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Resistant HIV quickly hides in infants' cells

IDS will require not only prevention of mother-to-child transmission but also development of new antiretroviral agents for pediatric use, particularly against highly resistant infection. "There is also a need for new and widely accessible methods for detecting HIV infection in infants, whether resistant or not," he pointed out, "since transplacental transfer of maternal antibodies precludes the use of antibody detection methods." Affordable techniques also are necessary to reliably detect resistant HIV in less affluent areas of the world.

SUGGESTED "FAST FACTS":

  1. Five of 21 HIV-positive infants in this study were infected with drug-resistant HIV transmitted from their mothers.
  2. These drug-resistant strains in quickly took up residence in inactive T cells, from where they could later launch an attack that NNRTIs could not stop. Protease inhibitors were still effective, however.
  3. These results suggest that drug resistance testing of viruses from HIV infected infants before treatment should be implemented wherever feasible.

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Source:Infectious Diseases Society of America


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