Navigation Links
Results of world's first gene therapy trial for arthritis show approach safe, feasible

Gene therapy for arthritis and other non-terminal, debilitating conditions and diseases is both feasible and safe, report researchers who conducted the world's first such test on the approach in patients with advanced rheumatoid arthritis. The results, published in this week's online edition of the Proceedings of the National Academy of Sciences (PNAS), indicate that introducing a new gene has the potential to block the destructive inflammation process that takes place within arthritic joints. At a time when setbacks have cast doubt on the future of gene therapy, the results also provide assurance that it can be performed without causing undue harm to patients.

The clinical trial, which was conducted at the University of Pittsburgh School of Medicine between 1996 and 1999, involved nine women who had genetically modified cells injected into their arthritic knuckles and marked the first time a gene was introduced into a human joint. The researchers say their results showing that successful gene transfer can target joint inflammation open the door to the development of improved gene-based therapies for both rheumatoid and the more common osteoarthritis, which together affect about 66 million people in the United States. While the Pitt study used the same vector ?an inactivated virus that shuttles a gene into cells ?as a more recent French trial for X-linked severe combined immunodeficiency (X-SCID) in which three children later developed leukemia, the researchers point out that this is the only similarity between the two trials. The studies were concerned with different genes and with different targets, and in the arthritis trial, the transduced cells were removed after one week during routine joint replacement surgery. Nonetheless, with safety a key concern, the authors report no clinical side effects up to five years after the procedure and no evidence that the vector, a replication-defective retrovirus called Maloney Murine Leukemia Virus, has since become c
'"/>

Source:Brigham and Women's Hospital


Page: 1 2 3 4

Related biology news :

1. Combating anthrax: Results of study published this month as researchers look for a better vaccine
2. Results with newer bladeless LASIK equivalent to standard microkeratome LASIK
3. PCRM develops worlds first cruelty-free insulin assay
4. Breakthrough: Scientists create worlds tiniest organic particles
5. Environmental lessons from tsunami as worlds coastal population doubles
6. New plant DNA libraries provides massive boost to worlds plant researchers
7. New book highlights worlds borderless conservation areas
8. Some good news for the worlds poor
9. New study of the worlds smallest elephant
10. The worlds deepest dinosaur finding - 2256 metres below the seabed
11. Scientists a step closer to protecting worlds most important crop
Post Your Comments:
(Date:9/19/2014)... legume plants regulate their symbiotic relationship with soil ... through the plant structure from leaves into the ... in the roots. This collaborative study was conducted ... Biology, the Graduate University for Advanced Studies (SOKENDAI), ... in Japan. , Legumes, an important plant ...
(Date:9/18/2014)... GSA Bulletin study uses tree rings to ... Chaco Wash in northern New Mexico, USA. By determining ... willow, investigators were able to precisely date arroyo sedimentary ... this data with aerial imagery, LiDAR, longitudinal profiles, and ... , Arroyos are deep, oversized channels that have vertical ...
(Date:9/18/2014)... USA Miranda, a small, icy moon of Uranus, ... bodies in the solar system. Despite its relatively small ... intense resurfacing that resulted in the formation of at ... regions called coronae. , These coronae are visible ... least 200 km across. Arden corona, the largest, has ...
Breaking Biology News(10 mins):For legume plants, a new route from shoot to root 2Tree rings and arroyos 2Tree rings and arroyos 3Tree rings and arroyos 4Tree rings and arroyos 5Tree rings and arroyos 6Tree rings and arroyos 7Miranda: An icy moon deformed by tidal heating 2Miranda: An icy moon deformed by tidal heating 3Miranda: An icy moon deformed by tidal heating 4Miranda: An icy moon deformed by tidal heating 5Miranda: An icy moon deformed by tidal heating 6Miranda: An icy moon deformed by tidal heating 7
... Fresh fruit and vegetables carry an abundance of bacteria on ... first study to assess the variety of these non-pathogenic bacteria, ... type of produce and cultivation practices. The results are published ... by Jonathan Leff and Noah Fierer at the University ...
... 100 women per day die from breast cancer in ... increase for women taking hormone replacement therapy to avoid ... Missouri scientist Salman Hyder may lead to treatments for ... along with an international team, found that hormone-therapy-related breast ...
... A recent study published in the Journal of ... property rights discourage subsequent scientific research. "The ... patent system is to provide incentives for the ... many have expressed concerns that patents may be impeding ...
Cached Biology News:Do intellectual property rights on existing technologies hinder subsequent innovation? 2
(Date:9/19/2014)... The new , Healthcare and Life Sciences Review , ... PharmaBoardroom.com for free download , looks beyond the ... in 2009, and the austerity measures that followed, to find ... of trouble. "Despite the crisis, Spain ... the general conditions to invest are favorable to the pharmaceutical ...
(Date:9/18/2014)... 2014 About POCT ... a clinical laboratory. It helps in making fast ... and medication. POCT is gaining popularity due to ... such as diabetes, heart disease, and obesity. It ... standardized to minimize errors during the diagnosis of ...
(Date:9/18/2014)... Mich. , Sept. 18, 2014  Health Enhancement Products, ... firm investigating early-stage algae bioactive compounds and metabolic processes, is ... the company,s board of directors. Ms. Nola E. Masterson ... investment advisor joined the board effective September 17, 2014. ... Masterson agree to join our board," states Andrew Dahl ...
(Date:9/18/2014)... D.C. (PRWEB) September 18, 2014 On ... Durbin and Sen. Jim Risch for National Lab Day ... projects from across the national laboratory system. Durbin and ... which aims to increase awareness of the reach of ... technologies and discoveries to address some of our nation's ...
Breaking Biology Technology:PharmaBoardroom Releases New Spain Pharmaceuticals Report 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 3POCT Market in China 2014-2018 2Health Enhancement Announces New Board Member In Advance Of Annual Shareholder Meeting 2Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 2Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 3
... MADISON - Rayovac and Sanyo have ... greater capacities and shorter charging times. , ,Sanyo will be ... recharge Nickel Metal Hydride, or NiMH, batteries in 15 minutes. ... a pressure control in each battery to regulates the charging ...
... Ken Schlager started a company, he looked to the ... around, Schlager is turning to the Center for Technology ... a cutting-edge technology that applies electromagnetic fields to wastewater ... a process that oxidizes wastewater and removes organic materials, ...
... technology drives business or business drives technology. Stop worrying ... rattling about how superior this technology is to that technology. ... if you have to ask, you probably already know and ... of inquiry is how much of your technological horsepower is ...
Cached Biology Technology:CTT - Bridging the states entrepreneurial gap 2CTT - Bridging the states entrepreneurial gap 3Technology as the engine of business innovation 2Technology as the engine of business innovation 3
Recognizes Kir4.1. The epitope does not share homology with any other known proteins.,SPECIES REACTIVITIES: The antibody is also expected to work with mouse and human due to sequence homology. Oth...
... Development kit contains the basic components required ... measure natural and recombinant mouse Dickkopf homolog-1 ... Each kit contains sufficient materials to run ... that the following conditions are met: ...
HIV-1 TAT (vN-21)...
Presenilin-1, N-terminus....
Biology Products: