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Scientists discover that three molecules may be developed into new Alzheimer's drugs

of the pocket, and a third appears to bind completely outside the pocket. The scientists are most interested in the second and third compounds.

"This is the first demonstration that we can find small molecules that can more specifically affect the phosphorylation of tau by CDK5," said Kosik.

In terms of future directions, Kosik said, "There is lots to do here, lab testing, testing in animals, etc. But we have made an important step forward toward developing treatments for this disease."

He noted that this work is of a type usually performed by pharmaceutical companies, but in this case was completed in an academic environment.


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Source:University of California - Santa Barbara


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