Navigation Links
Scientists discover why cornea is transparent and free of blood vessels, allowing vision

ts.

Using corneal tissue from mice, the team did the following.

They conducted chemical analyses that demonstrated that VEFGR-3 and the gene that expressed it were indeed present on the corneal epithelium. Next, in two separate experiments, they compared corneas with and without epithelial layers that were injured. They found that only the corneas without epithelial layers developed blood vessels, implicating the role of the epithelium in suppressing blood vessel growth To further prove their theory, they added a VEGFR-3 substitute to corneas stripped of their epithelial layers and found that vessel growth continued to be suppressed, replacing the normal anti-angiogenic role of the epithelium. Finally they exposed intact corneas to an agent that blocked VEGFR-3 and found that blood vessels began to grow, formally demonstrating that the corneal epithelium is key to suppression of blood vessels and that the key mechanism is expression of VEGFR-3.

"The results from this series of tests, confirmed our belief that the presence of VEGFR-3 is the major factor in preventing blood vessel formation in the cornea," says Dana, who says that the discovery will have a far reaching impact on the development of new therapies for eye and other diseases.

"Drugs designed to manipulate the levels of this protein could heal corneas that have undergone severe trauma or help shrink tumors fed by rapidly growing abnormal blood vessels," he says. "In fact, the next step in our work is exactly this."


'"/>

Source:Schepens Eye Research Institute


Page: 1 2 3

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding

Post Your Comments:
(Date:11/19/2009)... MADISON This week, scientists are revealing the ...hree cereal crops. Corn, or maize, has one of the ...University of Wisconsin-Madison genomicist David S...he article in the journal Science . , "The maiz... and dead-ends that have troubled would-be sequenc...
(Date:11/19/2009)... In a massive survey of genetic diversity in maize...d States, have developed a gene map that should pa...that is a major source of food, fuel, animal feed ...cial type of gene map known as a haplotype map, ch...e genome of 27 inbred lines of maize. The research...
(Date:11/19/2009)... A team led by Penn State,s Ross Hardison, T. Ming...gy, has taken a large step toward unraveling how r...products during development and growth. Working wi... Gerd Blobel at Children,s Hospital of Philadelphi...s of producing red blood cells (erythrocytes). The...
Breaking Biology News(10 mins):Sweet corn story begins in UW-Madison lab 2Sweet corn story begins in UW-Madison lab 3New research into the mechanisms of gene regulation 2New research into the mechanisms of gene regulation 3New research into the mechanisms of gene regulation 4New research into the mechanisms of gene regulation 5Fight to Preserve Flexible Spending Accounts Moves to the House of Representatives 59453 1Fight to Preserve Flexible Spending Accounts Moves to the House of Representatives 59453 2Fight to Preserve Flexible Spending Accounts Moves to the House of Representatives 59453 3Leading Southern California Physicians Report Patient Fears About Complexities of Flu Season 59450 1Leading Southern California Physicians Report Patient Fears About Complexities of Flu Season 59450 2VirtualScopics to Present at the 8th Annual Bio Investor Forum 5470 1VirtualScopics to Present at the 8th Annual Bio Investor Forum 5470 2
... Washington University in St. Louis has shown that...larger sexual organs, and actually choose them for...ge-sized sex organ, called a gonopodium. These fis...or-laden environment because they have a faster bu...o lose out because the size of their organ slows t...
... skeleton of a small crocodile relative excavated ...zona throws a wrench into theories of how and wher...ago at the end of the Triassic Period. , The anim...nown only from their teeth, was thought to be an a...s like Stegosaurus and Triceratops, which roamed t...
... plasma protein found in blood, can be fused with ...ony-stimulating factor (G-CSF) to create a new ora...y through the gastrointestinal (GI) tract and then...d by the body, according to research from the Univ..., This technology may allow for oral administratio...
Other Biology News:Certain fish have a special mating preference 2Certain fish have a special mating preference 3Certain fish have a special mating preference 4Agilent Technologies introduces high-capacity human protein removal system for proteomics research 2Agilent Technologies introduces high-capacity human protein removal system for proteomics research 3Agilent Technologies introduces high-capacity human protein removal system for proteomics research 4Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs 2Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs 3
(Date:11/19/2009)...Md., Nov. 19 Spherix Inc...hnology for diabetes therapy, and a provider of te..., supplement, biotechnology and pharmaceutical com...eported $6.3 million registered direct placement t...ts common stock and warrants to purchase up to 1,1...
(Date:11/19/2009)...ALTHAM, Mass., Nov. 19 Arlington M... that the leading driver of antibiotic selection i... activity against gram-positive and gram-negative ...n cause nosocomial pneumonia, surveyed European ph...s that provide appropriate coverage against common...
(Date:11/19/2009)...IK surgeons and recognized refractive and cataract...made brought their fellow surgeons up-to-date on t...y, cataract surgery, and ophthalmology in general ...halmology (AAO) annual meeting in San Francisco, C...er, Dr. David Huang, MD, Dr. Randy Epstein, Dr. Wi...
(Date:11/19/2009)...a, November 19 AFFiRiS AG will foc...candidate at an unexpectedly early,stage of develo...ter into,Phase II clinical trial early in 2010. Th... completion of two Phase I trials with the candida...sion on the first interim,analysis of the secondar...
Breaking Biology Technology:Spherix Announces the Closing of $6.3 Million Registered Direct Offering 2Spherix Announces the Closing of $6.3 Million Registered Direct Offering 3Broad-Spectrum Antibacterial Activity is the Most Important Driver of Antibiotic Selection for Nosocomial Pneumonia In Europe 2Broad-Spectrum Antibacterial Activity is the Most Important Driver of Antibiotic Selection for Nosocomial Pneumonia In Europe 3Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 2Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 3Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 4Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 5Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 6Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 7Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 8Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 9AFFiRiS AG: Interim Analysis of Clinical Phase I Data Triggered Decision to Move Alzheimer's Vaccine Candidate AD02 into Clinical Phase II Testing 2AFFiRiS AG: Interim Analysis of Clinical Phase I Data Triggered Decision to Move Alzheimer's Vaccine Candidate AD02 into Clinical Phase II Testing 3
...E -- Mayor Tom Barrett and Milwaukee officials on... Wireless Initiative to provide a citywide wireles...aukee Wireless Initiative positions Milwaukee to b...ca, built at no cost to the city and taxpayers, ac...ve constitutes a multi-million dollar private inve...
... Wis. - Trying to find a vaccine for AIDS is tric...in five different places on a sprawling university...niversity of Wisconsin-Madison,s new AIDS Vaccine ...cts for eventual success seemed all the more possi...que that may hold greater promise to prevent AIDS ...
...d Drug Administration (FDA) approval or authorizat...reatment,s success. But coverage and reimbursement...e" is whether there will be payment by an insurer ...nt there will be if there is coverage. , ,Unlike t...r evaluation of new products and, depending on the...
Other Biology Technology:Milwaukee announces citywide wireless initiative 2New digs for UW AIDS researchers 2On track with the FDA -- But what about your coverage and reimbursement strategy? 2On track with the FDA -- But what about your coverage and reimbursement strategy? 3On track with the FDA -- But what about your coverage and reimbursement strategy? 4
DNP-X acid, SE -- [6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester] from AnaSpec
Goat Anti-CLIM-2 (T-16) Polyclonal Antibody, Unconjugated from Santa Cruz Biotechnology, Inc.
Goat Anti-Human Dysadherin 2 Polyclonal Antibody, Unconjugated from Santa Cruz Biotechnology, Inc.
Anti-MPM-2, phospho-Ser / Thr-Pro (Mitotic protein monoclonal #2) Antibody, Agarose Conjugated from Upstate
Biology Products: