Navigation Links
Science study holds implications for gene therapy and stem cell biology

A study in the May 20 issue of Science holds mixed blessings for scientists who follow research in gene therapy and stem cell biology. The study, conducted by scientists from Cincinnati Children's Hospital Medical Center, and Hannover Medical School and Hamburg University in Germany, reveals important evidence that tells us more about how blood forming stem cells regenerate. On the other hand, scientists offer caution in regards to the side effects associated with genetic engineering of stem cells.

The study, whose lead author is Christopher Baum, MD, an adjunct associate professor of experimental hematology at Cincinnati Children's, is one of a family of studies on using disabled retroviruses as gene transfer vectors. To date, disabled retroviruses have mostly been tested experimentally in laboratory settings but are also being tested in well-controlled clinical trials to treat severe inborn diseases or cancer in humans.

Retrovirus-based gene transfer vectors are partially defective retroviruses that integrate into the genome of a cell, thus potentially increasing the activity of neighboring genes.

A previous study by Dr. Baum and team revealed that the insertion of several such retrovirus vectors into a single blood-forming stem cell can lead to leukemia in mice, because several "signaling" genes were activated that worked in concert to cause disease.

The question left: What happens if only one of these genes is activated in a stem cell?

This question is addressed in the newly published Science study. Researchers found that they could use the random genome insertion of disabled retroviruses as a tool to discover genes that enhance the fitness of stem cells. Such genes are of great interest for regenerative medicine because they can improve the prospects of stem cell-based therapies. Stem cells are very rare in the body and typically need to be multiplied for medical use. The genes that the researchers found to be marked and a
'"/>

Source:Cincinnati Children's Hospital Medical Center


Page: 1 2 3

Related biology news :

1. Papers of DNA Pioneer and Nobel Laureate Francis Crick Added to National Library of Medicine’s Profiles in Science Web Site
2. Kinovate Life Sciences Launches Nittophase?High Performance Solid Support For Oligonucleatide Synthesis
3. Affymetrix Licenses Microfluidics Technology From Caliper Life Sciences
4. Scientists generate patient-specific stem cells, Science study says
5. TrueBlue Archive Will Store Raw Life Sciences Data for Proteomics and Drug Testing
6. Leprosy genome tells story of human migrations, French researchers report in Science
7. DOEs Office of Science sets up program to aid scientists displaced by Hurricane Katrina
8. Sciences Breakthrough of the Year: Watching evolution in action
9. Sangamo BioSciences demonstrates its ZFP treatment protects cells from HIV infection
10. Are U.S. Flu Death Figures More PR Than Science?
11. Study in Science holds promise for a new approach to drug therapy
Post Your Comments:
(Date:8/21/2014)... developed a novel and versatile modeling strategy to simulate ... materials as well as for studying polyelectrolytes, including DNA ... model much larger and more complex polyelectrolyte systems, and ... lead author of a paper on the work and ... Science and Engineering. "This is a big step forward ...
(Date:8/20/2014)... ITHACA, N.Y. In a study of 158 pregnant ... the craving and intentional consumption of ice, cornstarch, ... items, reports a new Cornell study. , Moreover, such ... teens who did not eat nonfood substances. , Pregnant ... low hemoglobin, which can lead to iron deficiency and ...
(Date:8/20/2014)... Issue Serious allergic reactions to food ... for some children.    What you should know ... allergies and this number may be increasing, especially among children. ... have food allergies.  The symptoms of allergic ... breathing difficulties and loss of consciousness. Symptoms can also develop ...
Breaking Biology News(10 mins):Researchers develop models to study polyelectrolytes, including DNA and RNA 2Pica in pregnant teens linked to low iron 2Information Update - Allergens and food safety at school - What's in your child's lunch? 2Information Update - Allergens and food safety at school - What's in your child's lunch? 3
... Spanish . , The potentially deadly yellow-fever-transmitting ... a compound called octenol as one way to find a ... scientists report. Scientists have long known that mosquitoes can ... Joseph Dickens and Jonathan Bohbot explains in greater detail how ...
... American Institute of Biological Sciences (AIBS) has selected Meredith ... Davis, Ryan Richards, a graduate student at the University ... student at the University of Rhode Island, to receive ... "AIBS is committed to fostering a productive ...
... Spring Harbor, NY -- One seemingly insurmountable obstacle to the ... wheat and rice is the dependence of those plants on ... and egg -- combine randomly to generate a genetically unique ... But what if plants like these could be engineered ...
Cached Biology News:ARS study provides a better understanding of how mosquitoes find a host 2AIBS names emerging public policy leaders 2AIBS names emerging public policy leaders 3CSHL-Mexican team coaxes sexually reproducing plant to brink of asexual reproduction 2
(Date:8/20/2014)... university inventions licensed to biotechnology firms has revealed ... open these roadblocks, the researchers suggest that better ... stage could lead to faster commercialization down the ... discoveries made in university laboratories and licensed to ... trials, which have a high failure rate. But ...
(Date:8/20/2014)... Neurotrope, Inc. (OTCQB: NTRP) today announced ... provide an update on Company activities. Access information:Date:Tuesday, ... 505-4369 (U.S. and Canada) or (719) 325-2315 Conference ... under "Investor Relations"The teleconference replay will be available ... 2014 at (888) 203-1112 (U.S. and ...
(Date:8/20/2014)... International Corporation (NASDAQ: PRXL ) announced today ... Conference in New York.  Ingo Bank , Senior ... a presentation on PAREXEL and discussing business developments at ... A live webcast of the discussion will be ... www.PAREXEL.com in the Upcoming Events portion of ...
(Date:8/20/2014)... 20, 2014 /PRNewswire-iReach/ -- A case study from ... the school,s bioengineering department and the Intel® Internet ... Software Academic Program, UCSD,s research focuses on exploring ... body.  Photo - http://photos.prnewswire.com/prnh/20140819/137540 ... work of Dr. Todd P. Coleman , ...
Breaking Biology Technology:Early bottlenecks in developing biopharmaceutical products delay commercialization 2Early bottlenecks in developing biopharmaceutical products delay commercialization 3Neurotrope To Host Conference Call 2PAREXEL International To Present At Baird Healthcare Conference 2Intel and University of San Diego Bioengineering Department Release Case Study on Health Sciences Research 2
... 14, 2012 AMPAC Fine Chemicals LLC (AFC), a ... APFC ), reports that it has joined Rx-360 ... biotech industry consortium that was founded by industry leaders ... and to assure the quality and authenticity of the ...
... 2012 Neuralstem, Inc. (NYSE Amex: CUR ) ... registered direct placement of 5,200,000 shares of common stock at ... with an exercise price of $1.02 per share and exercisable ... of five years. The company received aggregate gross proceeds of ...
... Ill., Feb. 13, 2012 Hospira, Inc.  (NYSE: ... injectable drugs and infusion technologies, today announced the hiring ... and compliance capabilities, including the appointment of Zena G. ... 2012. In this role, Ms. Kaufman will have overall ...
Cached Biology Technology:AMPAC Fine Chemicals Continues to Invest in Quality Systems 2AMPAC Fine Chemicals Continues to Invest in Quality Systems 3Neuralstem Announces Closing of $5.2-Million Registered Direct Offering 2Hospira Names Zena G. Kaufman Senior Vice President of Quality; Strengthens Quality and Compliance Capabilities With Addition of Top Industry Talent 2Hospira Names Zena G. Kaufman Senior Vice President of Quality; Strengthens Quality and Compliance Capabilities With Addition of Top Industry Talent 3Hospira Names Zena G. Kaufman Senior Vice President of Quality; Strengthens Quality and Compliance Capabilities With Addition of Top Industry Talent 4Hospira Names Zena G. Kaufman Senior Vice President of Quality; Strengthens Quality and Compliance Capabilities With Addition of Top Industry Talent 5
... Ligase catalyzes the formation of a phosphodiester ... in nicked duplex DNA molecules or between ... complementary strand at 45 - 65?. Tfi ... much higher temperatures than conventional DNA ligases, ...
... a unique β-agarose digesting enzyme developed at ... DNA and RNA from low melting point ... TBE, MOPS, or phosphate buffers. The gel ... TBE, MOPS, and phosphate electrophoresis buffers or ...
... Perhaps sheer in-house demand is causing shortages ... precious antibody. This can cause unwanted distractions, ... Receive royalties for your hard work ... let us build it up,and market it ...
... PBL's bioassays for interferons are cytopathic effect ... assays. Sample types include; tissue culture supernatents; ... In these assays, one unit is defined as ... reduce the cytopathic effect of viral infection by ...
Biology Products: