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Scientists design potent anthrax toxin inhibitor

Thus, combining antibiotics with a toxin inhibitor might act synergistically to lessen or halt anthrax symptoms, notes Dr. Kane.

Using the same technique of placing multiple peptides on a liposome, the researchers also created a polyvalent inhibitor of cholera toxin that functioned well in test-tube experiments.

In the next phase of their research, Drs. Kane and Mogridge and their colleagues plan to test the action of their inhibitor in animals after infecting them with B. anthracis and allowing the disease process to begin. They also will evaluate the inhibitor with and without adjunct antibiotic therapy.


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Source:NIH/National Institute of Allergy and Infectious Diseases


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