Navigation Links
Rice scientists make first nanoscale pH meter

Using unique nanoparticles that convert laser light into useful information, Rice University scientists have created the world's first nano-sized pH meter.

The discovery, which appears online this week in the journal Nano Letters, presents biologists with the first potential means of measuring accurate pH changes over a wide pH range in real-time inside living tissue and cells.

"Almost every biologist I speak with comes up with one or two things they'd like to measure with this," said lead researcher Naomi Halas, the Stanley C. Moore Professor of Electrical and Computer Engineering, professor of chemistry and director of Rice's Laboratory for Nanophotonics (LANP).

For example, pH may be useful in determining whether or not some cancer tumors are malignant. With current methods, a piece of the tumor would need to be physically removed via biopsy ?a painful and invasive procedure ?and visually evaluated under a microscope. Halas said LANP's new nano-pH meter could be used instead as an "optical biopsy" to measure the pH inside the tumor with nothing more invasive than an injection.

Halas's LANP team created the pH sensor using nanoshells, optically tuned nanoparticles invented by Halas. Each nanoshell contains a tiny core of non-conducting silica that's covered by a thin shell of metal, usually gold. Many times smaller than living cells, nanoshells can be produced with great precision and the metal shells can be tuned to absorb or scatter specific wavelengths of light.

To form the pH sensor, Halas' team coated the nanoshells with pH-sensitive molecules called paramercaptobenzoic acid, or pMBA. When placed in solutions of varying acidity and illuminated, the nanoshell-molecule device provides small but easily detectable changes in the properties of the scattered light that, when "decoded," can be used to determine the pH of the nanodevice's local environment to remarkably high accuracy. Inspired by techniques normally applied to i mage recognition, the team formulated an efficient statistical learning procedure to produce the device output, achieving an average accuracy of 0.1 pH units.

The term "pH" was coined by the Danish chemist Søren Sørensen in 1909 as a convenient way of expressing a solution's acidity. pH ranges from one ?the most acidic ?to 14 ?the most alkaline.


'"/>

Source:Rice University


Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
3. UAB scientists discover the origin of a mysterious physical force
4. Fox Chase Cancer Center scientists identify immune-system mutation
5. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
6. U-M scientists find genes that control growth of common skin cancer
7. UCLA scientists transform HIV into cancer-seeking missile
8. RNA project to create language for scientists worldwide
9. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
10. To control germs, scientists deploy tiny agents provocateurs
11. Leprosy microbes lead scientists to immune discovery
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/2/2016)... http://www.researchandmarkets.com/research/wzwqtz/global_biometrics ... "Global Biometrics Market in Hospitality Sector 2016-2020" ... , , Global biometrics market in the ... of around 27%   --> ... addition of the  "Global Biometrics Market in ...
(Date:3/1/2016)... , March 1, 2016 ... the addition of the  "Global Biometric ...  report to their offering. --> ... addition of the  "Global Biometric Access ... to their offering. --> ...
(Date:3/1/2016)... NEW YORK and SAN FRANCISCO ... announced today between HYPR Corp. and BitGo, Inc. extends ... assets, cryptocurrency, identities and private keys. ... secures over $1 billion per month in digital assets ... a staggering figure for any startup. HYPR enables enterprises ...
Breaking Biology News(10 mins):
(Date:5/3/2016)... ... May 03, 2016 , ... Morf Media Inc ... training platform on mobile devices, today released a new interactive Food and ... Devices. The course is essential for owners or operators of places of business ...
(Date:5/3/2016)... ... May 03, 2016 , ... Wearable Tech ... driven conferences, will take place on June 7-8, 2016, at the New York Academy ... on incorporating technology -- including AR/VR, machine learning, apps, robotics and AI -- throughout ...
(Date:5/2/2016)... , May 2, 2016 Q ... its technology partner Mannin Research Inc. will be attending ... which takes place from May 1-5, 2016 in ... be meeting with its vendors and research partners. The ... development goals and other collaborative opportunities for the MAN-01 ...
(Date:4/29/2016)... ... April 29, 2016 , ... Proove ... excited to announce the launch of the Proove Health Foundation . The ... education to promote the use of personalized medicine for tackling the nation’s most-pressing ...
Breaking Biology Technology: