Navigation Links
Retroviral resistance gene found

Dr. Stephen Goff and colleagues have identified a novel retroviral resistance gene, called FEZ1, that can mediate a potent resistance to murine leukemia virus, as well as HIV-1, in cell culture. The researchers found that the high level of FEZ1 expression in a specific laboratory rat cell line caused a significant block to retroviral infection ?retroviruses were able to enter the host cells and synthesize the viral DNA, but were excluded from entering the host cell nucleus.

"We suspect that the overexpression of FEZ1 interferes with intracellular trafficking of the viral preintegration complex and traps the viral DNA in the cytoplasm. We hope that learning more about this transport machinery might reveal a new target for antiviral drugs in the treatment of HIV-1 disease."


'"/>

Source:Cold Spring Harbor Laboratory


Page: 1

Related biology news :

1. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
2. Researchers make gains in understanding antibiotic resistance
3. MUHC scientists describe genetic resistance to rampant virus
4. New polysaccharide may help combat multidrug resistance in cancer
5. New book explains antibiotic resistance for a broad audience
6. Insects develop resistance to engineered crops
7. Drug resistance testing in treatment-naive HIV patients is cost-effective
8. Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance
9. Gaining ground in the race against antibiotic resistance
10. Genes linked to treatment resistance in children with leukemia
11. Einstein researchers identify new way that bacteria develop resistance to antibiotics
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... , April 11, 2017 Crossmatch®, ... secure authentication solutions, today announced that it has ... Advanced Research Projects Activity (IARPA) to develop next-generation ... program. "Innovation has been a driving ... Thor program will allow us to innovate and ...
(Date:4/5/2017)... , April 5, 2017  The Allen Institute for ... Cell Explorer: a one-of-a-kind portal and dynamic digital window ... imaging data, the first application of deep learning to ... stem cell lines and a growing suite of powerful ... for these and future publicly available resources created and ...
(Date:3/30/2017)... 30, 2017  On April 6-7, 2017, Sequencing.com will ... hackathon at Microsoft,s headquarters in ... focus on developing health and wellness apps that provide ... the Genome is the first hackathon for personal ... largest companies in the genomics, tech and health industries ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... ... May 23, 2017 , ... Bacterial biofilms, surface adherent communities ... cause diverse pathologies ranging from food poisoning and catheter infections to gum disease and ... the tens of billions of dollars per year, there is currently a paucity of ...
(Date:5/23/2017)... (PRWEB) , ... May 23, 2017 , ... ... machine manufacturers to re-engineer their control technology again and again. METTLER TOLEDO has ... for machine manufacturers. The videos illustrate how integration of the ACT350 into Siemens ...
(Date:5/22/2017)... ... May 22, 2017 , ... Baltimore biotech firm, PathSensors, announced ... community in developing and issuing recommendations to grow Maryland's biohealth industry and position ... 2023. , The recommendations are contained in a report from ...
(Date:5/21/2017)... ... 19, 2017 , ... Ovation Fertility scientists’ work is being ... Bioanalysts (AAB) and the College of Reproductive Biology (CRB) today and Saturday (May ... excellence in clinical laboratory services and regulations. , “We are pleased to ...
Breaking Biology Technology: