Navigation Links
Scientists discover gene that controls speed of tuberculosis development

Scientists at the MUHC have discovered a gene that controls the speed at which patients develop tuberculosis--the first time such a gene has been discovered for this disease. The new study published in the Proceedings of the National Academy of Science (PNAS) this week provides a new view of the mechanisms underlying the development of tuberculosis and may contribute to public health efforts aimed at containing the disease.

"About one-third of the world's population is infected by Mycobacterium tuberculosis--the bacteria responsible for tuberculosis," says Dr. Erwin Schurr, a molecular geneticist at the Centre for the Study of Host Resistance at the MUHC, and the study's principal investigator. "Of the estimated two billion people infected, only 5%-10% actually develop tuberculosis disease in their lifetime--the other 90%-95% appear to be able to contain the infection in a dormant state, so that they do not become ill." Dr. Schurr has spent the past 5 years researching why and how this happens.

The new research focused on NRAMP1--a gene already known to be involved in many other illnesses, including diseases as diverse as leprosy and rheumatoid arthritis. "We discovered that variants (alleles) of the NRAMP1 gene control the speed at which tuberculosis develops, rather than whether or not it will develop at all," says Dr. Schurr. "This is the first time a gene has been shown to control the time frame between initial infection and the disease." Certain factors are already known to increase the speed at which people develop tuberculosis. "HIV and tuberculosis are synergistic partners in crime for example," says Dr. Schurr. "They appear to accelerate disease progression when they occur together."

"Understanding the basic pathways of pathogenesis offers new targets and policies for disease prevention," notes Dr. Emil Skamene, Scientific Director of the Research Institute of the MUHC. "Academic hospitals such as the MUHC combine scientific research, technology and clinic expertise, enabling scientific breakthroughs to be developed into treatments and cures that directly benefit patients."


Source:McGill University

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:

(Date:10/12/2015)... Research and Markets ( ) ... Recognition Market by Component (Hardware & Software), Product ... Industry (Travel & Immigration, Military & Defense, & ... report to their offering. ... Market worth 3627.90 Million USD by 2020 ...
(Date:10/8/2015)... LAKE CITY , 8. Oktober 2015 ... TRCK), ein global tätiges Unternehmen des Bereiches ... einem Vertrag mit der Gefängnisbehörde Virginias (Department ... dessen Rahmen elektronische Überwachungsdienste für alle Strafen ... Derek Cassell , Präsident für den ...
(Date:10/7/2015)... NXTD ) ("NXT-ID" or the ... mobile commerce market and creator of the Wocket® smart ... long- term executive at American Express has been appointed ... ) ("NXT-ID" or the "Company"), a biometric authentication company ... of the Wocket® smart wallet announces Mr. Stanley ...
Breaking Biology News(10 mins):
(Date:10/12/2015)... cell surface marker detection market ... to a new report by Grand View Research, Inc. This ... of oncology diseases and other cell-associated disorders. --> ... USD 6.49 billion by 2022, according to a new report ... be attributed to rise in incidence of oncology diseases and ...
(Date:10/12/2015)... 2015  Patara Pharma, a clinical-stage biotechnology company ... and conditions, today announced the closing of a ... with the close of its sale of preferred ... Security Agreement with Silicon Valley Bank whereby the ... will use the funds from the financing to ...
(Date:10/12/2015)... 12, 2015 VolitionRx Limited (NYSE MKT: ... study of its NuQ ® blood-based test for early ... of Clinical Epigenetics , the official journal of the ... with Lund University, Sweden ... PhD, Professor of Surgery and Vice-Dean, Faculty of Medicine. ...
(Date:10/12/2015)... ... October 12, 2015 , ... LifeTrak , a leader in ... Zoom, the world’s first amphibious fitness tracker that seeks to meet the needs of ... accurate heart rate monitoring both in water and on land, making it ...
Breaking Biology Technology: