Navigation Links
Researches discover gene critical for protection against septic-shock-induced death

Disruption of a single gene, Nrf2, plays a critical role in regulating the body's innate immune response to sepsis and septic shock, according to a study by a research team led by Shyam Biswal, PhD, at the Johns Hopkins Bloomberg School of Public Health.

The researchers found that the absence of Nrf2 caused a dramatic increase in mortality due to septic shock in mice. The study's findings, which will be published in the April 2006 issue of the Journal of Clinical Investigation, may hold potential for the treatment of life-threatening sepsis.

Sepsis is a complex disease characterized by an increased inflammatory response in the body's attempt to combat an infection from microorganisms such as bacteria, fungi or viruses. A weak host inflammatory response can lead to greater infection, whereas an excessive inflammatory response may lead to tissue damage, myocardial injury, acute respiratory failure, multiple organ failure or death. Controlling inflammation is thus a central focus of treating sepsis. Researchers have been hunting for novel host genes that regulate inflammation as potential targets for the next generation of sepsis therapies. The incidence of sepsis in the United States ranges from 400,000 to 750,000 cases per year. Mortality due to sepsis is around 30 percent and increases with age from 10 percent in children to 40 percent in the elderly. Mortality is 50 percent or greater in patients with the more severe syndrome, septic shock.

Suspecting that a dysregulation in the body's inflammatory response exacerbates sepsis, the research team began looking into the genetic factors that might contribute to this syndrome. In 2002, Biswal and his colleagues discovered that Nrf2 acts as a primary regulator of most of the cellular antioxidant pathways and detoxifying enzymes that protect the body from a wide variety of environmental toxicants. In subsequent studies, they discovered that Nrf2 is a pleiotropic protein thatregulates a broad spectr
'"/>

Source:Johns Hopkins University Bloomberg School of Public Health


Page: 1 2 3

Related biology news :

1. UAB scientists discover the origin of a mysterious physical force
2. Researchers discover way to make cells in the eye sensitive to light
3. Protein discovery could unlock the secret to better TB treatment
4. Newly-discovered class of genes determines ?and restricts ?stem cell fate
5. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
6. Purdue proves concept of using nano-materials for drug discovery
7. Scientists discover the cellular roots of graying hair
8. Researchers discover molecule that causes secondary stroke
9. Scientists discover unique microbe in Californias largest lake
10. New protein discovered by Hebrew University researchers
11. UCSD discovery may help extend life of natural pesticide
Post Your Comments:
(Date:5/21/2013)... American Chemical Society (ACS), the world,s largest scientific ... National Meeting & Exposition, September 8-12, 2013, in ... Indiana Convention Center and at area hotels. , ... that span science,s horizons from astronomy to ... and online journalists a rich assortment of spot ...
(Date:5/21/2013)... largest gathering of biomass experts , Where? ... When? 03-07 June 2013 , ... research, resource assessment, market and policy developments, manufacturing and ... world and benefiting from its 2013 edition from a ... than 60 countries, more than 240 plenary and oral ...
(Date:5/21/2013)... 21, 2013 Royal Philips Electronics (NYSE: PHG, ... first portable ultrasound with Philips, industry leading Live 3D ... CX50 xMATRIX with available Live 3D TEE and ICE ... at the EuroPCR, official meeting for the European Association ... Since its launch in 2012, Philips CX50 xMATRIX has ...
Breaking Biology News(10 mins):21st European Biomass Conference and Exhibition 221st European Biomass Conference and Exhibition 321st European Biomass Conference and Exhibition 4Philips CX50 xMATRIX now offers world-class interventional and diagnostic features on single portable system 2
... Rochelle, NY, March 4, 2009--The disposable bioprocessing market ... preparation toward a range of products for cell ... Genetic Engineering & Biotechnology News (GEN). Increasing ... completely disposable bioprocess stream is feasible and even ...
... that dramatically strengthens stem cells, ability to regenerate damaged ... diseases such as myopathy and muscular dystrophy, according to ... The world-first procedure has been successfully used to ... be applied to all tissue-based illnesses in humans such ...
... athletes suddenly collapse, it can be due to hereditary cardiac ... a genetic modification that leads to cardiac weakness in an ... a heart condition. Since the fish have a genetic makeup ... for humans as well. Cardiac insufficiency is ...
Cached Biology News:GEN reports biomanufacturers target a fully disposable process stream 2Stem cell breakthrough gives new hope to sufferers of muscle-wasting diseases 2Why 'lazy Susan' has a weak heart 2
(Date:5/22/2013)... 2013  Cleveland BioLabs, Inc. (NASDAQ: CBLI) today announced that ... Marcum LLP Microcap Conference, May 30, in New ... Lyons , CPA, Chief Financial Officer of Cleveland BioLabs, ... 30 at 1:30 p.m. Eastern Time.  A live and archived ... Investors page of the Cleveland BioLabs website at www.cbiolabs.com ...
(Date:5/22/2013)... (PRWEB) May 22, 2013 Alton Housing Authority ... May 15, 2013 said that their presence has already ... bed bug sufferers avoid such big spending, My Cleaning Products ... inexpensively. , It was said in the report that to ... MCP related. Apart from that, its employees also attended a ...
(Date:5/22/2013)... 22, 2013  Moderna Therapeutics, the pioneering company developing ... enable the in vivo production of therapeutic ... will join Moderna in early July as its ... a proven leader in the design and implementation of ... discovery to translation, clinical operations and commercial preparedness. John ...
(Date:5/21/2013)... (PRWEB) May 21, 2013 Custom ... to reporting eLearning solution using Tin Can API ... dashboard tool. CLD is a leading developer of ... medical device companies worldwide. , Tin Can ... that helps learners and trainers more accurately measure ...
Breaking Biology Technology:Cleveland BioLabs to Present at Second Annual Marcum LLP Microcap Conference 2Bed Bugs Cost Alton Housing Authority $35,000; New Help, How to Kill Bed Bugs With Less Expense, Introduced by My Cleaning Products 2Industry Leader John Reynders Joins Moderna Therapeutics as Chief Information Officer 2Industry Leader John Reynders Joins Moderna Therapeutics as Chief Information Officer 3CLD Integrates Tin CAN API with its eLearning Solutions and Launches its Excelerometer Tracking Statement Dashboard 2CLD Integrates Tin CAN API with its eLearning Solutions and Launches its Excelerometer Tracking Statement Dashboard 3
... the State speech that is anything less than optimistic, and ... or Democrat, riding high in the polls or battling mediocre ... the State speech to inspire, cajole and sprinkle a few ... to the state was no exception. , ,But how ...
... a visit to Sheboygan that the region could be a ... on Madison and Milwaukee. , ,A professor at Lakeland College ... work in local biotechnology companies, if the jobs were available. ... find jobs elsewhere, is a concern across Wisconsin. , ,At ...
... retrospectively reviewing what happened to major pharma and biotech companies, including ... investor perspective as reflected in a stock price and resultant valuation ... look at and value the impact of our industry. One such ... Companies to Work For 2006 published on January 11th. ...
Cached Biology Technology:How's the State of the State? It depends on what numbers are crunched 2How's the State of the State? It depends on what numbers are crunched 3Biotech leads list of top U.S. companies to work for 2Biotech leads list of top U.S. companies to work for 3Biotech leads list of top U.S. companies to work for 4Biotech leads list of top U.S. companies to work for 5
...
... is obtained from non-demolished blood ... fasted donors. The donors are ... and are maintained on an ... Protein Concentration : 85 mg/ml ...
Hamster serum...
... Filter Plates are offered in several versions. ... depth filter plates are ideal to prepare ... is simple, versatile, and necessary to prevent ... 10 um glass fiber and 20 um ...
Biology Products: