Navigation Links
Scientists design potent anthrax toxin inhibitor

Scientists funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), have engineered a powerful inhibitor of anthrax toxin that worked well in small-scale animal tests.

"This novel approach to the design of anthrax antitoxin is an important advance, not only for the value it may have in anthrax treatment, but also because this technique could be used to design better therapies for cholera and other diseases," says NIH Director Elias A. Zerhouni, M.D.

The research appears in the April 23 online edition of the journal Nature Biotechnology.

Led by NIAID grantees Ravi S. Kane, Ph.D., of Rensselaer Polytechnic Institute, in Troy, NY, and Jeremy Mogridge, Ph.D., of the University of Toronto, the investigators built a fatty bubble studded with small proteins that can cling tightly to the cell membrane receptor-binding protein used by anthrax toxin to gain entry into a host cell.

The protein-spiked fatty bubble, or "functionalized liposome," hampers a critical early step in the assembly process that anthrax toxin must undergo to become fully active. In test-tube experiments, the inhibitor, which is covered with multiple short proteins (peptides), was 10,000 times more potent than unattached peptides.

"If the effectiveness of anthrax inhibitors designed in this fashion is confirmed by additional testing, they could one day be important adjuncts to standard antibiotic therapy for the treatment of inhalation anthrax," says NIAID Director Anthony S. Fauci, M.D.

The spore-forming bacterium Bacillus anthracis produces a toxin that causes anthrax symptoms. Antibiotics are used to treat anthrax, but even with such therapy, inhalation anthrax, the most severe form of the disease, has a fatality rate of 75 percent.

"There would be real value to having an additional form of therapy available to physicians confronting a case of inhalation anthrax," notes Phillip
'"/>

