Navigation Links
Scientists directly view immune cells interacting to avert autoimmunity

his study to be consistent in humans.

The UCSF team has already developed a regulatory T cell-based therapy that can prevent and even reverse the course of autoimmune diabetes in mouse models, and this study begins to analyze how such protection occurs in vivo, she explained.

"By understanding the interplay between pathogenic cells and protective cells, we hope to be able to refine the therapy to enhance its efficacy."

The microscopy technique is a vital new tool, Tang said. "The function of the immune system involves multiple cell types interacting dynamically in three dimensions, which is very difficult to analyze in vivo -- and nearly impossible to authentically reproduce in vitro."

The team of immunologists and diabetes researchers used the new microscope to show that when Treg cells are absent, the potentially destructive autoreactive T cells, known as T helper cells, swarm around the dendritic cells where they are primed to attack the body's own tissue -- the cause of type 1 diabetes, arthritis and other autoimmune diseases.

The scientists showed that Treg cells prevent this destructive response after they and the T helper cells independently interact with dendritic cells. The mechanism of this protective effect remains a major immunology puzzle. The new study suggests that regulation may occur through direct or indirect modification of the critical antigen-presenting dendritic cells ?the scavenger cells of the immune system that pick up and display self proteins that trigger the auto-aggressive T cell response, said Jeffrey Bluestone, PhD, distinguished professor of metabolism and endocrinology at UCSF and senior author on the paper. Bluestone directs the UCSF Diabetes Center.

The research provides a "blueprint" of what immune regulation looks like, says study co-author Max Krummel, PhD, UCSF assistant professor of pathology whose lab adapted the new two-photon microscopy technique for visualizing cell-cell i
'"/>

Source:University of California - San Francisco


Page: 1 2 3 4

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
(Date:12/5/2014)... VIEW, Calif. , Dec. 4, 2014 /PRNewswire/ ... safety has boosted investments in new testing and ... has also given rise to a range of ... by the requirements of Generation Y, which is ... technologies. As a result, product development strategies of ...
(Date:12/3/2014)... As part of our commitment to offering ... to announce the release of a new reader that ... workforce data that they need. The Atlas ... existing readers. Many such devices have serious shortcomings when ... Older models force users to navigate numerous complicated steps ...
(Date:11/21/2014)... Wash. , Nov. 20, 2014 C-Labs ... for the Internet of Things (IoT), today announced the ... of chief operating officer. Previously a strategic advisor to ... finance, and operations. Mr. Traynor is based out of ... . He reports to Chris Muench , Chief ...
Breaking Biology News(10 mins):Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Inception Technologies to Release New Biometric Reader 2C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2
... Scientists at IRB Barcelona have discovered that some brain ... use the genetic programme of germline cells to grow. ... brains. This finding demonstrates that these genes are crucial for ... is published today in the prestigious journal Science . ...
... study was carried out to examine the extent ... or insulin resistance in primary cultures of human ... cytokine elevated in the plasma and adipose tissue ... adipocytes were pretreated with quercetin and trans-RSV followed ...
... have succeeded in plugging a metal atom into a ... could be a key in opening up new production ... of organic compounds, which in turn might have implications ... is the first to determine the precise structure of ...
Cached Biology News:Some brain tumors mimic the genetic program of germline cells 2Study on effects of resveratrol and quercetin on inflammation and insulin resistance 2Milestone: A methane-metal marriage 2Milestone: A methane-metal marriage 3Milestone: A methane-metal marriage 4
(Date:12/22/2014)... The Center for Professional Innovation ... training across the life sciences industry, has partnered with ... to provide the organization's members with discounted classroom courses, ... the more than 350 sessions across 80 course titles. ... when registering for a public course at ...
(Date:12/22/2014)... 2014 GenomeDx Biosciences today announced that a ... a genomic test for prostate cancer, was able to ... by radical prostatectomy without adjuvant therapy. Although rapid metastasis ... using tumor genomics to identify these men who have ... important advance. The study has been published online ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 Fertility Associates ... Donor Egg Bank USA , a network of more ... Through this partnership, patients have fast access to a ... vitro fertilization, IVF . Fertility Associates of Memphis is ... this fertility treatment option. , Dr. William Kutteh ...
(Date:12/19/2014)... -- Naurex Inc., a biopharmaceutical company leveraging its unique ... central nervous system, today announced that Norbert Riedel ... at the 33 rd annual J.P. Morgan Healthcare ... p.m. PST on Tuesday, January 13, 2015, at the ... About Naurex Inc. ...
Breaking Biology Technology:CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 2Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 3Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3Naurex to Present at 33rd Annual J.P. Morgan Healthcare Conference 2
... 2011  Hybrid Fuels, Inc., (Pink Sheets: HRID ... its new CEO and President.  Mr. Cadena was the ... EMG Marketing Solutions, and will be instrumental in implementing ...     Mr. Cadena has over 25 years ...
... Skills Related to Nutrition Care in ... Top-Tier Organization Elsevier/MC Strategies , a ... healthcare organizations announced today its collaboration with the ... to review and amend the nutrition-related skills in Mosby,s ...
... Energy, Inc., one of the world leaders in ... Acids Research Journal has published its white ... manipulation in algae."  As the site of photosynthesis in ... producing organic molecules from atmospheric carbon dioxide (CO2) ...
Cached Biology Technology:Hybrid Fuels, Inc. Appoints Industry Expert as New CEO 2Elsevier Collaborates with the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) 2Elsevier Collaborates with the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) 3Nucleic Acids Research Journal Publishes Sapphire Energy Peer-Reviewed Research Paper on a Chloroplast Genome From Green Algae 2
... quadrupole 1200L sets the new standard ... - incorporating the latest technologies and ... chromatography analytical needs. The Atmospheric ... Transmission Quadrupole Analyzer provide superior selectivity ...
Human GFR alpha-4 Affinity Purified Polyclonal Ab...
Human Siglec-9 Biotinylated Affinity Purified Pab...
Human MFRP MAb (Clone 291218)...
Biology Products: