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Scientists crack code for motor neuron wiring

cuit, the better chance there is of developing regenerative strategies to restore motor function in a precise way," Jessell continued. "And in motor neuron degenerative diseases, it may not be enough make new motor neurons; they have to connect to the right muscle target in order to restore motor function. Understanding how Hox proteins control circuit formation in the spinal cord should provide an important basic framework for approaching these clinical issues.

"Thus, while these are basic studies on circuitry in the central nervous system, I think they offer the potential of understanding circuits in sufficient detail to guide approaches to therapy, in a clinical context," said Jessell.


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Source:Howard Hughes Medical Institute


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