Source:NIH/National Institute of Allergy and Infectious Diseases


Page: 1 2 3

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
(Date:7/24/2008)... ,, Well inside the Arctic Circle, scientis...n anyone has ever seen before. The cluster of five... are venting water as hot as 570 F., Dissolved ...s the icy cold of the deep sea have, over the year...e of the most massive hydrothermal sulfide deposit...
(Date:7/24/2008)... , An infection due to a virus called cytomegalov...h compromised immune systems, can also affect hosp...stem problems, University of Washington researcher...h longer hospital and intensive-care unit (ICU) st...study, published July 23 in JAMA , the Journal o...
(Date:7/24/2008)... , , Irvine, Calif., July 24, 2008 Adult stem c...an is commonly believed, and with proper stimulati...se lost to disease or injury, a study by UC Irvine... that the true stem cells in the mammalian brain a... the brain and spinal cord, rather than cells in t...
(Date:7/24/2008)... , , NEW YORK, July 24, 2008 In the life of a c... the cell is fated to pause and repair itself, com...ng to cancer. In a new study, published in the Jul...Medical Center have identified a way that cells re... proteins for disposal. The finding points to a ne...
Breaking Biology News(10 mins):Scientists break record by finding northernmost hydrothermal vent field 2Scientists break record by finding northernmost hydrothermal vent field 3CMV infections affect more than just patients with compromised immune systems, researchers find 2Adult stem cells activated in mammalian brain 2Adult stem cells activated in mammalian brain 3A new cellular pathway linked to cancer is identified by NYU researchers 2Occlutech Clarifies Statement Regarding Favourable Opinion Obtained From AIPPI With Regard to Patents Held by AGA Medical 4680 1Occlutech Clarifies Statement Regarding Favourable Opinion Obtained From AIPPI With Regard to Patents Held by AGA Medical 4680 2APIC Conference to address new CMS regulations 17104 1APIC Conference to address new CMS regulations 17104 2Inaugural Kirkham Gold Medal presented to expert on soil physics 2942 1Inaugural Kirkham Gold Medal presented to expert on soil physics 2942 2Growth Hormone is Used to Treat Twice as Many Short Boys Than Girls in the U S and Asia 3B Gender Difference is Smaller in the Rest of the World 17099 1Growth Hormone is Used to Treat Twice as Many Short Boys Than Girls in the U S and Asia 3B Gender Difference is Smaller in the Rest of the World 17099 2Growth Hormone is Used to Treat Twice as Many Short Boys Than Girls in the U S and Asia 3B Gender Difference is Smaller in the Rest of the World 17099 3Growth Hormone is Used to Treat Twice as Many Short Boys Than Girls in the U S and Asia 3B Gender Difference is Smaller in the Rest of the World 17099 4
...rd off a cliff. Another prefers to read a book and...rences exist is a mystery, but for the first time ...lanation behind risk-seeking behavior. , Scientis...found that a specific neurodevelopmental gene, cal...lmond-shaped area of the brain called the amygdala...
...ficial shark skin could help ships sailing smoothl...s on ship hulls is a major cause of increased ener...a structural design that prevents this so called ,...of Applied Sciences, Bremen, Germany, is presentin...skin in a new anti-fouling strategy at the Society...
...supply needed by 2020 just to maintain consumption...ng the poor and for helping Africa cope with the h... like HIV and AIDS, the New Partnership for Africa...artners are making an urgent appeal to boost the c...ribution of fisheries to economic growth and food ...
... of Alberta have discovered that chickens raised f...he nutrients they eat towards themselves or their ..., is a headache for producers who must figure out ...ion" nutrients needed for egg production into thei...elfish with their nutrients, and continue growing,...
Other Biology News:Study identifies gene in mice that may control risk-taking behavior in humans 2Study identifies gene in mice that may control risk-taking behavior in humans 3Leptin-signaling Protein Maintains Normal Body Weight And Energy Balance In Mice 2Leptin-signaling Protein Maintains Normal Body Weight And Energy Balance In Mice 3Leptin-signaling Protein Maintains Normal Body Weight And Energy Balance In Mice 4Leptin-signaling Protein Maintains Normal Body Weight And Energy Balance In Mice 5What comes first…the chicken, the egg, or the bad attitude? 2
(Date:7/24/2008)...R and SAN DIEGO, July 24 / ...age developer of drugs for infectious,diseases, ad...ed a general,meeting of shareholders (the "Meeting...ober 31, 2008, at 102 - 2389 Health Sciences Mall,... respect to the Meeting will be,provided in an Inf...
(Date:7/24/2008)...O, July 24, 2008 /- NuVasiv... focused on developing products for,minimally disr...d today,that it has completed the previously annou...s from Osiris Therapeutics, Inc. (Nasdaq: OSIR ) ...-based contingent payments not to,exceed $50 milli...
(Date:7/24/2008)...TY, Calif., July 24 /- Abax...any manufacturing point-of-care,blood analysis sys...st,fiscal quarter ended June 30, 2008., Quarter...on, up 7% over last year,s comparable quarter. --... of 804 units, up 127 units or 19% over last y...
(Date:7/24/2008)...s hospital physicians, pulmonary and critical care...bout overuse of antibiotics, DURHAM, N.C., July 2...o,surveys, fielded during conferences of the Ameri...ine, that show how hospitalists, pulmonary and,cri...us in their view that,new methods and technologies...
Breaking Biology Technology:NuVasive Completes Acquisition of Osteocel Biologics Business 2NuVasive Completes Acquisition of Osteocel Biologics Business 3NuVasive Completes Acquisition of Osteocel Biologics Business 4NuVasive Completes Acquisition of Osteocel Biologics Business 5Abaxis Reports Financial Performance for the First Quarter of Fiscal 2009 2Abaxis Reports Financial Performance for the First Quarter of Fiscal 2009 3Abaxis Reports Financial Performance for the First Quarter of Fiscal 2009 4Abaxis Reports Financial Performance for the First Quarter of Fiscal 2009 5Abaxis Reports Financial Performance for the First Quarter of Fiscal 2009 6Abaxis Reports Financial Performance for the First Quarter of Fiscal 2009 7Abaxis Reports Financial Performance for the First Quarter of Fiscal 2009 8U.S. Clinicians Indicate a Strong Need for New Tools to Combat Sepsis 2U.S. Clinicians Indicate a Strong Need for New Tools to Combat Sepsis 3
...here are millions of very expensive, well-designed...nformation to offer with great graphic illustratio...xperiences and capabilities with upfront personali...at is missing is the proof about who really are th...nt the staff and their true particulars. This info...
... a departure from her series of entrepreneurial pr...ers , by Paul Graham, which was published by O,Re...opular. Paul Graham thinks this is a good thing. ,...a young Paul Graham sitting in his junior high sch...to popularity. The tables favored by football play...
...tland, Wis. The Columbus Children,s Hospital ann...nt with Camtronics Medical Systems Ltd. to purchas...l be implemented in the Columbus Children,s Heart...d adults with hereditary heart defects. , ,The cho... administrative and clinical needs, looking specif...
...arry Peterson, chair of Princeton,s computer scien...im of its own success. , ,In a seminar Tuesday eve... computer science department, a leading Princeton ...er friendly to experimentation. , , Larry Peterson...t, directs PlanetLab , a distributed network of c...
Other Biology Technology:Whats Hush-Hush Marketing? 2Whats Hush-Hush Marketing? 3Hackers & Painters: Big Ideas from the Computer Age 2Hackers & Painters: Big Ideas from the Computer Age 3Hackers & Painters: Big Ideas from the Computer Age 4Hackers & Painters: Big Ideas from the Computer Age 5Children's Hospital chooses Camtronics for cardiology IT system 2UW attracts speaker on network that could supplant Internet 2UW attracts speaker on network that could supplant Internet 3UW attracts speaker on network that could supplant Internet 4
Request Info
Mouse Aminopeptidase P2/XPNPEP2 Biotinylated Aff Pur PAb Keywords: AminopeptidaseP2, Metalloproteinase, Metalloprotease, X-Prolyl Aminopeptidase 2, X-Pro Aminopeptidase 2, Membrane-bound Prote
Request Info
AGAROSE PREP, 50G, 1 EA. Category: Genephor Precast Gels.
Biology Products: