Navigation Links
Salmonella bacteria use RNA to assess and adjust magnesium levels

Researchers at Washington University School of Medicine in St. Louis have added a gene in the bacterium Salmonella to the short list of genes regulated by a new mechanism known as the riboswitch.

The Salmonella riboswitch is the first to sense and respond to a metal ion, substantially expanding the types of molecules that riboswitches can detect to help cells assess and react to their environment.

First identified in 2002, riboswitches sense when a protein is needed and stop the creation of the protein if it isn't. That in itself isn't remarkable--scientists have been aware for decades of sensors in the cell that can cause molecules to bind to DNA to turn protein production on and off.

A riboswitch, however, doesn't rely on anything binding to DNA; instead, the switch is incorporated into messages for construction of proteins. These messages are protein-building instructions copied from DNA into strands of RNA. The riboswitch is a sensor within the RNA that can twist it into different configurations that block or facilitate the production of the protein encoded in the message.

Previously identified riboswitches respond to organic compounds such as nucleotides and sugars. The Salmonella riboswitch, reported in the April 7 issue of the journal Cell, responds to magnesium ions, key elements in the stability of cell membranes and reactants in an energy-making process that fuels most cells.

"Magnesium ions are essential to the stability of several different critical processes and structures in the cell, so there has to be a fairly intricate set of regulators to maintain consistent levels of it," says senior investigator Eduardo A. Groisman, Ph.D., professor of molecular microbiology. "To approach such a complex system, we study it in a simpler organism, the Salmonella bacterium."

Groisman and his colleagues uncovered the magnesium riboswitch while they were investigating the MgtA gene, which is controlled by the major
'"/>

Source:Washington University School of Medicine


Page: 1 2 3

Related biology news :

1. Salmonella caught red-handed
2. Salmonella survives better in stomach due to altered DNA
3. Anti-bacterial additive widespread in U.S. waterways
4. A bacterial genome reveals new targets to combat infectious disease
5. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
6. Scientists discover that host cell lipids facilitate bacterial movement
7. Family trees of ancient bacteria reveal evolutionary moves
8. Drug-resistant bacteria on poultry products differ by brand
9. Programmable cells: Engineer turns bacteria into living computers
10. NASA links nanobacteria to kidney stones and other diseases
11. Substance protects resilient staph bacteria
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Salmonella bacteria use RNA assess and adjust magnesium levels

(Date:5/11/2015)... Calif. , May 11, 2015  Synaptics ... of human interface solutions, today announced the appointment ... President and Chief Financial Officer, reporting to ... replaces Synaptics, current Chief Financial Officer, Kathleen ... 2014. Mr. Ali brings extensive ...
(Date:5/10/2015)... , May 11, 2015 Fingerprint ... sensors FPC1025 and FPC1155 from the distributor World Peace Industrial ... FPC,s distributors in Asia . Deliveries are ... will be used by smartphone manufacturers in China ... in the communicated revenue guidance of + 1 000 MSEK for ...
(Date:5/6/2015)... May 6, 2015 LifeBEAM, a developer of ... producer, announced today that they will expand their partnership ... first bio-sensing cycling helmet and the first joint project ... new colors in order to give cyclists more style ... addition, LifeBEAM and Lazer announced their plan to release ...
Breaking Biology News(10 mins):Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 235 Million 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3
... (BUSM) researchers have been awarded a Small Business Technology ... a newly designed fluorescent lamp that is capable of ... a professor of medicine, physiology and biophysics at BUSM ... Bone Health Clinic, and the Heliotherapy Light and Skin ...
... Texas, U.S.A. (Sept. 22, 2010) Candida albicans, a ... immune systems each year, grows more dangerous as it ... filaments. In a paper published this month, UT Health ... involved in this damaging growth. This finding ...
... Department of Defense will allow North Carolina State University ... Research to further test the effectiveness of molecules that ... The two-and-a-half-year project will show the efficacy of molecules ... John Cavanagh against different types of animal cells infected ...
Cached Biology News:NC State research grant will help military combat infections 2
(Date:5/29/2015)... Muncie, IN (PRWEB) May 29, 2015 ... scholarship funds to thirteen high school graduates from across ... Fund was created to award qualified AMA Youth Members ... in 1970, the AMA Scholarship Program has awarded nearly ... funds donated by model aviation organizations and individuals, AMA ...
(Date:5/29/2015)... London, UK (PRWEB) May 29, 2015 ... Co., Ltd. (Chem-Report ) signed a partnership agreement ... is now authorised to distribute and sell research ... Assistant Manager at Partners Department, commented upon the ... creating reports on key petroleum and chemical markets ...
(Date:5/29/2015)... 29, 2015 When a leading ... a request to design an industrial oven ... prescription medications being produced using a 3D-printing process, ... a robotic gantry, heat-saving windows, and internal actuators ... of 3D-printed pills to exact specifications. , To ...
(Date:5/29/2015)... 29, 2015  Caris Life Sciences ® , ... promise of precision medicine, today announced the presentation ... clinical utility of Caris Molecular Intelligence ® , ... helping to identify targeted treatment options for patients ... the studies, results of which are to be ...
Breaking Biology Technology:Academy of Model Aeronautics Awards $46,500 in Scholarships to College-Bound Model Aviation Pilots 2Market Publishers Ltd and Chem-Report Sign Partnership Agreement 2Market Publishers Ltd and Chem-Report Sign Partnership Agreement 3New industrial oven with “pill pushing” robotic gantry precisely removes excess moisture from 3D-printed pharmaceuticals 2Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 2Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 3Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 4Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 5Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 6
... Imago MADISON, Wis. Mass storage vendor ... Imago Scientific Instruments to meet the manufacturing challenges ... that Seagate has adopted Imago's LEAP Microscope to provide ... magnetic heads and media. , ,According to the company, ...
... RFID tag MADISON, Wis. A new RFID ... advance showing September 29 to attendees of the its ... is holding its seventh annual E-Business Best Practices ... , ,RFID, which involves tagging products or shipments with ...
... BROOKFIELD, Wis. Fiserv Imagesoft , a ... on Thursday that it has completed enhancement of its ... toward improving the security of image replacement documents (IRDs), ... an original check. , ,The new features of ExchangeGuard ...
Cached Biology Technology:E-business conference to give sneak peek into university RFID laboratory 2
Recommended fro Western blotting application...
... KLF15 is a Cys2-His2 zinc finger ... the liver, kidneys, heart, and skeletal muscle. ... antibody produced in rabbits immunized with a ... human KLF15 with an internal ID of ...
... Sac-Cel (Second Antibody Coated CELlulose) was ... Diagnostics of Dartford, Kent, one of the ... world. IDS acquired the product range in ... and clinical biochemists developing their own "in ...
Determin interaction of your protein with Echelons lipids...
Biology Products: