Navigation Links
Scientists create dual-modality microbeads to improve identification of disease biomarkers

heir size, giving the beads a unique optical signature. Having different color beads allows the researchers to detect several target molecules at the same time in the same liquid sample.

"We use the quantum dots to create a set of beads that are unique and can be distinguished from each other. It’s similar to bar-coding -- once you barcode the beads and put them in the urine or blood sample, you can remove them and decode what proteins or viruses have attached to individual beads based on their spectral signature," explained Sathe.

The process of creating these beads is quite simple, according to Sathe. The surface of the beads contains a long-chain carbon molecule that makes the beads hydrophobic, meaning they repel water. The beads are dissolved in butanol and washed several times. Then the beads are counted and optical and magnetic nanocrystals are added to the suspension either simultaneously or sequentially. __IMAGE_3

After 15-20 minutes, the butanol is removed to get rid of any remaining nanoparticles that didn’t get incorporated into the beads and the beads are washed with ethanol. Then the beads are coated with a polymer that creates a hydrophilic surface on the beads. This allows the beads to be functionalized by adding antibodies or DNA molecules to the surface that will capture the target molecules.

These beads are dual-function -- both optical and magnetic -- but according to Sathe, more functions can be added to the beads. "Adding them is as easy as adding the nanoparticles into the solution. You just have to make sure the nanoparticle surface is hydrophobic so that it interacts with the beads," said Sathe.

The primary biomedical applications for this new technology will be to detect cancer and neurological diseases by identifying certain molecules present in human blood or urine that indicate specific diseases, according to Nie, who is also professor of biomedical engineering, chemistry, materials sc
'"/>

Source:Georgia Institute of Technology Research News


Page: 1 2 3

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
(Date:12/19/2014)... , Dec. 18, 2014 Research and Markets ( ... Market Monitor: North America Perimeter Security Systems Market" report ... The North American perimeter security market is estimated ... 2019. Although the U.S. market holds a larger share in ...
(Date:12/17/2014)... Dec. 15, 2014 The Defense Logistics Agency is ... and prevent counterfeit microcircuits from entering into its supply ... in-house microcircuit anti-counterfeit initiative dubbed DNA marking. The capability ... their reliability throughout the supply chain. The new quality ...
(Date:12/17/2014)... Dec. 16, 2014  Automation is fundamentally transforming the travel ... international borders. Over the past decade, ePassports, biometric readers, ... self process through border control via eGates and Automated ... airports, seaports, and land borders across the globe. ...
Breaking Biology News(10 mins):Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2
... part in the National Science Foundation,s (NSF) Faculty ... additional distinction as winners of Presidential Early Career ... 2006 competition. The PECASE program recognizes outstanding ... show exceptional potential for leadership at the frontiers ...
... wildfires can contribute as much as vehicles to carbon ... highly variable. New research published in the online open ... and suggests fires will complicate emissions monitoring and modelling ... Atmospheric Research and Jason Neff of the University of ...
... State University have designed a revolutionary laser technique which ... damaging human cells and may also help reduce the ... The research, published on Thursday November 1 in ... discusses how pulses from an infrared laser can be ...
Cached Biology News:Beginning scientists receive presidential awards 2Beginning scientists receive presidential awards 3Beginning scientists receive presidential awards 4Beginning scientists receive presidential awards 5Beginning scientists receive presidential awards 6Beginning scientists receive presidential awards 7US faces burning emissions issue 2
(Date:1/22/2015)... Dr. Greg Leyer of UAS Labs recently was ... Pre-Conference seminar on probiotics in San Diego, CA. , ... conference for health care professionals. This year’s pre-conference seminar was ... in health. Dr. Leyer spoke about the emerging topics and ...
(Date:1/22/2015)... Selexis SA, a serial innovation company ... (RCBs) used for drug discovery to commercial manufacturing, announced ... Next-Generation Sequencing (NGS) data packages. The NGS ... by ensuring the integrity of the gene, validation of ...
(Date:1/22/2015)... 22 de enero de 2015  El Dr. Paul ... llamada a nominaciones para 2015. Este prestigioso premio reconoce ... tiene el potencial para hacer, contribuciones destacadas para la ... hasta el 15 de marzo de 2015 a través ...
(Date:1/22/2015)... Calif. , Jan. 22. 2015  Varian Medical Systems (NYSE: ... software, has been honored for its commitment to sustainability with ... companies. Varian is the highest ranked healthcare equipment company among ... today during the World Economic Forum at Davos, ...
Breaking Biology Technology:Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4Varian Honored Among World's 100 Most Sustainable Corporations 2
... SAN DIEGO, Feb. 9 PacificGMP, the ... manufacturing for its client partners, announced today ... with LigoCyte Pharmaceuticals, Inc. Under the collaborative ... banks and will provide storage services under ...
... Cancer Clinics of Excellence, LLC, the nation,s only ... of its 62nd comprehensive Evidence-Based Treatment Protocol covering ... the 4th Annual Community Oncology Conference today. "Our ... prepared to launch the protocols across its network ...
... Women Detect Serious Health Problems While Making Charitable DonationsSANTA ... hurts. But when it comes to women,s health, it,s ... in the United States dies of heart disease. Although ... women, most people fail to make the connection between ...
Cached Biology Technology:PacificGMP and LigoCyte Pharmaceuticals Announce cGMP Manufacturing Collaboration 2Cancer Clinics of Excellence (CCE) Releases 62nd Evidence-Based Treatment Protocol 2BioIQ Supports American Heart Month to Raise Awareness About Heart Disease, the #1 Killer of Women 2