Navigation Links
Restoring silenced suppressor gene kills lung-cancer cells

A new study suggests that restoring a gene often silenced in lung cancer causes the cells to self-destruct. The findings could lead to a new strategy for treating the disease.

The research focused on a gene known as WWOX, which is lost or silenced in a large majority of lung cancers, and in cancers of the breast, ovary, prostate, bladder, esophagus and pancreas. The work was led by scientists at The Ohio State University Comprehensive Cancer Center ? Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

The study showed that both in the laboratory and in animal experiments, restoring the missing or silenced WWOX gene can slow or stop the cells' growth.

The study also showed that the reactivated gene is highly effective in stopping the growth of human lung tumors that have been transplanted into mice.

The findings are published online in the Oct. 13 Early Edition of the Proceedings of the National Academy of Sciences.

The American Cancer Society expects more than 172,500 Americans to develop lung cancer in 2005, and more than 163,500 people to die of the disease, making it the most common cause of cancer death in the U.S.

"Our findings show that restoring the WWOX gene in lung-cancer cells that don't express it will kill that lung-cancer cell," says coauthor Kay Huebner, professor of molecular virology, immunology and medical genetics and a researcher with the OSU Comprehensive Cancer Center .

"This suggests that if this gene could be delivered to, or reactivated in, the tumor cells of lung-cancer cases that are deficient in this gene, it should have a therapeutic effect."

WWOX is a tumor suppressor gene. Tumor suppressor genes safeguard the body by triggering the death of cells that have sustained serious DNA damage before the cells become cancerous. The loss or silencing of tumor suppressor genes is a fundamental cause of tumor development.

The WWOX protein is missin
'"/>

Source:Ohio State University


Page: 1 2

Related biology news :

1. Restoring seagrass beds: Is it for the birds?
2. Restoring tamoxifen sensitivity in resistant breast cancer cells
3. Scientists identify molecule that regulates well-known tumor suppressor
4. New tumor-suppressor gene discovered
5. Natural tumor suppressor in body discovered by UCSD medical researchers
6. Researchers discover how tumor suppressor gene works
7. Little known DNA repair enzyme may be a tumor suppressor gene
8. Researchers uncover new mechanism of tumor suppressor
9. Structure determined for p53 tumor suppressor protein as bound to DNA for anti-cancer activity
10. Novel regulatory mechanism identified for key tumor suppressor p53
11. MicroRNAs can be tumor suppressors
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Restoring silenced suppressor gene kills lung cancer cells

(Date:8/20/2014)... -- Bay Area Lyme Foundation, which aims to make ... applauds new research published in an upcoming issue of ... Diseases . The findings show that ticks that ... the year, making the threat of Lyme disease year-round. ... of Public Health (CDPH) Vector-borne Disease Section and University ...
(Date:8/20/2014)... who have suffered concussions ready to return to action? ... high school athletes who head back on the field ... regression in their abilities to simultaneously walk and do ... changes in their balance and/or altered walking speed, was ... 12 had returned to activity in less than a ...
(Date:8/20/2014)... Virginia Tech,s Wu Feng has built upon a National ... in the Cloud" program, and synergistically complemented it with ... the Air Force on "big computing" for mini-drones and ... Institutes of Health on "big data" for the life ... aspects from each grant, he was able to tell ...
Breaking Biology News(10 mins):Lyme disease risk is year-round in Northwest California, according to new study 2Lyme disease risk is year-round in Northwest California, according to new study 3Recovery reversal seen in Oregon study of returning concussed athletes 2Recovery reversal seen in Oregon study of returning concussed athletes 3The internet was delivered to the masses; parallel computing is not far behind 2The internet was delivered to the masses; parallel computing is not far behind 3The internet was delivered to the masses; parallel computing is not far behind 4
... Virtually all babies in the U.S. have their heels ... for genetic testing. These "heel stick" tests identify rare ... more disorders are added to the screening ?many states ... on the rise. In the June issue of Pediatrics, ...
... of their parents may give birds a preference for ... more exactly match those of their parents. Such learned ... traits and strong morphological differences between sexes ?phenomena seen ... reported by Carel ten Cate, Machteld Verzijden and Eric ...
... sub-Saharan Africa, according to the World Health Organization, and ... achieved limited success. But what if a vaccine against ... of Africa ?chancroid ?was relatively easy to develop and ... , That may be the case, according to researchers ...
Cached Biology News:Newborn screening can cause unnecessary parental stress 2Newborn screening can cause unnecessary parental stress 3Zebra finch males prefer females with exaggerated maternal traits 2Vaccine shown effective against chancroid 2Vaccine shown effective against chancroid 3
(Date:8/18/2014)... Tampa, FL (Aug. 18, 2014) -- A new ... South Florida (USF) Morsani College of Medicine and ... the life-threatening complications of interventional cardiovascular disease treatment. ... model that the novel molecular therapy could selectively ... healing following a medical procedure using a balloon ...
(Date:8/18/2014)... Aug. 18, 2014 BioElectronics Corporation ... consumer medical devices said that its EVP ... by CEOLIVE.TV as part of its Executive ... is available at http://ceolive.tv/bioelectronics-corp-otc-biel/biel-videos/2282-ceolive-tv-interview-bioelectronics-corp-otcqb-biel ... to investors the unique advantages of BioElectronics ...
(Date:8/18/2014)... efficiency and data storage may someday run ... polarizations to read and write digital information, ... technology. But ferroelectrics must first overcome a ... habit of "forgetting" stored data. , ... Energy,s Brookhaven National Laboratory have discovered nanoscale ...
(Date:8/18/2014)... August 18, 2014 According ... Market Research "Life Science Reagents Market(Products- PCR Reagent ... Chromatography, In-Vitro Diagnostic Reagents and Others; End Users- ... Clinical Laboratories, and Forensic Laboratories)- Global Industry Analysis, ... 2019", the global life science reagents market was ...
Breaking Biology Technology:Selective therapy may improve artery repair after interventional cardiovascular procedures 2Selective therapy may improve artery repair after interventional cardiovascular procedures 3BioElectronics EVP Dr. Deepak Kotak Interviewed on CEO Live 2BioElectronics EVP Dr. Deepak Kotak Interviewed on CEO Live 3Promising ferroelectric materials suffer from unexpected electric polarizations 2Promising ferroelectric materials suffer from unexpected electric polarizations 3Promising ferroelectric materials suffer from unexpected electric polarizations 4Global Life Science Reagents Market Expected to Reach USD 25.7 Billion in 2019: Transparency Market Research 2Global Life Science Reagents Market Expected to Reach USD 25.7 Billion in 2019: Transparency Market Research 3Global Life Science Reagents Market Expected to Reach USD 25.7 Billion in 2019: Transparency Market Research 4Global Life Science Reagents Market Expected to Reach USD 25.7 Billion in 2019: Transparency Market Research 5
... - ARIUS Research Inc., (TSX:,ARI), a biotechnology company ... today announced that David Young, MD, President and,Chief ... Chinese Global,Financial Forum. Dr. Young will present on ... available prior to and following his presentation at ...
... DuPont Chairman and,CEO Charles O. Holliday, Jr., today told ... the world to keep pace with the rapid,growth in ... "Biotechnology is the most powerful tool available to secure ... holds the promise,to deliver the world more, higher quality ...
... Angiotech Pharmaceuticals,Inc. (NASDAQ: ANPI , TSX: ... company, today announced preliminary financial results from,the ... updated its financial,outlook for the full year ... the,release of Boston Scientific Corporation,s (BSC) third ...
Cached Biology Technology:ARIUS to present at Chinese Global Financial Forum 2Biotechnology Needed to Help Meet Growing Global Needs for Food, Feed, Fuel and Materials, DuPont Chairman & CEO Says at World Food Prize 2Angiotech announces preliminary third quarter financial results and updates fiscal 2007 outlook 2Angiotech announces preliminary third quarter financial results and updates fiscal 2007 outlook 3Angiotech announces preliminary third quarter financial results and updates fiscal 2007 outlook 4Angiotech announces preliminary third quarter financial results and updates fiscal 2007 outlook 5Angiotech announces preliminary third quarter financial results and updates fiscal 2007 outlook 6Angiotech announces preliminary third quarter financial results and updates fiscal 2007 outlook 7Angiotech announces preliminary third quarter financial results and updates fiscal 2007 outlook 8Angiotech announces preliminary third quarter financial results and updates fiscal 2007 outlook 9Angiotech announces preliminary third quarter financial results and updates fiscal 2007 outlook 10Angiotech announces preliminary third quarter financial results and updates fiscal 2007 outlook 11
Hepatocyte Differentiation Environment...
High voltage electrophoresis power supply...
Mouse monoclonal antibody to ANAPC2 - anaphase promoting complex subunit 2...
... Drummond Scientific has a long and ... microinjection apparatus. Several years ago we ... displacement microdispenser was being modified to ... unit by redesigning the microdispenser to ...
Biology Products: