Navigation Links
Scientists discover a new disease-causing bacterium in an immune-compromised patient

Researchers discovered a new bacterium in an immune-compromised patient, according to a study recently published in PLoS Pathogens. The bacterium belongs to the family Acetobacteraceae and includes bacteria common in the environment, some of which are used in industry, such as vinegar-making. "This is the first reported case of invasive human disease caused by any of the Acetobacteraceae," according to the article.

The new bacterium was identified in a patient with chronic granulomatous disease (CGD), a rare genetic disorder that impairs the immune system. In the patient, the bacterium caused fever, lymph node inflammation, and weight loss, but not death.

The journal also published an editorial entitled, "Extending the Spectrum of Human Pathogens," which comments on the significance of the discovery.

Usually, our immune systems fight off most bacteria and fungi with everyday ease, thwarting infection. But patients with CGD cannot control attacks by certain bacteria and fungi. The disorder prevents immune cells called neutrophils from functioning properly, and recurrent --and potentially life-threatening-- infections result.

The team isolated the new bacterium from the patient's swollen lymph nodes and demonstrated its pathogenesis. "Our first concern was to determine whether this organism was truly associated with his clinical syndrome," the team wrote.

Despite ineffective neutrophil immune cells, the patient's immune system still tagged the bacterium as an invader. Researchers also exposed CGD mice to the bacterium, recreating the appearance of the patient's infection. Researchers were then able to retrieve the bacteria from the mice's spleens, which are disease-fighting organs. These factors all support the pathogenic nature of the bacterium.

Because the bacterium does not cause death, it may be provide useful comparison with more menacing bacteria and fungi in CGD patients. "Given its appare nt low virulence, further investigation of this organism may shed light on the mechanisms of microbial killing in CGD. Comparing the genome of this organism to other 13 available genomes of CGD pathogens may provide clues to virulence properties that they share in common," according to the article.


'"/>

Source:Public Library of Science


Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/20/2016)... , Jan. 20, 2016   MedNet Solutions ... the entire spectrum of clinical research, is pleased to ... MedNet,s significant achievements are the result of the company,s ... iMedNet eClinical , it,s comprehensive, easy-to-use and ... --> Key MedNet growth achievements in ...
(Date:1/15/2016)... , Jan. 15, 2016 Recent publicized ... small to find new ways to ensure data security ... iOS and Android that ties ... biometrics, transforming it into a hardware authorization token. Customer ... swipe their fingerprint on their KodeKey enabled device to ...
(Date:1/11/2016)... Synaptics Incorporated (NASDAQ: SYNA ), the ... its ClearPad ® TouchView ™ 4300 touch ... categories in the 8 th Annual Mobile Excellence ... The Synaptics ® TDDI solution enables faster time-to-market, ... devices, brighter displays and borderless designs. ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... La Jolla CA (PRWEB) , ... February 10, 2016 , ... ... of new agents for the treatment of Alzheimer’s disease, announced today it has been ... to February 18th at the Breakers in Palm Beach, Florida. The purpose of ...
(Date:2/9/2016)... ... February 08, 2016 , ... ... services, announced today the launch of its revamped and improved website. In an ... service solutions, the redesigned website will better communicate how the company designs and ...
(Date:2/9/2016)... Lawrenceville, NJ (PRWEB) , ... February 09, 2016 ... ... Diane Dorman, former Vice President for Public Policy for the National Organization for ... and patient advocacy groups to ensure their voices are heard throughout the drug ...
(Date:2/9/2016)... 2016 BERG, a biopharmaceutical company uncovering ... has announced the appointment of Jason Haddock ... Officer. Haddock brings to BERG over 20 years ... in senior financial functions at pharmaceutical companies, as ... management. Niven R. Narain , ...
Breaking Biology Technology: