Navigation Links
Rewind, please: Nature paper shows that cell division is reversible

Gary J. Gorbsky, Ph.D., a scientist with the Oklahoma Medical Research Foundation, has found a way to reverse the process of cell division.

The discovery could have important implications for the treatment of cancer, birth defects and numerous other diseases and disorders. Gorbsky's findings appear in the April 13 issue of the journal Nature.

"No one has gotten the cell cycle to go backwards before now," said Gorbsky, who holds the W.H. and Betty Phelps Chair in Developmental Biology at OMRF. "This shows that certain events in the cell cycle that have long been assumed irreversible may, in fact, be reversible."

Cell division occurs millions of times each day in the human body and is essential to life itself. In the lab, Gorbsky and his OMRF colleagues were able to control the protein responsible for the division process, interrupt and reverse the event, sending duplicate chromosomes back to the center of the original cell, an event once thought impossible.

"Our studies indicate that the factors pointing cells toward division can be turned and even reversed," Gorbsky said. "If we wait too long, however, it doesn't work, so we know that there are multiple regulators in the cell division cycle. Now we will begin to study the triggers that set these events in motion."

The findings may prove important to controlling the development and metastasis of certain cancers. It also holds promise for the prevention and treatment of birth defects and a wide variety of other conditions.

"Dr. Gorbsky's results provide elegant proof that the cell cycle must be precisely controlled," said Dr. Rodger McEver, OMRF vice president of research. "Now he and his lab can work toward developing innovative methods to probe and better understand the complex process of cell division."

Gorbsky heads the Molecular, Cell and Developmental Biology Research Program at OMRF and holds both an M.A. and a Ph.D. in biology from Princeton University. He is also adjunct professor of Cell Biology at the University of Oklahoma Health Sciences Center and a member of the OU Cancer Institute. His research focuses on mitosis and cytokinesis, the processes involved in cell division, and he has earned international recognition for his work in the area of chromosomal movement and cell cycle control.


'"/>

Source:Oklahoma Medical Research Foundation


Related biology news :

1. Nature provides inspiration for important new adhesive
2. First production of human monoclonal antibodies in chicken eggs published in Nature Biotechnology
3. Origen publishes in Nature a robust and versatile method for creating transgenic chickens
4. Natures process for nitrogen fixation caught in action
5. UCLA paper examines how one disease may prevent another
6. Recycled paper and compost could both be key tools to control plant disease
7. Developing uses for sugar-cane bagasse: Biotechnology applied to the paper industry
8. McBride shows DNA detective work with paper-eating bacteria that glide
9. Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
10. “Nano-scissors?laser shows precise surgical capability
11. Clam embryo study shows pollutant mixture adversely affects nerve cell development
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... Florida , April 11, 2017 ... a security technology company, announces the appointment of independent Directors ... Bendheim to its Board of Directors, furthering the company,s ... ... of NXT-ID, we look forward to their guidance and benefiting ...
(Date:4/5/2017)...  The Allen Institute for Cell Science today announces ... portal and dynamic digital window into the human cell. ... application of deep learning to create predictive models of ... a growing suite of powerful tools. The Allen Cell ... publicly available resources created and shared by the Allen ...
(Date:4/5/2017)... -- KEY FINDINGS The global market for ... of 25.76% during the forecast period of 2017-2025. The ... the growth of the stem cell market. ... INSIGHTS The global stem cell market is segmented on ... stem cell market of the product is segmented into ...
Breaking Biology News(10 mins):
(Date:10/7/2017)... ... October 06, 2017 , ... ... genomic technologies, launched its ProxiMeta™ Hi-C metagenome deconvolution product, featuring the first ... accompanying cloud-based bioinformatics software to perform Hi-C metagenome deconvolution using their own ...
(Date:10/6/2017)... ... 06, 2017 , ... The HealthTech Venture Network (HTVN) is ... fourth annual Conference where founders, investors, innovative practitioners and collaborators are invited to ... showcasing early stage digital health and med tech companies. , This day-long event ...
(Date:10/5/2017)... ... October 05, 2017 , ... LabRoots , the leading ... around the world, is giving back to cancer research with a month-long promotion supporting ... Now through October 31, shoppers can use promo code PinkRibbon to get 10 percent ...
(Date:10/5/2017)... ... October 05, 2017 , ... NIH has ... its Nanobind DNA/RNA extraction technology . Nanobind is a novel magnetic disk ... and that can be used for a wide variety of sample preparation applications. ...
Breaking Biology Technology: