Navigation Links
Resveratrol prolongs lifespan and delays onset of aging-related traits in a short-lived vertebrate

By studying a particularly short-lived fish species, researchers have been able to show that a natural compound previously shown to extend lifespan in non-vertebrate organisms can also do so in at least one vertebrate species. The findings, reported by Alessandro Cellerino of the Scuola Normale Superiore, Pisa, and colleagues, support the potential utility of the compound in human aging research.

The development of drugs able to retard the onset of aging-related diseases and improve quality of life in the elderly is a growing focus of aging research and public health in modern society. But the successful development of drugs aimed at aging-related diseases needs to face the challenge posed by the lifespan of the available animal models--mammalian models for aging are relatively long-lived and aren't as easily studied as shorter-lived species.

Resveratrol is an organic compound naturally present in grapes--and particularly enriched in red wine--and was previously shown to prolong lifespan in non-vertebrate model organisms such as yeast, the worm C. elegans, and the fruit fly Drosophila. However, until now, life-long pharmacological trials were performed in the worm or fly model organisms because of their very small size, very short natural lifespan, and affordable cultivation costs. Laboratory mice, on the other hand, live more than two years and are relatively expensive to maintain, making large-scale, life-long pharmacological trials in mice unaffordable.

Recently, a small fish species with a captive lifespan of only three months was described by Cellerino and colleagues. In the new work, the researchers used this short-lived fish to test the effects of resveratrol on aging-related physiological decay. The researchers added resveratrol to daily fish food and found that this treatment increased longevity and also retarded the onset of aging-related decays in memory and muscular performance.

Resveratrol appears to be the first molecul e to consistently cause life extension across very different animal groups such as worms, insects, and fish, and it could become the starting molecule for the design drugs for the prevention of human aging-related diseases.


'"/>

Source:Cell Press


Related biology news :

1. Researchers extend mouse lifespan by protecting against free radicals
2. New lifespan extension genes found
3. MicroRNA gene that regulates lifespan found by Yale scientists
4. Fish evolve a longer lifespan by evolving a longer reproductive period, researchers find
5. New research says winning a Nobel Prize adds nearly 2 years to your lifespan
6. Researchers find link between food odors and lifespan in fruit flies
7. Sexual reproduction delays aging in a mammalian species
8. Matrilin-3 gene discovered to prevent onset of osteoarthritis
9. Gene therapy prevents the onset of diabetic symptoms in mice
10. Temperament linked to onset of cancer and early death in female rats
11. Canadian study shows bilingualism has protective effect in delaying onset of dementia by four years
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/22/2016)... , June 22, 2016  The American College of Medical ... Show Executive Magazine as one of the fastest-growing trade ... 25-27 at the Bellagio in Las Vegas ... highest percentage of growth in each of the following categories: ... companies and number of attendees. The 2015 ACMG Annual Meeting ...
(Date:6/20/2016)... 20, 2016 Securus Technologies, a leading ... for public safety, investigation, corrections and monitoring announced ... it has secured the final acceptance by all ... Managed Access Systems (MAS) installed. Furthermore, Securus will ... be installed by October, 2016. MAS distinguishes between ...
(Date:6/9/2016)... Finland , June 9, 2016 ... National Police deploy Teleste,s video security solution to ensure the ... France during the major tournament ... data communications systems and services, announced today that its video ... Prefecture to back up public safety across the ...
Breaking Biology News(10 mins):
(Date:12/5/2016)... 2016  Renova™ Therapeutics, a biotechnology company developing ... other chronic diseases, announced that Catherine Bovenizer ... Financial Officer (CFO), effective today. Ms. ... experience in financial management for a variety of ... Most recently, Ms. Bovenizer was the Vice President ...
(Date:12/5/2016)... N.J. , Dec. 5, 2016  Eisai ... 3 open-label two-year study of rufinamide, which were ... American Epilepsy Society (AES) held from December 2-6 ... of final two-year safety, tolerability and cognitive data ... rufinamide experienced similar safety and tolerability profiles, cognitive ...
(Date:12/4/2016)... ... December 02, 2016 , ... A proposed ... businesses in federally funded research and development is welcome news for the photonics ... photonics . , As part of the National Defense Authorization Act (NDAA) compromise ...
(Date:12/4/2016)... CAMBRIDGE, Mass. and CAPE ... SystemOne, a company focused on connecting ... the developing world, and Daktari Diagnostics, a company ... its portable and ultrasensitive immunoassay-based CarePlatform™, today announced ... license agreement to integrate Daktari,s technology platform with ...
Breaking Biology Technology: