Navigation Links
Scientists discover a new disease-causing bacterium in an immune-compromised patient

Researchers discovered a new bacterium in an immune-compromised patient, according to a study recently published in PLoS Pathogens. The bacterium belongs to the family Acetobacteraceae and includes bacteria common in the environment, some of which are used in industry, such as vinegar-making. "This is the first reported case of invasive human disease caused by any of the Acetobacteraceae," according to the article.

The new bacterium was identified in a patient with chronic granulomatous disease (CGD), a rare genetic disorder that impairs the immune system. In the patient, the bacterium caused fever, lymph node inflammation, and weight loss, but not death.

The journal also published an editorial entitled, "Extending the Spectrum of Human Pathogens," which comments on the significance of the discovery.

Usually, our immune systems fight off most bacteria and fungi with everyday ease, thwarting infection. But patients with CGD cannot control attacks by certain bacteria and fungi. The disorder prevents immune cells called neutrophils from functioning properly, and recurrent --and potentially life-threatening-- infections result.

The team isolated the new bacterium from the patient's swollen lymph nodes and demonstrated its pathogenesis. "Our first concern was to determine whether this organism was truly associated with his clinical syndrome," the team wrote.

Despite ineffective neutrophil immune cells, the patient's immune system still tagged the bacterium as an invader. Researchers also exposed CGD mice to the bacterium, recreating the appearance of the patient's infection. Researchers were then able to retrieve the bacteria from the mice's spleens, which are disease-fighting organs. These factors all support the pathogenic nature of the bacterium.

Because the bacterium does not cause death, it may be provide useful comparison with more menacing bacteria and fungi in CGD patients. "Given its appare nt low virulence, further investigation of this organism may shed light on the mechanisms of microbial killing in CGD. Comparing the genome of this organism to other 13 available genomes of CGD pathogens may provide clues to virulence properties that they share in common," according to the article.


'"/>

Source:Public Library of Science


Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/2/2016)... YORK , Feb. 2, 2016 ... of that Rising Market Are you interested ... analysis forecasts revenues for checkpoint inhibitors. Visiongain,s report ... market, submarket, product and national level. Avoid ... discover what progress, opportunities and revenues those emerging ...
(Date:2/1/2016)... Feb. 1, 2016  Today, the first day of ... plans to develop a first of its kind workplace ... IBM Watson. In the first application of ... IBM ), and Welltok will create a new ... with cognitive analytics, delivered on Welltok,s health optimization platform. ...
(Date:1/25/2016)... , Jan. 25, 2016  Glencoe Software, the ... pharma and publication industries, will provide the data management ... Centre (NPSC). ... Phenotypic analysis measures ... whole organisms, allowing comparisons between states such as health ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... ... February 10, 2016 , ... Curoverse ... Azure. On Azure, Arvados provides capabilities for managing and processing genomic and health ... Azure from major institutions collecting and analyzing genomic data,” said Adam Berrey chief ...
(Date:2/10/2016)... ... ... Cenna Bioscience Inc., an emerging biopharmaceutical company focused on the discovery and ... been selected to present at the Cavendish Global Health Impact Forum taking place February ... of the Forum is to help family offices and foundations develop and implement their ...
(Date:2/9/2016)... ... ... With a presidential election in November and the future of U.S. healthcare ... 500 top healthcare leaders for a night and day of debates and discussions about ... of the University of Pennsylvania’s Wharton School, will be held February 18 – 19, ...
(Date:2/9/2016)... ... 2016 , ... Date and time: March 1, 2016, 5:30 ... Biotechnology Center of Bucks County, 3805 Old Easton Road, Doylestown, PA 18902. , ... an open house for participants to learn about a new Master of Biomedical ...
Breaking Biology Technology: