Navigation Links
Role of protein in immune response may aid HIV research

A family of proteins that serve as the body's first line of defense against bacterial infections may provide a lifeline for individuals with compromised immune systems, according to researchers at the Indiana University School of Medicine ?Northwest.

In the July 28 issue of the Journal of Biological Chemistry, Roman Dziarski, Ph.D., and Dipika Gupta, Ph.D., propose that the proteins might be used to develop medications that could boost the body's impaired day-to-day response to bacteria in HIV/AIDS patients and others with compromised immune responses. The scientists announced discovery of the protein called PGLYRP ? peptidoglycan recognition proteins ? earlier this year.

Patients, such as those with HIV/AIDS, are susceptible to bacterial infections that are easily averted by people with healthy immune systems but are life-threatening to people with impaired systems.

Drs. Dziarski and Gupta, in their latest report, revealed many parts of the body produce these proteins, which fight disease-causing bacteria. These proteins appear to be the front line in defending the body from infection, mounting a defense long before the body's main immune system responds.

The IU School of Medicine ?Northwest scientists report that various organs mount different defensive responses with PGLYRP when exposed to bacteria. The skin produces these proteins only when exposed to virulent or high numbers of bacteria.

In contrast, the liver, whose function is to continuously monitor the blood and fight acute infection, produces PGLYRP constantly. The researchers suggest that the liver's constant protein production may help fulfill the organ's preventative role as a blood filter.


'"/>

Source:Indiana University


Page: 1

Related biology news :

1. New, automated tool successfully classifies and relates proteins in unprecedented way
2. New binding target for oncogenic viral protein
3. Controversial drug shown to act on brain protein to cut alcohol use
4. Timing is everything: First step in protein building revealed
5. UWs Rosetta software to unlock secrets of many human proteins
6. Researchers find how protein allows insects to detect and respond to pheromones
7. Signaling protein builds bigger, better bones in mice
8. Ancient olfaction protein is shared by many bugs, offering new pest control target
9. Automatic extraction of gene/protein biological functions from biomedical text
10. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/9/2016)... ISTANBUL , June 9, 2016  Perkotek an innovation leader in attendance control ... to seamlessly log work hours, for employers to make sure the right employees are ... Logo - http://photos.prnewswire.com/prnh/20160609/377486LOGO ... ... ...
(Date:6/2/2016)... 2016 The Department of Transport Management ... 44 million US Dollar project, for the , ... Personalization, Enrolment, and IT Infrastructure , to ... and implementation of Identity Management Solutions. Numerous renowned international vendors ... Decatur was selected for the most compliant and ...
(Date:5/24/2016)... 2016 Ampronix facilitates superior patient care by providing unparalleled technology to leaders ... is the latest premium product recently added to the range of products distributed by ... ... ... LCD Medical Display- Ampronix News ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... June 23, 2016 ... 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 Published recently ... peer-reviewed journal from touchONCOLOGY, Andrew D Zelenetz ... of cancer care is placing an increasing burden ... expensive biologic therapies. With the patents on many ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... line of intelligent tools designed, tuned and optimized exclusively for Okuma CNC machining ... Chicago. The result of a collaboration among several companies with expertise in toolholding, ...
(Date:6/22/2016)... DUBLIN , June 22, 2016 Research ... and Global Markets" report to their offering. ... $39.4 billion in 2014 from $29.3 billion in 2013. The market ... (CAGR) of 13.8% from 2015 to 2020, increasing from $50.6 billion ... and projected product forecasts during the forecast period (2015 to 2020) ...
(Date:6/22/2016)... SAN DIEGO , June 22, 2016   ... the first pluripotent stem cell-derived islet replacement therapy for ... two presentations at ISSCR 2016 Annual Meeting.  ISSCR 2016, ... 22nd to 25th at Moscone West in San Francisco.  ... Details of the presentations are as follows:Event: , Focus ...
Breaking Biology Technology: