Navigation Links
Scientists elucidate the kinome of key model organism

The journal PLoS Genetics has published the findings of a team of scientists at the nonprofit Boston Biomedical Research Institute that provides a whole genome analysis of the protein kinases from a scientifically valuable model organism known as Dictyostelium.

Led by Dr. Janet Smith, this study offers important insights into the evolution of kinases, which are enzymes involved in cell communication pathways. Approximately 2.5% of human genes code for protein kinases, and mutations in many of these genes are at the root of a range of human diseases. Dictyostelium is a widely used model organism for scientific study, as it is remarkably similar to mammalian cells, and it is amenable to a range of laboratory techniques.

To solve the kinome of Dictyostelium, Dr. Smith and her colleagues at Boston Biomedical utilized the power of bioinformatics, a cutting edge scientific technique which employs databases and computer algorithms to allow researchers to gain information and compile data about genes and kinases in a fast and efficient way, which can be very useful for drug discovery and development.

According to Dr. Smith, Dictyostelium provides a simple model in which to study conserved cellular processes, and illuminates a period in the evolutionary history of the metazoa after the divergence of the plants but before that of the fungi. "Our findings document the impressive evolutionary creativity of the Dictyostelium kinome- a large portion of the kinases are unique to Dictyostelium, and are probably involved in unique aspects of this organism's biology," said Dr. Smith.

But conservation is also a major theme. By comparing the Dictyostelium kinome with those of other organisms, the authors find 46 types of kinases that appear to be conserved in all organisms, and are likely to be involved in fundamental cellular processes. "We believe this study will be very useful to researchers who are studying cell communication pathways in other
'"/>

Source:Public Library of Science


Page: 1 2

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Scientists elucidate the kinome key model organism

(Date:5/8/2015)... Calif. , May 8, 2015 Synaptics Inc. ... solutions, today announced that members of the executive management team ... Morgan 43rd Annual Technology, Media and Telecom Conference Date: ... Hotel in Boston, MA ... 27, 2015 Time: 2:45pm ET Location: The New York Palace ...
(Date:5/6/2015)... TEL AVIV, Israel , May 6, 2015 /PRNewswire/ ... the world,s most established helmet producer, announced today that ... LifeBEAM Smart Helmet, the world,s first bio-sensing cycling helmet ... will be released in two new colors in order ... demand for the product. In addition, LifeBEAM and Lazer ...
(Date:4/27/2015)... 27, 2015  For more than four decades, AUVSI,s ... been the premier worldwide event for the unmanned land, ... must-attend event for any local, national, or trade news ... commercial markets and current applications of unmanned technologies. The ... projected $48 billion industry, and how it will soon ...
Breaking Biology News(10 mins):Synaptics to Present at Upcoming Investor Conferences 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5
... TorontoResearchers at the University of Toronto, The Hospital ... University of British Columbia have identified a new treatment ... and an estimated 10% of common colds. The virus, ... most common reason for hospitalization of infants and children ...
... led by St. Jude Children,s Research Hospital scientists has ... childhood eye tumor retinoblastoma. Their work also settles a ... as scrambled as the developmental pathways at work in ... particular type of cell, researchers showed that retinoblastoma is ...
... A recent study suggests that parasites in fish, including ... impacts on fish health than has been assumed, and could ... land use changes cause salmon mortality. It,s not just ... research found, but their numbers that can build up over ...
Cached Biology News:Researchers map pathway of infection for a common, potentially life-threatening respiratory virus 2Childhood eye tumor made up of hybrid cells with jumbled development 2Childhood eye tumor made up of hybrid cells with jumbled development 3Parasite loads an underlying cause of salmon mortality, linked to land use changes 2
(Date:5/29/2015)... CA (PRWEB) May 29, 2015 ... addressing multi-drug-resistant organisms (MDROs), announced that initial feasibility ... same-shift bacterial detection and susceptibility testing from positive ... on May 31, 2015 in New Orleans, ... class of molecular diagnostics that can quickly detect ...
(Date:5/29/2015)... Market Publishers Ltd and Shanghai ... partnership agreement for quality market research promotion on ... sell research reports worked out by Chem-Report. , ... upon the agreement: “Chem-Report is a Chinese company ... chemical markets on global and country levels. The ...
(Date:5/29/2015)... , May 29, 2015  Caris Life Sciences® ... studies in which researchers utilized Caris Molecular Intelligence®, ... identify potential therapeutic targets in patients with colorectal ... the programmed cell death protein 1 (PD-1) and ... 1 at the 2015 American Society of Clinical ...
(Date:5/29/2015)... and RESEARCH TRIANGLE PARK, N.C. , ... UTHR ) announced today that Roger Jeffs , Ph.D., ... an overview and update on the company,s business at the ... City . The presentation and the immediately ... 2015, at 11:00 AM Eastern Time, and can be accessed ...
Breaking Biology Technology:Data Highlighting GeneWEAVE’s Smarticles™ Technology to be Presented at the 115th General Meeting of the American Society for Microbiology (asm2015) 2Data Highlighting GeneWEAVE’s Smarticles™ Technology to be Presented at the 115th General Meeting of the American Society for Microbiology (asm2015) 3Market Publishers Ltd and Chem-Report Sign Partnership Agreement 2Market Publishers Ltd and Chem-Report Sign Partnership Agreement 3Multi-Platform Molecular Profiling from Caris Life Sciences Identifies Clinically Actionable Targets for Novel Immunotherapy Drugs 2Multi-Platform Molecular Profiling from Caris Life Sciences Identifies Clinically Actionable Targets for Novel Immunotherapy Drugs 3Multi-Platform Molecular Profiling from Caris Life Sciences Identifies Clinically Actionable Targets for Novel Immunotherapy Drugs 4
... Oct. 8 Inverness Medical,Innovations (Amex: IMA ) ... Agreement with Panbio Ltd, an Australian company traded on,the ... will acquire all of the issued shares in Panbio ... values the issued share capital of,Panbio at approximately AUD ...
... Outstanding Companies, Individuals, and Scientific Achievements are Honored ... at the 20th Biotech Meeting, Laguna Niguel, ... Meeting at Laguna Niguel, a biotech CEO-only conference hosted by,Burrill ... the,Biotech Hall of Fame were announced at an Awards Dinner ...
... 8 Clinsys Clinical,Research, Inc., a therapeutically ... of its corporate headquarters to accommodate,the company,s ... The new,larger facility is located in Bedminster, ... with our recent expansion of operations,in Raleigh, ...
Cached Biology Technology:Inverness Medical Innovations Agrees to Acquire Panbio Ltd. 2Biotech Hall of Fame Inductees Announced 2Biotech Hall of Fame Inductees Announced 3Biotech Hall of Fame Inductees Announced 4Biotech Hall of Fame Inductees Announced 5Biotech Hall of Fame Inductees Announced 6Clinsys Clinical Research, Inc. Announces Relocation of Corporate Headquarters 2
Performance, mycoplasma, virus, and endotoxin tested...
... 10X BlueJuice Gel Loading ... easy loading and tracking ... agarose or native polyacrylamide ... features higher density sucrose ...
... is the most effective ... PCR products. TOPO TA ... TOPO vectors are supplied ... topoisomerase I. This enables ...
ready-to-use solution...
Biology Products: