Navigation Links
Role of noise in neurons

Addressing a current issue in neuroscience, Aldo Faisal and Simon Laughlin from Cambridge University investigate the reliability of thin axons for transmitting information. They show that noise effects in ion channels in the brain are much larger than previously assumed ?meaning the fidelity of transmission is compromised.

Neurons in the cerebral cortex of the brain can have a wiring density of up to 4km per mm3 by using incredibly thin axons as wires, with an average diameter of 0.3 micrometers (1ìm is one millionth of a meter). Although, as in computer chips, this miniaturization economizes on space and energy, it increases the noise introduced by thermodynamic fluctuations in a neuron's voltage-gated ion channels. Axons use action potential (AP) to transmit information fast and reliably to synapses, but the reliability of transmissions down fibers of less than 0.5 ìm in diameter was unknown until this paper.

Using detailed models of rodent and squid axons and stochastic simulations, the authors performed experiments, now published in PLoS Computational Biology, which took several months to simulate a few milliseconds of real time in the brain. They show how conduction along such thin axons is affected by the probabilistic nature of voltage-gated ion channels (channel noise). Channel noise destroys information in the AP, and they conclude that these effects are much larger than previously supposed and therefore must be taken into account in any future studies of neural coding and the reliability of synaptic transmission.


'"/>

Source:Public Library of Science


Page: 1

Related biology news :

1. Elephants imitate truck noises, other animals
2. Researchers quantify more noise in gene expression
3. Phenotype is influenced by nature, nurture and noise
4. New dyslexia theory blames noise
5. Mysterious neural noise actually primes brain for peak performance
6. Cells use noise to make cell-fate decisions
7. Dinosaur hearing, listening to muscle noise, quieter cubicles
8. Eating, body weight regulated by specific neurons
9. Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons
10. Nanowire arrays can detect signals along individual neurons
11. Parkinsons mutation stunts neurons
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2016)... First quarter 2016:   , Revenues amounted ... quarter of 2015 The gross margin was 49% (27) ... the operating margin was 40% (-13) Earnings per share ... operations was SEK 249.9 M (21.2) , Outlook   ... M. The operating margin for 2016 is estimated to ...
(Date:4/19/2016)... April 20, 2016 The new ... a compact web-based "all-in-one" system solution for all door ... reader or the door interface with integration authorization management ... control systems. The minimal dimensions of the access control ... the building installations offer considerable freedom of design with ...
(Date:4/14/2016)... 14, 2016 BioCatch ™, ... today announced the appointment of Eyal Goldwerger ... Goldwerger,s leadership appointment comes at a time ... the deployment of its platform at several of the ... which discerns unique cognitive and physiological factors, is a ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 2016 Houston Methodist Willowbrook Hospital has ... Association to serve as their official health care ... Willowbrook will provide sponsorship support, athletic training services, ... coaches, volunteers, athletes and families. "We ... Association and to bring Houston Methodist quality services ...
(Date:6/23/2016)... ... , ... Supplyframe, the Industry Network for electronics hardware design ... Located in Pasadena, Calif., the Design Lab’s mission is to bring together inventors ... and brought to market. , The Design Lab is Supplyframe’s physical representation of ...
(Date:6/23/2016)... , June 23, 2016 ... Hematology Review, 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 ... , the peer-reviewed journal from touchONCOLOGY, Andrew ... escalating cost of cancer care is placing an ... result of expensive biologic therapies. With the patents ...
(Date:6/23/2016)... , June 22, 2016  Amgen (NASDAQ: ... of the QB3@953 life sciences incubator to ... health. The shared laboratory space at QB3@953 was created ... a key obstacle for many early stage organizations - ... of the sponsorship, Amgen launched two "Amgen Golden Ticket" ...
Breaking Biology Technology: