Navigation Links
Role of noise in neurons

Addressing a current issue in neuroscience, Aldo Faisal and Simon Laughlin from Cambridge University investigate the reliability of thin axons for transmitting information. They show that noise effects in ion channels in the brain are much larger than previously assumed ?meaning the fidelity of transmission is compromised.

Neurons in the cerebral cortex of the brain can have a wiring density of up to 4km per mm3 by using incredibly thin axons as wires, with an average diameter of 0.3 micrometers (1ìm is one millionth of a meter). Although, as in computer chips, this miniaturization economizes on space and energy, it increases the noise introduced by thermodynamic fluctuations in a neuron's voltage-gated ion channels. Axons use action potential (AP) to transmit information fast and reliably to synapses, but the reliability of transmissions down fibers of less than 0.5 ìm in diameter was unknown until this paper.

Using detailed models of rodent and squid axons and stochastic simulations, the authors performed experiments, now published in PLoS Computational Biology, which took several months to simulate a few milliseconds of real time in the brain. They show how conduction along such thin axons is affected by the probabilistic nature of voltage-gated ion channels (channel noise). Channel noise destroys information in the AP, and they conclude that these effects are much larger than previously supposed and therefore must be taken into account in any future studies of neural coding and the reliability of synaptic transmission.


Source:Public Library of Science

Page: 1

Related biology news :

1. Elephants imitate truck noises, other animals
2. Researchers quantify more noise in gene expression
3. Phenotype is influenced by nature, nurture and noise
4. New dyslexia theory blames noise
5. Mysterious neural noise actually primes brain for peak performance
6. Cells use noise to make cell-fate decisions
7. Dinosaur hearing, listening to muscle noise, quieter cubicles
8. Eating, body weight regulated by specific neurons
9. Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons
10. Nanowire arrays can detect signals along individual neurons
11. Parkinsons mutation stunts neurons
Post Your Comments:

(Date:11/16/2015)... , Nov 16, 2015  Synaptics Inc. ... human interface solutions, today announced expansion of its ... ™ touch controller and display driver integration ... of smartphones. These new TDDI products add to ... (HD resolution), TD4302 (WQHD resolution), and TD4322 (FHD ...
(Date:11/12/2015)... 12, 2015  Arxspan has entered into an ... Harvard for use of its ArxLab cloud-based suite ... The partnership will support the institute,s efforts to ... research information internally and with external collaborators. The ... managing the Institute,s electronic laboratory notebook, compound and ...
(Date:11/11/2015)... MedNet Solutions , an innovative SaaS-based eClinical technology company that ... announce that it will be a Sponsor of the ... held November 17-19 in Hamburg , Germany.  ... iMedNet , MedNet,s easy-to-use, proven and affordable eClinical ... able to deliver time and cost savings of up to ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... --> ... 2020 report analyzes that automating biobanking workflow will ... long-term samples, minimizing manual errors, improving the workflow ... errors such as mislabeling or inaccurate sample barcoding ... a vital role in blood fractionation, DNA extraction, ...
(Date:11/25/2015)... , Nov. 25, 2015  Neurocrine Biosciences, Inc. ... Gorman , President and CEO of Neurocrine Biosciences, will ... Conference in New York . ... visit the website approximately 5 minutes prior to the ... replay of the presentation will be available on the ...
(Date:11/25/2015)... (PRWEB) , ... November 25, 2015 , ... ... company uBiome, were featured on AngelList early in their initial angel funding process. ... AngelList syndicate for individuals looking to make early stage investments in the microbiome ...
(Date:11/24/2015)... /CNW/ - iCo Therapeutics ("iCo" or "the Company") (TSX-V: ... the quarter ended September 30, 2015. Amounts, unless ... presented under International Financial Reporting Standards ("IFRS"). ... Andrew Rae , President & CEO of ... only value enriching for this clinical program, but ...
Breaking Biology Technology: