Navigation Links
Restoring tamoxifen sensitivity in resistant breast cancer cells

tream. When estrogen binds to the estrogen receptor, it triggers a series of events that promote cell division. If the cell is a breast cancer cell, this interaction leads to tumor growth. In women with estrogen receptor-positive cancers, cancer cell growth is strongly influenced by estrogen.

Tamoxifen works by binding to estrogen receptors in place of estrogen and blocking the signals that lead to cell division. Initially, tumor growth slows or stops altogether. With continued tamoxifen treatment, however, the estrogen receptor and the estrogen-dependent signaling pathways in the cell can become altered, rendering tamoxifen ineffective as an inhibitor. In some cases, tamoxifen begins to act like estrogen and can stimulate tumor growth.

DIBA and related compounds are being studied because of their ability to disrupt cellular activity at the genetic level. These so-called electrophilic compounds were first investigated for possible use against AIDS because they can block the human immunodeficiency virus (HIV) from replicating. The HIV studies are ongoing.

"This basic study generated exciting results in our mouse model and suggests a promising approach that might be tried in human patients," said Farrar. His laboratory is now exploring ways to produce DIBA in a form that is water soluble so it could be administered as a pill, the same as tamoxifen. If successful, this could set the stage for preclinical studies.


'"/>

Source:SAIC-Frederick, Inc.


Page: 1 2

Related biology news :

1. Restoring silenced suppressor gene kills lung-cancer cells
2. Restoring seagrass beds: Is it for the birds?
3. Gene variation affects tamoxifens benefit for breast cancer
4. Pak1 expression increases tamoxifen resistance in breast cancer patients
5. Childrens taste sensitivity and food choices influenced by taste gene
6. Evolution of taste receptor may have shaped human sensitivity to toxic compounds
7. Assessing the Amazon Rivers sensitivity to deforestation
8. Global warming increases oyster sensitivity to pollution
9. Mutations in the BRAF gene predict sensitivity to a novel class of cancer drugs
10. Clock molecules sensitivity to lithium sheds light on bipolar disorder
11. Increased sensitivity to nerve signals keeps diabetes at bay
Post Your Comments:
(Date:10/18/2014)... of 2,000 patients referred for evaluation of suspected ... diagnosis for 25 percent, including detection of a ... contributing to disease, according to a study appearing ... released to coincide with the American Society of ... the exons or coding regions of thousands of ...
(Date:10/17/2014)... Copenhagen have shown for the first time how bacteria ... patients, giving them the opportunity to get tremendous insights ... The study also discovered the bacterial growth in chronic ... or slowed down by the immune cells. The researchers ... helped "suffocate" the bacteria, forcing the bacteria to switch ...
(Date:10/16/2014)... managers have a new synthesis of recent research findings ... forests in the two states. , The Ecology ... and Washington: A Synthesis of the Relevant Biophysical Science ... report published by the U.S. Forest Service,s Pacific Northwest ... from managers for a synthesis of the large body ...
Breaking Biology News(10 mins):Whole-exome sequencing shows potential as diagnostic tool 2Scientists opens black box on bacterial growth in cystic fibrosis lung infection 2New report synthesizes best available science on management of moist mixed-conifer forests 2
... southern portion of the Amazon rainforest is at a much ... projections made by the climate models used in the latest ... severe enough, the loss of rainforest could cause the release ... the atmosphere. It could also disrupt plant and animal communities ...
... Bethesda, MD FASEB MARC (Maximizing Access to Research ... the 2013 Institute on Teaching and Mentoring, Arlington, VA ... to promote the entry of underrepresented minority students, postdoctorates ... community. Awards are given to graduate students, postdocs ...
... in the hardest working plants in organic farming systems. ... subdue weeds, build productive soil, control pests and diseases, ... new study, the popular cover crop Vetch ( Vicia ... experiment. The experiment was designed to determine the effects ...
Cached Biology News:Risk of Amazon rainforest dieback is higher than IPCC projects 2Risk of Amazon rainforest dieback is higher than IPCC projects 3MARC travel awards announced for 2013 Institute on Teaching and Mentoring 2Vetch cover crop, fertilizer practices recommended for organic zucchini 2Vetch cover crop, fertilizer practices recommended for organic zucchini 3
(Date:10/19/2014)... The Latin American hardware encryption display market report defines ... and forecast of revenue. This market was valued at ... $2,366.8 million by 2018, at a CAGR of 70.3% ... of the Latin American hardware encryption market report to ... also provides a glimpse of the segmentation of the ...
(Date:10/19/2014)... The Asia-Pacific Bromine Market report defines ... analysis and forecast of revenue. , Browse through ... report, to get an idea of the in-depth ... the segmentation in the Asia-Pacific bromine market, and ... , http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html , Bromine is a ...
(Date:10/19/2014)... The report "Chocolate, Cocoa Beans, Lecithin, Sugar ... Trend and Forecast (2011 - 2016)," analyzes the ... studies the major market drivers, restraints, and opportunities for ... , The global chocolate market is expected to grow ... at an estimated CAGR of 2.7% from 2011 to ...
(Date:10/19/2014)... 19, 2014 According to market ... Points; WLAN Controllers; Wireless gateways)]- Global Advancements, Forecasts ... the global Outdoor Wi-Fi market with analysis and ... MarketsandMarkets also identifies the drivers and the restrains ... trends, opportunities and challenges. , Browse 65 market ...
Breaking Biology Technology:The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 2The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 3The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 2Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 4Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 2Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 3Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 4
... concern are attacks involving nuclear devices or materials. ... smuggled radioactive materials is considered vital to U.S. ... researchers at the Georgia Tech Research Institute (GTRI) ... used at ports, border crossings, airports and elsewhere. ...
... CAESAREA, Israel, May 1, 2012 CardioDex ... site closure device. Recent data from commercial use of the ... Germany showed 100% success rate and no complications. "We are ... device provides a viable treatment for a major unmet medical ...
... AnaptysBio, Inc., a privately-held therapeutic antibody company, today ... Inc. to develop novel antibody therapeutics. ... Under this partnership, antibodies generated by AnaptysBio using ... Gilead for worldwide development and commercialization. Gilead has paid ...
Cached Biology Technology:Novel radiation surveillance technology could help thwart nuclear terrorism 2Novel radiation surveillance technology could help thwart nuclear terrorism 3Novel radiation surveillance technology could help thwart nuclear terrorism 4New Revolutionary Femoral Access Site Closure Device Shows Unparalleled Efficacy, Safety & Ease of Use, in a Wide Range of Patients Including Patients With a Challenging Anatomy 2New Revolutionary Femoral Access Site Closure Device Shows Unparalleled Efficacy, Safety & Ease of Use, in a Wide Range of Patients Including Patients With a Challenging Anatomy 3AnaptysBio Announces Antibody Discovery Partnership With Gilead Sciences 2
Immunogen: VDAC3 Protein Storage: -20 C, Avoid Freeze/Thaw Cycles...
1000X solution used for inducing CopyControl™ based vectors to high copy numbers...
Consists of 4 separate 100mM solutions (ATP,GTP,CTP and UTP pH 7.5) as sodium salts. 98% Pure by HPLC...
Donor feline serum and plasma...
Biology Products: