Navigation Links
Salk and Stanford teams join forces to reveal two paths of neurodegeneration

Wiring the developing brain is like creating a topiary garden. Shrubs don't automatically assume the shape of ornamental elephants, and neither do immature nerve cells immediately recognize the "right" target cell. Abundant foliage, either vegetal or neuronal, must first sprout and then be sculpted into an ordered structure.

Neurons extend fibers called axons to target cells in an exuberant manner--some branch to the "wrong" cells while others shoot past their target cells. Axon pieces that went astray degenerate, effectively being "pruned" back. Similarly, when axons are forcibly severed or seriously injured by disease in adults, they die and are removed by degeneration.

Scientists have speculated that the same molecular shears used to trim axon branches in injured adult axons also do so during normal developmental pruning. In a forthcoming issue of Neuron, teams at the Salk Institute for Biological Studies and Stanford University revise that notion and, in doing so, suggest how nerve function could be preserved after injury.

The collaboration began when senior co-authors Liqun Luo, PhD., a professor at Stanford University and Howard Hughes Medical Investigator, and Dennis D.M. O'Leary, a professor in the Salk Molecular Neurobiology Laboratory, co-wrote a review on neurodegeneration. Of O'Leary, Luo says, "When they asked me to write this review I found that half these things were started by Dennis." O'Leary adds, "We had a great time writing the review and it hatched the idea to combine our ideas."

They combined data collected by Luo's lab in fruitflies with experiments done in mice by O'Leary and co-lead author Todd McLaughlin, a postdoctoral fellow in the O'Leary lab.

When cut, axons in mice or fruitflies degenerate quickly. However, in so called Wlds mice, a naturally occurring mutant strain discovered years ago, the process is slowed, because the mice make a mutant protein--known as Wlds --that inhibits degeneration. '"/>

Source:Salk Institute


Page: 1 2 3

Related biology news :

1. Same mutation aided evolution in many fish species, Stanford study finds
2. First real-time view of developing neurons reveals surprises, say Stanford researchers
3. Stem cells from brain transformed to produce insulin at Stanford
4. Stanford gut check shows diversity of intestinal ecosystem
5. Young Blood Revives Aging Muscles, Stanford Researchers Find
6. Stem cell training program to make its Stanford debut
7. Gene therapy for muscular dystrophy fixes frail muscle cells in animal model, Stanford study finds
8. Sooner is better with cochlear implants, Stanford scientist shows
9. Learning to love bacteria: Stanford scientist highlights bugs benefits
10. For one Stanford doctor, the beat goes on during open-heart surgery
11. Stanford study of owls finds link in brain between sight and sound
Post Your Comments:
(Date:1/22/2015)... Infinisource has launched its new NXG series of time ... sets a higher standard for collecting attendance and labor data ... plug-and-play installation, touch screen interface and seamless connection to cloud-based ... collection solution for the small to mid-size employer. ...
(Date:12/22/2014)... 22, 2014  The 2014 Holiday Season may be the ... Intelligence reports that the long anticipated floodgates for consumer ... demand for smart phones, tablets, and wearable mobile devices ... 2.5 billion users with nearly 4.8 billion biometric devices ...
(Date:12/19/2014)...   LaunchKey , the first decentralized mobile authentication and ... Things era, today announced the close of $3 million ... by Metamorphic Ventures with participation from ENIAC Ventures, Crosslink ... LaunchKey has raised $4 million to date, and will ...
Breaking Biology News(10 mins):Infinisource's NXG series sets new time clock standard 2First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3
... game fish mistaken by scientists for a dog snapper ... of the Abrolhos region of the South Atlantic Ocean. ... of Lutjanus alexandrei, a new snapper species that belongs ... Conservation International (CI) and Kenyon Lindeman of Environmental Defense. ...
... Professor Lewis Rothberg of the University of Rochester Chemistry Department ... on a recent discovery by Huixiang Li, a research associate ... our health and make sure we're drinking clean water and ... used to help forensics labs identify criminals, test ponds and ...
... shed on proteorhodopsin, the light-sensitive protein found in many ... Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) and the ... the ability to respire oxygen is impaired, bacterium equipped ... out vital life processes. , "Our ...
Cached Biology News:New species of snapper discovered in Brazil 2Rapid, Low-Cost DNA Testing 2Rapid, Low-Cost DNA Testing 3Shedding new light on proteorhodopsin 2Shedding new light on proteorhodopsin 3
(Date:1/22/2015)... California (PRWEB) January 22, 2015 Eckert ... Accelerator Mass Spectrometry (AMS) services to the pharmaceutical and ... has joined the company in the position of Director ... years of broad and valuable experience in drug metabolism ...
(Date:1/22/2015)... Mass (PRWEB) January 21, 2015 Cambridge Semantics, ... Web technology, today announced that 2014 was a record-breaking year ... the capabilities of the Anzo Smart Data Platform and our ... and utilize insights from diverse data which led to record ...
(Date:1/22/2015)... MA (PRWEB) January 22, 2015 zFlo ... is pleased to announce an exciting product from a new ... motion analysis solutions over the past 15 years, with offerings ... Most recently, their 3D IMU system (inertial measurement unit), iSen, ...
(Date:1/22/2015)... BRUNSWICK , Nueva Jersey , 22 de ... Award for Biomedical Research abre hoy su llamada a ... personas cuya investigación científica ha hecho, o tiene el ... la salud humana. Las nominaciones se aceptarán hasta el ...
Breaking Biology Technology:Eckert & Ziegler Vitalea Science appoints Mark Seymour, PhD as Director of Science & Technology 2Eckert & Ziegler Vitalea Science appoints Mark Seymour, PhD as Director of Science & Technology 3Cambridge Semantics Announces Record Results for 2014 23D Motion Capture Just Got Easy 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4
... June 17 Berlin Heart Inc. today,announced it has ... FDA,to support the ongoing Investigational Device Exemption (IDE) study ... Almond of,the Children,s Hospital of Boston, and Bob Kroslowitz, ... serve as Co-Principal,Investigators for the grant project "Safety and ...
... , ... More Seed Options in the Marketplace. , ... Des Moines, Iowa, and Atlanta, Ind. (Vocus) June 17, 2009 –- Pioneer ... have entered into research and distribution agreements to bring additional corn and soybean products to ...
... N.C., June 17 Campbell Alliance, the leading management ... today announced that it has appointed industry veterans Jon ... Both gentlemen will work directly with John Campbell, ... areas to advise the firm,s emerging and midsize client ...
Cached Biology Technology:Berlin Heart Inc. Receives FDA Orphan Product Development Grant 2Pioneer Hi-Bred and Beck's Hybrids Enter into Research and Distribution Agreements 2Pioneer Hi-Bred and Beck's Hybrids Enter into Research and Distribution Agreements 3Campbell Alliance Adds Industry Veterans Jon W. McGarity and David Lilley as Executive Vice Presidents 2Campbell Alliance Adds Industry Veterans Jon W. McGarity and David Lilley as Executive Vice Presidents 3Campbell Alliance Adds Industry Veterans Jon W. McGarity and David Lilley as Executive Vice Presidents 4
... by N.C. Price (1996) • ... on protein chemistry and the ... proteins. Data on the following ... size determination, amino acid analysis ...
... B.S. Dunbar (1994) • This book ... and methods for preparing samples for ... as radiometric and bioluminescence-enhanced detection systems ... are, the detection and characterization of ...
See product name for description....
RAT ANTI MOUSE TCR V BETA 7:RPE Immunogen: T-cell lymphoma TK1...
Biology Products: