Navigation Links
Role of protein in immune response may aid HIV research

A family of proteins that serve as the body's first line of defense against bacterial infections may provide a lifeline for individuals with compromised immune systems, according to researchers at the Indiana University School of Medicine ?Northwest.

In the July 28 issue of the Journal of Biological Chemistry, Roman Dziarski, Ph.D., and Dipika Gupta, Ph.D., propose that the proteins might be used to develop medications that could boost the body's impaired day-to-day response to bacteria in HIV/AIDS patients and others with compromised immune responses. The scientists announced discovery of the protein called PGLYRP ? peptidoglycan recognition proteins ? earlier this year.

Patients, such as those with HIV/AIDS, are susceptible to bacterial infections that are easily averted by people with healthy immune systems but are life-threatening to people with impaired systems.

Drs. Dziarski and Gupta, in their latest report, revealed many parts of the body produce these proteins, which fight disease-causing bacteria. These proteins appear to be the front line in defending the body from infection, mounting a defense long before the body's main immune system responds.

The IU School of Medicine ?Northwest scientists report that various organs mount different defensive responses with PGLYRP when exposed to bacteria. The skin produces these proteins only when exposed to virulent or high numbers of bacteria.

In contrast, the liver, whose function is to continuously monitor the blood and fight acute infection, produces PGLYRP constantly. The researchers suggest that the liver's constant protein production may help fulfill the organ's preventative role as a blood filter.


'"/>

Source:Indiana University


Page: 1

Related biology news :

1. New, automated tool successfully classifies and relates proteins in unprecedented way
2. New binding target for oncogenic viral protein
3. Controversial drug shown to act on brain protein to cut alcohol use
4. Timing is everything: First step in protein building revealed
5. UWs Rosetta software to unlock secrets of many human proteins
6. Researchers find how protein allows insects to detect and respond to pheromones
7. Signaling protein builds bigger, better bones in mice
8. Ancient olfaction protein is shared by many bugs, offering new pest control target
9. Automatic extraction of gene/protein biological functions from biomedical text
10. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/20/2016)... Jan. 20, 2016   MedNet Solutions , an ... spectrum of clinical research, is pleased to announce the ... achievements are the result of the company,s laser focus ... eClinical , it,s comprehensive, easy-to-use and highly affordable ... --> Key MedNet growth achievements in 2015 include: ...
(Date:1/18/2016)... JOSE, Calif. , Jan. 18, 2016 /PRNewswire/ ... security software that simplifies the use and access ... technology and go-to-market partnership with American Cyber.  ... Cyber brings extensive experience leading transformational C4ISR and ... implementing and integrating the latest proven technology solutions," ...
(Date:1/13/2016)... --> --> ... report titled - Biometric Sensors Market - Global Industry Analysis, ... to the report, the global biometric sensors market was valued at ... US$1,625.8 mn by 2023, expanding at a CAGR of ... the biometric sensors market is expected to reach 1,799.6 ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... ... February 11, 2016 , ... Reichert ... years, continues today to pursue the highest level of accuracy and quality with ... AR9 Refractometer and the AR5 Refractometer. Accurate, reliable and tough enough for ...
(Date:2/10/2016)...  The Maryland House of Delegates and House Speaker ... of Maryland School of Medicine Dean E. Albert ... Medical System President and CEO Robert Chrencik , ... honor given to the public by the leader of ... and Mr. Chrencik for their contributions to our ...
(Date:2/10/2016)... 10, 2016  Allergan plc (NYSE: AGN ) ... Brent Saunders , Allergan,s CEO and President, will be ... session at the RBC Capital Markets Healthcare Conference on ... The New York Palace Hotel in New ... live and can be accessed on Allergan,s Investor Relations ...
(Date:2/10/2016)... , ... February 10, 2016 , ... ... to their comprehensive training and support program, Sonalinkā„¢ remote monitoring. The inaugural launch ... performed on Friday, February 5th, connecting Dr. Samuel Peretsman to a HIFU technical ...
Breaking Biology Technology: