Navigation Links
Scientists discover a new disease-causing bacterium in an immune-compromised patient

Researchers discovered a new bacterium in an immune-compromised patient, according to a study recently published in PLoS Pathogens. The bacterium belongs to the family Acetobacteraceae and includes bacteria common in the environment, some of which are used in industry, such as vinegar-making. "This is the first reported case of invasive human disease caused by any of the Acetobacteraceae," according to the article.

The new bacterium was identified in a patient with chronic granulomatous disease (CGD), a rare genetic disorder that impairs the immune system. In the patient, the bacterium caused fever, lymph node inflammation, and weight loss, but not death.

The journal also published an editorial entitled, "Extending the Spectrum of Human Pathogens," which comments on the significance of the discovery.

Usually, our immune systems fight off most bacteria and fungi with everyday ease, thwarting infection. But patients with CGD cannot control attacks by certain bacteria and fungi. The disorder prevents immune cells called neutrophils from functioning properly, and recurrent --and potentially life-threatening-- infections result.

The team isolated the new bacterium from the patient's swollen lymph nodes and demonstrated its pathogenesis. "Our first concern was to determine whether this organism was truly associated with his clinical syndrome," the team wrote.

Despite ineffective neutrophil immune cells, the patient's immune system still tagged the bacterium as an invader. Researchers also exposed CGD mice to the bacterium, recreating the appearance of the patient's infection. Researchers were then able to retrieve the bacteria from the mice's spleens, which are disease-fighting organs. These factors all support the pathogenic nature of the bacterium.

Because the bacterium does not cause death, it may be provide useful comparison with more menacing bacteria and fungi in CGD patients. "Given its appare
'"/>

Source:Public Library of Science


Page: 1 2

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
(Date:6/17/2015)... Germany , June 17, 2015 ... Standard: QIA) today launched new Investigator ® STR assay ... the United States . The new genetic ... key genomic markers (short tandem repeats or STRs) for DNA ... evaluate the quality of DNA in each sample, a novel ...
(Date:6/17/2015)... Fla. , June 17, 2015  Crossmatch™, ... today announced that its U.are.U ® 4500 ... Togo,s Eateries, Inc., a ... sandwich chain, to increase security, improve accountability and ... readers enable instant, non-repudiable identity confirmation for employee ...
(Date:6/16/2015)... , June 16, 2015  With the increasing number ... remains a top concern. The recent compromise of ... need for strong authentication within government agencies. ... biometric one-time password (OTP) authenticator, has been submitted for ... 140-2 Level 3 validation for tamper proofing. ...
Breaking Biology News(10 mins):QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 4QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 5Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 2Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 3Government Ready Biometric Security Approaching as HYPR Corp. Files FIPS 140-2 Level 3 Validation for Its Proprietary Biometric Token 2Government Ready Biometric Security Approaching as HYPR Corp. Files FIPS 140-2 Level 3 Validation for Its Proprietary Biometric Token 3
... 2011, Cleveland: Researchers have identified a genetic mutation found ... a fatal developmental disease in fetuses and infants, according ... of Science . The genetic mutation is ... causing microcephalic osteodysplastic primoridal dwarfism type 1 (MOPD1), a ...
... using biofuels for gasoline. About a quarter of their ... carbon dioxide emissions that otherwise would be emitted from ... of Global Ecology have found that sugarcane has a ... occupied by other Brazilian crops cools the local climate. ...
... annual Nutrition & The Eye conference, April 16-17, hosted by ... St. Louis, says molecular medicine is beginning to provide hope ... been exhausted. "These nutritional molecules have begun to be ... and some human studies", Dr Richer reported. Dr. Richer ...
Cached Biology News:Genetic mutation linked to lethal disease 2Sugarcane cools climate 2Low-cost molecular medicine should be included in modern eye physicians' tool kit 2
(Date:7/6/2015)... 6, 2015  Approximately 1% of the population inherits ... chromosomes. These individuals are three times more likely to ... one of the nation,s leading medical journals by researchers ... Photo - http://photos.prnewswire.com/prnh/20150706/230685 ... causes roseola (also known as "sixth disease") and occasional ...
(Date:7/6/2015)... ... 06, 2015 , ... Discovery of new biomarkers for patient ... of the global molecular diagnostics market. BCC Research reveals in its new report ... diagnostic tests will increase demand for inexpensive and accurate tests for genetic compatibility ...
(Date:7/6/2015)... July 6, 2015  Viveve Medical, Inc. ("Viveve") (OTCQB: VIVMF), a ... Scheller , Viveve,s Chief Executive Officer, and Scott Durbin ... on July 9, 2015. , , , DATE:    ... , , , TIME:     , , , 12:15 ... , , http://tinyurl.com/viveve   , ...
(Date:7/6/2015)... , July 6, 2015 ImmunoCellular Therapeutics, ... of an agreement with Novella Clinical (Novella), ... in patients with newly diagnosed glioblastoma. Novella is a ... services to small to mid-sized oncology companies. The ICT-107 ... in the US, Europe and ...
Breaking Biology Technology:Inherited Herpes Virus Increases the Risk of Angina Reports HHV-6 Foundation 2Inherited Herpes Virus Increases the Risk of Angina Reports HHV-6 Foundation 3Demand for Personalized Medicine, Innovative Molecular Diagnostic Tests Spurring Big Growth, According to BCC Research 2Demand for Personalized Medicine, Innovative Molecular Diagnostic Tests Spurring Big Growth, According to BCC Research 3Viveve to Webcast Live at VirtualInvestorConferences.com 2Viveve to Webcast Live at VirtualInvestorConferences.com 3ImmunoCellular Therapeutics Establishes Agreement with Novella Clinical to Conduct ICT-107 Phase 3 Registration Trial in Glioblastoma 2
... SUMMIT and TOKYO, February 4 Bluegiga,announced today ... with,Bluetooth Health Device Profile (HDP). The Health Device ... the Bluegiga,module, significantly simplifying and reducing the need ... health or medical device. , ...
... model isn,t your father,s nanocar. It runs cool. , The ... versions of their creation have the ability to roll at ... be years away, the breakthrough suggests they,ll be easier to ... which had to be heated to 200 degrees Celsius before ...
... high-performing cold weather biodieselSAN FRANCISCO, Feb. 3 /PRNewswire/ ... producer of small-to-medium scale biodiesel production equipment and ... the release of "Greenline Tea FASTRACK ", ... of materials with a new equipment and process ...
Cached Biology Technology:Bluegiga Provides Health Device Profile for its Bluetooth OEM Modules 2Rice rolls out new nanocars 2Rice rolls out new nanocars 3New Greenline Tea FASTRACK Solves Cold-Flow Issues 2
... ester can be used to ... The covalently bound acridinium NHS ... the presence of hydrogen peroxide. ... be used as a detection ...
... up to 6 strain chambers with precise uniaxial ... design ensures that cells grow over long periods ... This unit allows you to control the frequency ... unique strain settings. The instrument fits in a ...
... a novel procedure for the uniform amplification ... genome DNA from small samples. This method ... and highly reproducible amplification and labeling procedure ... REPLI-g Mini Kit module (QIAGEN) and a ...
... using PULSin may be superior to transfection ... traditional transfection, with PULSin you can study ... time course of proteins in cells. Likewise, ... information than traditional RNA interference experiments. ...
Biology Products: