Navigation Links
Salmonella caught red-handed

Pathogens are becoming increasingly resistant to antibiotics, causing problems for therapy. Doctors need to have antibiotics available that work in new kinds of ways. The last few years of research have, however, found few such ways. One major difficulty for developers of antibiotics is choosing the proper point of attack against bacteria. There are hundreds of possible points of attack, according to genome analysis and laboratory culture experiments ?but validation in in vivo infection models is largely lacking.

Infection biologists and proteomics researchers have now identified all the proteins involved in Salmonella metabolic paths during an infection. Dirk Bumann of Hannover Medical School led a team including Daniel Becker, Claudia Rollenhagen, Matthias Ballmaier and Thomas Meyer of the Max Planck Institute for Infection Biology. They isolated Salmonella from infected mice. Proteomics researchers Matthias Selbach and Matthias Mann from the Max Planck Institute of Biochemistry then turned to highly-sensitive mass spectrometry to look at the protein mixture ?and discovered hundreds of different Salmonella metabolic path proteins. The scientists compared them with special protein databanks and identified possible points of attack for antibiotics.

Bumann and his team then examined what role these proteins play in a Salmonella infection. The scientists turned off genes responsible for the proteins to see how it affected the disease's progress. "Knocking out" the gene was equivalent to blocking its corresponding metabolic path, thereby simulating the effect of antibiotics. The analysis demonstrated the following: in the two possible types of salmonella-related illness (diarrhoea and typhoid), the bacteria is surprisingly unaffected by the blockade of several central metabolic pathways. The reason for this is redundant enzymes, as well as the host offering a wide range of nutrients, which means Salmonella does not depend on its own biosynthetic abiliti
'"/>

Source:Max-Planck-Gesellschaft


Page: 1 2

Related biology news :

1. Salmonella bacteria use RNA to assess and adjust magnesium levels
2. Salmonella survives better in stomach due to altered DNA
3. Natures process for nitrogen fixation caught in action
4. Prion disease treatable if caught early
5. Whats in the water? Estrogenic activity documented in fish caught in Pittsburghs rivers
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Salmonella caught red handed

(Date:11/18/2014)... , Nov. 17, 2014 The Parenteral Drug Association ... regulatory agencies will speak and at least seven more will ... at the Omni Shoreham Hotel in Washington D.C. ... again to have significant support from the regulatory agencies in ... Europe in our effort to help advance the ...
(Date:11/15/2014)... , Nov. 13, 2014  While we may still be ... McCoy used in "Star Trek" to gain instant access to ... to work with smartphones and tablets for monitoring and measuring ... healthcare world. This may seem a tad Orwellian to some, ... adopt some of these technological opportunities into their healthcare regime. ...
(Date:11/11/2014)... , Nov. 11, 2014  Forensicon, Inc., a ... firm, is pleased to announce the promotion of ... Director of Digital Forensics. In Schiff,s new role as ... the team of digital forensics examiners and provide leadership ... Photo - http://photos.prnewswire.com/prnh/20141110/157719 ...
Breaking Biology News(10 mins):FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2
... It,s a project 500 million years in the making. Only ... Jurassic Park, it,s happening in a lab at the Georgia ... Georgia Tech researchers have resurrected a 500-million-year-old gene from bacteria ... coli ) bacteria. This bacterium has now been growing for ...
... of researchers from Greece and Spain have managed to ... to their application in biotechnology, by using strawberry tree ... and very fast. Strawberry tree leaf ( Arbutus ... two ingredients scientists can now produce silver nanoparticles, a ...
... step,ATP splitting in membrane protein dynamically measured for the ... Biological Chemistry How a transport protein obtains ... has been tracked dynamically by RUB researchers. Using time-resolved ... bacterial membrane protein MsbA and its interaction partner ATP. ...
Cached Biology News:Giving ancient life another chance to evolve 2Silver nanoparticle synthesis using strawberry tree leaf 2ATP splitting in membrane protein dynamically measured for the first time 2
(Date:12/17/2014)...  Vermillion, Inc. (NASDAQ: VRML ), a ... the next step in its expanded strategy to rebuild ... the naming of current Chief Operating Officer, Valerie ... current Chairman of the Board and CEO James ... changes are effective January 1, 2015. "Jim ...
(Date:12/17/2014)... , Dec. 17, 2014 Tigercat Pharma, ... 2 study evaluating the investigational oral NK-1 receptor ... with severe, chronic itch who are unresponsive or ... including topical steroids and antihistamines. ... Visual Analog Scale (VAS) itch score from baseline, ...
(Date:12/15/2014)... & PETACH TIKVAH, Israel , ... BCLI ), a leading developer of adult ... wholly-owned subsidiary Brainstorm Cell Therapeutics Ltd. was awarded a ... Office of the Chief Scientist (OCS).  This ... receipt of grant support from the Office of the ...
(Date:12/15/2014)... 15, 2014  Origin Agritech Limited (NASDAQ GS: SEED) (" ... of crop seeds in China , today ... year 2014 ended September 30, 2014, before the market opens ... host a teleconference on January 8, 2015, at 8:00 a.m. ... to discuss the results. To participate in the call, please ...
Breaking Biology Technology:Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 2Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 3Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 4Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4BrainStorm Receives $1,100,000 for its 8th Annual Non-Dilutive Grant from Israel's Chief Scientist Office 2BrainStorm Receives $1,100,000 for its 8th Annual Non-Dilutive Grant from Israel's Chief Scientist Office 3Origin Agritech Limited to Announce Fiscal 2014 Annual Financial Results on January 8th, 2015 2Origin Agritech Limited to Announce Fiscal 2014 Annual Financial Results on January 8th, 2015 3
... PARIS, March 25 Hello, , ... and 2009 outlook has,been webcasted. The presentation is available ... http://www.thomson-webcast.net/uk/dispatching/?event_id=2ef87b3007af7a71 , a2e0f120f7f05e9c&portal_id=55a3fb63ef049550bc3b4d09baf7bf5e , ... it may be necessary to copy and paste,this hyperlink ...
... privately held biotechnology company focused on developing novel cancer ... viral vector, today announced that Frank Stonebanks, President and ... Venture Conference in Boston on Wednesday, April 1, 2009 ... , Cynvec, a privately held biotechnology company, is ...
... BMRN ) today announced that Jean-Jacques Bienaime, Chief ... the 4th Annual Citi Biotech Day in New York City ... may access a live audio webcast of the conference call ... . A replay of the call will be archived ...
Cached Biology Technology:BioMarin to Present at the 4th Annual Citi Biotech Day 2
Miniature FRENCH Pressure Cell with 3.7ml capacity; pressure up to 20,000 psi....
... CryoMed Freezers for IVF are designed for ... control, ease of setup and operation, and ... status are continuously displayed on the control ... data are printed by way of the ...
6 x Blend of rTth DNA Polymerase and Tli to provide optimized amounts of both 5-3 and 3-5 proofreading activity...
... Reverse Transcriptase is a recombinant Moloney ... MultiScribe Reverse Transcriptase is similar to ... its recommended usage. MuLV reverse transcriptase ... that uses single-stranded RNA as a ...
Biology Products: