Navigation Links
Scientists at Galileo Pharmaceuticals confirm inflammatory response linked to glucose levels

ease and put them together."

Kosik and his team chose to focus on the neurofibrillary tangles of neurons in the brain that, along with senile plaques, characterize Alzheimer's disease. The tangles are made of "tau," a protein that is also present normally in the brain.

"Tau goes wrong and becomes pathological when it becomes intensely phosphorylated," said Kosik. "This means that many phosphate groups attach to tau--modify it--and cause it to become dysfunctional."

The culprit is an enzyme, called CDK5, that attaches the phosphate to the tau protein, facilitating the disease process. The researchers set out to find a way to inhibit this enzyme, to keep it from putting any phosphate on tau.

In the laboratory, they purified the enzyme and purified tau protein, and watched tau get phosphorylated by the enzyme. They then performed a library search of small molecules (58,000 of them) in an attempt to find those that would prevent phosphorylation. Small molecules are preferred because they are more easily used as a drug since they can get through the body and into cells. It is also important to find molecules that will cross the blood brain barrier.

They then set up a test of nearly 400 small molecules that fit their criteria. The test results showed three small molecules that can inhibit the enzyme. These are candidates for development as drugs.

Kosik explained that proteins are strings of amino acids folded into small globs. All proteins that happen to be an enzyme involved in phosphorylation have one thing in common. They have a pocket that is almost always in the same place and this is where the phosphate attaches to the enzyme, in this case CDK5. To get a molecule that specifically prevents the enzyme from binding at the pocket is difficult.

Of the three compounds that the research group found, the scientists were able to locate where they bind. They found that one binds in the pocket, another binds at the edge
'"/>

Source:AB Corporate Communications


Page: 1 2 3

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
(Date:7/28/2014)... for Biologically Inspired Engineering at Harvard University today ... commercialized by a newly formed private company to ... medicine products. The announcement follows a ... Development (OTD) and the start-up Emulate Inc., relating ... Organs-on-Chips platform. , "This is a big ...
(Date:7/27/2014)... nicotine and cotinine, a metabolite of nicotine, can potentially ... smoke. , The carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone or NNK is produced ... up in the tobacco smoke. Once inhaled, it is ... activated by a variety of enzymes called Cytochrome P450 ... can partially interfere with the activation of NNK, and ...
(Date:7/27/2014)... mayfly in the southern Western Ghats, a mountain range along ... first time that any mayfly belonging to the genus ... new species, called Labiobaetis soldani , "is named in ... the understanding of the Ephemeroptera of Palaearctic and Oriental realms," ... new mayfly in the Journal of Insect Science . ...
Breaking Biology News(10 mins):Wyss Institute's technology translation engine launches 'Organs-on-Chips' company 2Wyss Institute's technology translation engine launches 'Organs-on-Chips' company 3Nicotine found to inhibit DNA-strand break caused by a certain carcinogen in smoke 2
... senior female family members should play a key role in ... societies. However, they are often overlooked by health organisations that ... as an obstacle to promoting good nutrition and health practices. ... review published in the January issue of Maternal and ...
... This press release is available in German . ... as tsunamis, landslides, and ground settlements, caused a damage of ... the so far highest economic losses due to earthquakes. This ... from the Center for Disaster Management and Risk Reduction Technology ...
... Springer celebrates its 50,000th eBook, available on ... milestone underscores Springer,s position as the largest eBook ... world,s most comprehensive online collection of science, technology ... In addition, as announced in October 2011, ...
Cached Biology News:Research highlights key role grandmothers play in mother and child nutrition and health 2Research highlights key role grandmothers play in mother and child nutrition and health 3Japan and New Zealand were hit hardest by earthquakes 2SpringerLink now offers more than 50,000 eBooks 2
(Date:7/28/2014)... (PRWEB) July 28, 2014 The National ... in Muncie IN, is pleased to announce that it ... National Museum of the United States Air Force. , ... year-long process that concluded this spring with an on-site ... Dayton, OH museum. , The National Museum of ...
(Date:7/25/2014)... 2014 "Ischemic Stroke and Cerebral ... data on the Ischemic Stroke and Cerebral Stroke ... and data relating to the clinical trials on ... global Ischemic Stroke Research Report 2014 at: ... the trial numbers and their recruitment status as ...
(Date:7/25/2014)... -- Trillions of bacteria live in each person,s digestive ... digest food and stave off harmful infections, but their ... To help shed light on the role of these ... professor Eric Alm recently tracked fluctuations in the bacterial ... The findings, described in the July 25 issue of ...
(Date:7/25/2014)... 25, 2014 Research and Markets ... Metabolomics Market 2014-2018" report to their offering. ... Metabolomics or Metabonomics is the scientific study ... a new experimental technique that is being widely ... Metabolites are small molecules that are present in ...
Breaking Biology Technology:AMA’s National Model Aviation Museum Granted Full Civilian Museum Certification by the National Museum of the United States Air Force 2Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 2Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 3Monitoring the rise and fall of the microbiome 2Monitoring the rise and fall of the microbiome 3Global Metabolomics Market 2014-2018: Key Vendors are Agilent, Bio-Rad, Bruker, Human Metabolome and Metabolon 2
... THE WOODLANDS, Texas, Oct. 4 Lexicon,Pharmaceuticals, Inc. (Nasdaq: ... Ph.D., Lexicon,s president and chief executive officer, will present,at ... Francisco, California,on Thursday, October 11, 2007 at 11:00 a.m. ... may be accessed on its,corporate website at http://www.lexpharma.com ...
... Oct. 4 Genzyme Corp.,(Nasdaq: GENZ ) ... market,Elaprase(R) (idursulfase) in Japan for the treatment of ... by Shire Human Genetic,Therapies Inc., and Genzyme is ... countries under an agreement with Shire. Genzyme intends,to ...
... CLARA, Calif., Oct. 4 Coherent, Inc.,(Nasdaq: COHR ... 2007, it,received an additional NASDAQ Staff Determination letter indicating ... listing,requirements as set forth in Marketplace Rules 4350(e) and ... of stockholders during its fiscal,year ended September 30, 2007. ...
Cached Biology Technology:Lexicon Pharmaceuticals to Present at Bio InvestorForum 2Genzyme Receives Approval to Market Elaprase(R) in Japan 2Genzyme Receives Approval to Market Elaprase(R) in Japan 3Genzyme Receives Approval to Market Elaprase(R) in Japan 4Coherent, Inc. Receives Expected Letter from NASDAQ 2
... The Mini-PROTEAN 3 Dodeca cell with multi-casting ... of up to 12 mini format handcast (8.3 ... cm) gels. The cell requires 3.4-4.4 L of ... cooling coil that attaches to an external refrigerated ...
...
... has been developed to significantly increase the ... Stability is increased at room temperature ... This product is subjected to 0.2 ... azide. This formulation insures consistently high ...
...
Biology Products: