Navigation Links
Resveratrol prolongs lifespan and delays onset of aging-related traits in a short-lived vertebrate

By studying a particularly short-lived fish species, researchers have been able to show that a natural compound previously shown to extend lifespan in non-vertebrate organisms can also do so in at least one vertebrate species. The findings, reported by Alessandro Cellerino of the Scuola Normale Superiore, Pisa, and colleagues, support the potential utility of the compound in human aging research.

The development of drugs able to retard the onset of aging-related diseases and improve quality of life in the elderly is a growing focus of aging research and public health in modern society. But the successful development of drugs aimed at aging-related diseases needs to face the challenge posed by the lifespan of the available animal models--mammalian models for aging are relatively long-lived and aren't as easily studied as shorter-lived species.

Resveratrol is an organic compound naturally present in grapes--and particularly enriched in red wine--and was previously shown to prolong lifespan in non-vertebrate model organisms such as yeast, the worm C. elegans, and the fruit fly Drosophila. However, until now, life-long pharmacological trials were performed in the worm or fly model organisms because of their very small size, very short natural lifespan, and affordable cultivation costs. Laboratory mice, on the other hand, live more than two years and are relatively expensive to maintain, making large-scale, life-long pharmacological trials in mice unaffordable.

Recently, a small fish species with a captive lifespan of only three months was described by Cellerino and colleagues. In the new work, the researchers used this short-lived fish to test the effects of resveratrol on aging-related physiological decay. The researchers added resveratrol to daily fish food and found that this treatment increased longevity and also retarded the onset of aging-related decays in memory and muscular performance.

Resveratrol appears to be the first molecul e to consistently cause life extension across very different animal groups such as worms, insects, and fish, and it could become the starting molecule for the design drugs for the prevention of human aging-related diseases.


'"/>

Source:Cell Press


Related biology news :

1. Researchers extend mouse lifespan by protecting against free radicals
2. New lifespan extension genes found
3. MicroRNA gene that regulates lifespan found by Yale scientists
4. Fish evolve a longer lifespan by evolving a longer reproductive period, researchers find
5. New research says winning a Nobel Prize adds nearly 2 years to your lifespan
6. Researchers find link between food odors and lifespan in fruit flies
7. Sexual reproduction delays aging in a mammalian species
8. Matrilin-3 gene discovered to prevent onset of osteoarthritis
9. Gene therapy prevents the onset of diabetic symptoms in mice
10. Temperament linked to onset of cancer and early death in female rats
11. Canadian study shows bilingualism has protective effect in delaying onset of dementia by four years
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/8/2017)... Mass., Feb. 7, 2017  Aware, Inc. (NASDAQ: ... today reported financial results for its quarter and year ended ... quarter of 2016 was $3.9 million compared to $6.9 million ... fourth quarter of 2016 was $0.6 million compared to $2.6 ... the fourth quarter of 2016 was $0.5 million, or $0.02 ...
(Date:2/8/2017)... , Feb. 7, 2017 Report Highlights ... by 2021 from $8.3 billion in 2016 at a ... to 2021. Report Includes - An overview of ... market trends, with data from 2015 and 2016, and ... - Segmentation of the market on the basis of ...
(Date:2/7/2017)... York , February 7, 2017 ... ID Global Solutions Corporation [OTC: IDGS], ("Ipsidy" or the ... and electronic transaction processing services, is pleased to announce ... the Company. Effective January 31, 2017, ... Board of Directors, CEO and President.  An experienced payment ...
Breaking Biology News(10 mins):
(Date:2/24/2017)... , Feb. 24, 2017  Aethlon Medical, Inc. (Nasdaq: ... authored by its Chairman and CEO, Jim Joyce ... Munich Security Conference last Saturday, Bill Gates ... kill more people than nuclear weapons. Mr. Gates expressed ... U.K. intelligence agencies, that scientific terrorists have access to ...
(Date:2/24/2017)... ... February 24, 2017 , ... FireflySci, Inc is an explosive small business ... had the goal of bringing their powerful cuvette and spectrophotometer calibration to ... that FireflySci is going on as they add yet another mark on the global ...
(Date:2/23/2017)... YORK , Feb. 23, 2017 ... digital health company, and Digital Noema Telehealth ... remote patient monitoring, announce they are partnering to ... DN Telehealth maximizes collaboration compatibility for its ... beyond a physical clinical setting to include fully ...
(Date:2/23/2017)... 2017  MIODx announced today that it has ... technologies from the University of California, San Francisco ... monitor a patient for response to immune checkpoint ... second license extends the technology with a method ... have an immune-related adverse event (IRAE) from their ...
Breaking Biology Technology: