeeding success 2Electronic cigarettes are unsafe and pose health risks, UC Riverside study finds 2Electronic cigarettes are unsafe and pose health risks, UC Riverside study finds 3
(Date:9/30/2014)... iLab Solutions announced the results of its ... focuses on core facility operations, growth and utilization as ... , In its 4th year running, a number of ... year-over-year decrease in the percentage of revenue that comes ... the constraints of this trend. When asked, “What are ...
(Date:9/30/2014)... Lyme Research Alliance (LRA), the nation’s ... universities, today announced the awarding of seven grants worth ... cure for Lyme and other tick-borne diseases. , ... its history—over 20 grant proposals—a 100 percent increase from ... receive so many solid applications from talented scientists this ...
(Date:9/30/2014)... On September 11, Pharma IQ conducted an interview with ... session that he will lead on “Stem Cells” at the ... 2015 in London. In the interview posted online ... respond to several questions on the current state of technologies ... toxicity, and future trends in the use of stem cells ...
(Date:9/30/2014)... Back in the 1970’s, many companies calculated their office ... included space for circulation and file storage. “It was ... Nidea Corporate Real Estate / ITRA Global , a ... however, 250 square feet per employee became the norm. ... 175 to 225 square feet, and over the next few ...
Breaking Biology Technology:iLab Solutions Announces the Results of the 2014 Core Facility Benchmarking Study 2iLab Solutions Announces the Results of the 2014 Core Facility Benchmarking Study 3Lyme Research Alliance Awards Nearly $600,000 in New Grants 2Lyme Research Alliance Awards Nearly $600,000 in New Grants 3Lyme Research Alliance Awards Nearly $600,000 in New Grants 4Adult Stem Cell Technology Center, LLC Director James L. Sherley Discusses Stem Cell Toxicology 2Adult Stem Cell Technology Center, LLC Director James L. Sherley Discusses Stem Cell Toxicology 3Adult Stem Cell Technology Center, LLC Director James L. Sherley Discusses Stem Cell Toxicology 4ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 3
... Inc.,(OTC Bulletin Board: AVNA), announced today that its ... from SELEX GALILEO,totaling $629,000. SELEX GALILEO, a Finmeccanica ... organizations, is a leader in,surveillance, protection, tracking, targeting, ... the third order in 18 months from,SELEX GALILEO. ...
... CHAGRIN FALLS, Ohio, June 24 Knowledge Enterprises,Inc. ... the 4th Annual Orthopaedic Manufacturing & Technology Exposition ... 2007, with total attendance,nearing 1,000. "Based on the ... honored to report that OMTEC has secured a ...
... of Proven Clinical Trial Capability into the Frontage ... ... June 24 Frontage Laboratories,( http://www.frontagelab.com ) (Malvern and Exton, ... of bioanalytical, pre-clinical and,drug development services to the pharmaceutical industry, ...
Cached Biology Technology:Advance Nanotech's Owlstone Subsidiary Receives a $629,000 Order From Selex Galileo 2Advance Nanotech's Owlstone Subsidiary Receives a $629,000 Order From Selex Galileo 3Advance Nanotech's Owlstone Subsidiary Receives a $629,000 Order From Selex Galileo 4OMTEC 2008 Boasts Record Attendance and Secures Premier Position as Must-attend for Orthopaedic Companies 2Frontage Laboratories Completes Acquisition of Advanced Biomedical Research, Inc. (ABR) 2Frontage Laboratories Completes Acquisition of Advanced Biomedical Research, Inc. (ABR) 3Frontage Laboratories Completes Acquisition of Advanced Biomedical Research, Inc. (ABR) 4
... deuterium atoms at the 9, 10, 12, and ... an internal standard for the quantification of 13(S)-HODE ... by incubation of linoleic acid with plant and ... the adhesion of tumor cells to the endothelium ...
...
...
Immunogen: Peptide corresponding to amino acid residues from the N-terminal region of human thyroid hormone receptor, alpha1/alpha2-isotype. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: