Navigation Links
Scientists directly view immune cells interacting to avert autoimmunity

Using a new form of microscopy to penetrate living lymph nodes, UCSF scientists have for the first time viewed immune cells at work, helping clarify how T cells control autoimmunity.

The technique, known as two-photon laser-scanning microscopy, was able to focus deep within the lymph node of a diabetic mouse, allowing the researchers to show that immune cells known as T regulatory, or Treg, cells control the destructive action of rogue autoimmune cells when each of the two cell types interact with a third kind of cell.

The role of the third cell type -- the antigen-presenting dendritic cell -- in preventing autoimmune attacks of healthy tissue has been a focus of intense research over the last 15 years. The new study supports one contending hypothesis: It is not the interaction between the two types of T cells, but rather the interaction of each with the dendritic cells that leads to protection from autoimmune assaults.

Analyzing these physical interactions experimentally in living organs or even in cell cultures has been impossible before now, the scientists note. Their long-term aim is to use such imaging to diagnose immune diseases such as type 1 diabetes, and to further develop therapies that act at the level of T cell interactions.

The research, published online this week in Nature Immunology, includes online videos of these immune cell interactions ?the first time this has been accomplished.

The scientists used fluorescent dye to mark different types of cells so they could directly observe the interactions of the key cell types involved in initiating autoimmune attacks and the control of their actions by therapeutic regulatory T cells.

The "nonobese diabetic" (nob) mouse model used in the research is considered the "prototypic" model for human type 1 diabetes, said Qizhi Tang, PhD, UCSF adjunct assistant professor in the UCSF Diabetes Center and lead author of the paper. The researchers expect the findings from t
'"/>

Source:University of California - San Francisco


Page: 1 2 3 4

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
(Date:7/10/2014)... , July 2, 2014 NXT-ID, Inc., (OTCQB: NXTD) a biometric ... CEO Mr. Gino Pereira was interviewed on July ... Tampa Florida . Mr. Pereira discusses the ... Cedric Harris and how the Wocket™ aims to replace ... Cedric Harris tells Gino he has ...
(Date:7/10/2014)... , July 7, 2014 Fingerprint Cards, ... major design win (DW). A Chinese Top 5 smartphone OEM ... start of mass production in October 2014.   ... Top 5 smartphone OEM, which has a planned date for ... target sales volume for this phone of 3 million units. ...
(Date:7/10/2014)... Intelligence today released forecasts from "The Global National eID ... for National Electronic ID (eID) programs will generate $54 billion ... number of National eID cards in circulation will double from ... with its vast population, will dominate the market representing nearly ... Europe trails a distant second at 11%. ...
Breaking Biology News(10 mins):Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 2Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 4FPC Wins DW for 1021 Touch Sensor for Flagship Smartphone from Chinese Top 5 Smartphone OEM 2National Electronic ID Programs Generate $54 Billion Between 2013 and 2018 with 3.5 Billion National eID Card Holders Worldwide 2
... or maybe it is 639. Or maybe it is 850. Or ... it is a lot. Stanford bioengineer Scott Delp knows; he has ... application that helps medical professionals and bioengineers study, diagnose and correct ... are more than 100 muscles, virtually every one necessary to maintain ...
... supporting the age-old wisdom that cranberries, whether in sauce ... wondered if there was an element of the berry ... would be as effective as drinking the juice or ... Worcester Polytechnic Institute (WPI) helps to answer that question. ...
... and Spanish scientists studying the use of stem cells ... evidence to show that meninges, the membrane which envelops ... self-renewing stem cells. The research, published in STEM ... central nervous system injuries; advancing research into new treatments ...
Cached Biology News:OpenSim open-source software from Stanford accurately models human motion 2OpenSim open-source software from Stanford accurately models human motion 3More power to the cranberry: Study shows juice better than extracts at fighting infections 2Evidence for spinal membrane as a source of stem cells may advance spinal cord treatment 2
(Date:7/10/2014)... Terascala, the industry leader in ... a former vice president of product management for Flexera ... of marketing. Terascala’s software when combined with leading compute ... highest performance and most reliable solutions for processing big ... channel expansion and broaden its product portfolio. His leadership ...
(Date:7/10/2014)... Angeles, CA (PRWEB) July 10, 2014 ... and Bioanalytical techniques during 18-20 August, 2014 at Double ... critically review the recent developments in Analytical & Bioanalytical ... the globe. , Speaking on this occasion, Dr. Srinubabu ... Analytica Acta conference is a remarkable one in ...
(Date:7/10/2014)... POINT, Ind. , July 10, 2014 ... expanded its use of capnography for respiratory ... growing group of healthcare leaders in embracing ... measures how effectively patients are breathing and ... depression occurs. By measuring the amount of ...
(Date:7/10/2014)... 10, 2014 /PRNewswire-iReach/ -- Tute Genomics, the ... announced an agreement with Lineagen, Inc., to ... NextStep Dx PLUS.  Lineagen, focused on ... disorders, currently offers FirstStep Dx PLUS, ... used by healthcare providers as a first-line ...
Breaking Biology Technology:Terascala Expands Executive Team 2Terascala Expands Executive Team 3A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4
... 6, 2008 at 3:00 p.m. EDT, ... Inc., a,biopharmaceutical company developing genetically-targeted therapies for,heart ... that,Richard Brewer, the company,s president and chief ... chairman and chief science and medical,officer, will ...
... 2 The Blood and Marrow Stem Cell,Transplantation ... Hackensack,University Medical Center is the first in the ... stem cell transplantation from The,Joint Commission, the nation,s ... Blood and Marrow Transplantation Program also,recently became the ...
... TorreyPines Therapeutics, Inc.,(Nasdaq: TPTX ) today announced ... with the U.S. Food and Drug Administration (FDA) on,September ... II data, the FDA agreed,that TorreyPines may initiate a ... also confirmed that the required thorough QT/QTc study,for tezampanel ...
Cached Biology Technology:ARCA biopharma to Present at JMP Securities Healthcare Focus Conference 2ARCA biopharma to Present at JMP Securities Healthcare Focus Conference 3ARCA biopharma to Present at JMP Securities Healthcare Focus Conference 4ARCA biopharma to Present at JMP Securities Healthcare Focus Conference 5Stem Cell Transplantation Program at Hackensack University Medical Center: First in Nation to Receive Joint Commission Certification for Quality and First in New Jersey to be Named a Blue Distinction(R) Center for Specialty Care. 2Stem Cell Transplantation Program at Hackensack University Medical Center: First in Nation to Receive Joint Commission Certification for Quality and First in New Jersey to be Named a Blue Distinction(R) Center for Specialty Care. 3TorreyPines Therapeutics Reports Successful End-of-Phase II Meeting With FDA for Tezampanel 2TorreyPines Therapeutics Reports Successful End-of-Phase II Meeting With FDA for Tezampanel 3TorreyPines Therapeutics Reports Successful End-of-Phase II Meeting With FDA for Tezampanel 4
... derivatives that have mutations in both the ... genes, which greatly enhances disulfide bond formation ... expression in Origami(DE3) yielded 10-fold more active ... overall expression levels were similar (1). Origami ...
... Blunt TOPO PCR Cloning ... designed for cloning and ... PCR products. The pCR4Blunt-TOPO ... Cloning and greater than ...
... CELLection Dynabeads (4.5 m) coated with the ... EpCAM and DNase Releasing Buffer. For ... tumour cells directly from blood, bone marrow ... enriched from bone marrow. Enriched cells are ...
Recombinant Human CCL21/6Ckine (Mucin Stalk Chimera)...
Biology Products: