Navigation Links
Scientists find a key to immune system's ability to remember

y the signatures of pathogens like measles virus and HIV, agents that hide inside cells.

Lck is important in helping "naive" T cells -- those cells that have never been exposed to a particular pathogen -- capture the receptor template of the invading agent and store it for future reference. Among the millions of naïve T cells, there are a few that are primed for active duty against an individual infectious agent. Following infection or vaccination, Lck initiates a biochemical chain of events that vastly increases the number of T cells that march off to combat the invader.

After the infection subsides, the number of T cells marshaled to fight that agent decreases dramatically. But a smaller subset, known as "memory" cells, retains the imprint of its previous encounter should the pathogen make a return appearance.

According to the study, while Lck primes naïve cells to fight a pathogen, it is not required by memory cells, which initiate the fast and furious response when that same pathogen comes calling again years later. Unlike naïve T cells, which are confined to the lymphatic system, memory T cells are found everywhere in the body, enabling them to sense and react more quickly when an infectious agent is reencountered.

"Now we know one of the reasons we get such a quick response and clearance (of the pathogen) with reinfection," Suresh explains. "If you increase the size of your army, you can clear your enemies faster. The memory T cells are greater in number and they are more potent."

The new insight could help refine therapeutic targets to treat autoimmune diseases and may inform new strategies for suppressing T cell response after transplantation. Now, transplant patients require life-long regimens of drugs to suppress immune response to the foreign cells in the donated organ.


'"/>

Source:University of Wisconsin-Madison


Page: 1 2

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Scientists find key immune system ability remember

(Date:7/11/2014)... division of the striatum is also involved in ... of substance P in the striatal marginal division ... his team, College of Biophotonics, South China Normal ... P receptor, neurokinin 1 was highly expressed in ... rats. Unilateral or bilateral injection of an antisense ...
(Date:7/11/2014)... 2014 Research and Markets has ... Market - Industry Analysis Size Share Growth Trends and ... http://photos.prnewswire.com/prnh/20130307/600769 The ... a need for high level security in both private ... such as username and passwords, tokens etc. are vulnerable ...
(Date:7/10/2014)... Santa Fe, Albuquerque, and other major cities in New ... with treated municipal wastewater rather than precious potable water ... than 40% of all golf courses receive treated effluent. ... , Additionally, golf courses and homeowners alike fertilize ... in fertilizer is nitrate. A New Mexico State University ...
Breaking Biology News(10 mins):International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019 2'Tailored' water -- the latest in lawn care 2
... landscape of our planet and the elemental forces that shape ... being led by The University of Nottingham. The Earth ... University,s School of Geography, is a two-year project funded with ... will focus on technology that can be used for a ...
... from the University of Pennsylvania have linked the ... dark contrasts of the natural world, demonstrating the likelihood ... adapted to best capture the world around us. ... darkness are more numerous and cluster closer together than ...
... -- The explosion of portable communication devices that we ... Bluetooth hands-free units, and wireless Internet networks -- has ... variety of integrated circuits that create, process and receive ... Continuing demand for higher performance over a ...
Cached Biology News:Keeping a watch on the world 2Keeping a watch on the world 3The world is full of darkness, reflected in the physiology of the human retina, Penn researchers say 2The world is full of darkness, reflected in the physiology of the human retina, Penn researchers say 3
(Date:7/10/2014)... 10, 2014 Robert Harman, DVM, Founder and ... is proud to announce the relaunch of his highly informative ... new series called “ What are Stem Cells ?” ... and straightforward foundation in the basics of stem cell therapy ... the right type of treatment when considering regenerative medicine. , ...
(Date:7/10/2014)... Senior supply chain management executives from over ... challenges of “Reducing Cost, Lead Time, & Defects in ... Describing the partnership of the Bio Supply Management Alliance ... ( SCMI) of the University of San Diego ... Kroc Institute of Peace and Justice in San Diego, ...
(Date:7/10/2014)...  Kainos Capital, a firm specializing in acquiring and ... has acquired the Slim-Fast brand from Unilever. Unilever will ... the transaction were not disclosed. Slim-Fast is ... markets ready-to-drink shakes, powders, bars and snacks to retail ... in the United Kingdom and ...
(Date:7/10/2014)...   Ceres, Inc . (Nasdaq: CERE ... financial results for the three months ended May 31, ... Ceres reported that the company and its customers ... season in Brazil, which concluded in June, despite dry ... areas for part of the growing season. Yields of ...
Breaking Biology Technology:Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4Kainos Capital Acquires Slim-Fast From Unilever 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9
... , COLUMBIA, Md., Aug. 20 Martek Biosciences Corporation ... into a multi-year, sole-source supply agreement with Milk Powder Solutions, based ... as Milk Powder Solutions, exclusive supplier for all of its ARA ... Gold Cow brand name. , , "This new ...
... BEIJING, Aug. 20 /PRNewswire-Asia-FirstCall/ -- China Medical Technologies,Inc. ... China-based medical device,company that develops, manufactures and markets advanced ... unaudited financial results,for the fourth fiscal quarter ("4Q FY2008") ... first fiscal quarter ("1Q FY2009") ended June 30, 2009,before ...
... , BELLE MEAD, N.J., Aug. 19 ... Jersey will streamline and improve the quality of care for patients ... i ng.net ), a leader in healthcare technology. ... to oversee all aspects of practice management and electronic health record ...
Cached Biology Technology:Martek Signs Sole-Source Supply Agreement with Milk Powder Solutions 2Martek Signs Sole-Source Supply Agreement with Milk Powder Solutions 3China Medical Technologies to Announce Unaudited Financial Results for the Fourth Fiscal Quarter and Fiscal Year ended March 31, 2009 and the First Fiscal Quarter ended June 30, 2009 on September 1, 2009 2New Jersey Surgery Centers Pick Health Informatics Consulting to Implement Patient Electronic Health Record Systems 2