Navigation Links
Researchers wake up viruses inside tumors to image and then destroy cancers

Researchers have found a way to activate Epstein-Barr viruses inside tumors as a way to identify patients whose infection can then be manipulated to destroy their tumors. They say this strategy could offer a novel way of treating many cancers associated with Epstein-Barr, including at least four different types of lymphoma and nasopharyngeal and gastric cancers.

In the March 1 issue of Clinical Cancer Research, a team of radiologists and oncologists from Johns Hopkins Medical Institutions describe how they used two agents already on the market ?one of which is the multiple myeloma drug Velcade ?to light up tumor viruses on a gamma camera. The technique is the first in the new field of in vivo molecular-genetic imaging that doesn't require transfecting tumors with a "reporter" gene, the scientists say.

"The beauty of this is that you don't have to introduce any reporter genes into the tumor because they are already there," says radiologist Martin G. Pomper, M.D., Ph.D. "This is the only example we know of where it is possible to image activated endogenous gene expression without having to transfect cells."

A variety of blood and solid cancers are more likely to occur in people who have been infected with the Epstein-Barr virus (EBV), but not everyone with these cancers has such infections. For those who do, researchers, such as Hopkins oncologist and co-author Richard F. Ambinder, M.D., Ph.D., have been working on ways to activate the reproductive, or "lytic" cycle, within the virus to make it replicate within the tumor cell. When enough viral particles are produced, the tumor will burst, releasing the virus. In animal experiments, this experimental therapy, called lytic induction therapy, results in tumor death.

As the first step in this study, researchers screened a wide variety of drugs to see if any of them could reawaken the virus. They were fortunate in that one of the genes that is expressed upon viral lytic induction is E
'"/>

Source:American Association for Cancer Research


Page: 1 2 3

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
(Date:4/8/2015)... 8, 2015  Infinisource, a leading provider of SaaS-based ... Morpho, a leading supplier of biometric identification and ... market,s most advanced biometrically-enabled time clock, the companies ... clock is setting a bold, new standard for ... the small and mid-size employer. When connected to ...
(Date:4/2/2015)... , April 2, 2015 Fingerprint ... fingerprint sensor FPC1025 from the distributor World Peace Industrial ... during Q2 2015 although the major part of the ... will be used by smartphone manufacturers in ... is included in the communicated revenue guidance of + ...
(Date:3/30/2015)... 26, 2015 Research and Markets ( ... "Global Gesture Recognition Market in Automotive Sector 2014-2018" ... the Global Gesture Recognition market in Automotive Sector to ... 2013-2018. Gesture recognition is the ability of ... of an individual. Gesture recognition technology can be 2D-based ...
Breaking Biology News(10 mins):iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2
... many genes likely influence how tall a person grows, though ... genes. Now an international research team brings light to this ... height the first consistent genetic link to be reported. ... edition of Nature Genetics, stem from a large-scale effort led ...
... Harvard University have identified the ancient fossilized remains of a ... fossil record, a find they say suggests orchids are old ... this week in the journal Nature, indicates orchids arose some ... many scientists had estimated. The extinct bee they studied, preserved ...
... 30, 2007) Saudi Arabias King Abdullah University of ... Institute of Technology, Bombay (IIT Bombay) , signed a ... work together to foster world-class programs that will advance ... and applied chemical sciences for the benefit of their ...
Cached Biology News:Genome study shines light on genetic link to height 2Genome study shines light on genetic link to height 3First orchid fossil puts showy blooms at some 80 million years old 2First orchid fossil puts showy blooms at some 80 million years old 3Saudi Arabia's KAUST and IIT, Bombay to Collaborate on Scientific Research 2
(Date:4/23/2015)... Six startups from Russia traveled ... as part of the U.S.-Russia Innovation Corridor (USRIC) ... biotechnology startups to participate in the program since ... the University of Maryland (UMD) signed a Memorandum ... universities in the biomedical industry in 2013. , ...
(Date:4/23/2015)... 2015 Follow us on ... series of genetic tests that determine individual susceptibility ... disease, Huntington's disease, and Alzheimer's disease. Predictive diagnostics ... and interaction in diseased tissue/cells to understand and ... the response to treatment, such as in the ...
(Date:4/23/2015)... Prospects for Leading Companies in OTC, Rx ... We predict the global healthcare packaging market ... and will grow at a CAGR of 6.3% between 2015 ... world and increasing functional requirements for healthcare packaging products are ... packaging market. A global ageing population, changing lifestyles ...
(Date:4/23/2015)... , April 23, 2015  Metanome, Inc., an ... the company has changed its name to Diversigen, ... positioning as the single commercial source for the ... capitalize on the diverse opportunities of the microbiome. ... Diversigen accepts – including those that are difficult ...
Breaking Biology Technology:U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 2U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 3U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 4Increasing Disease Prevalence & Focus on Preventive Healthcare Drive the Predictive Diagnostics Market, According to a New Report by Global Industry Analysts, Inc. 2Increasing Disease Prevalence & Focus on Preventive Healthcare Drive the Predictive Diagnostics Market, According to a New Report by Global Industry Analysts, Inc. 3Healthcare Packaging Market Forecast 2015-2025 2Healthcare Packaging Market Forecast 2015-2025 3Healthcare Packaging Market Forecast 2015-2025 4Healthcare Packaging Market Forecast 2015-2025 5Healthcare Packaging Market Forecast 2015-2025 6Healthcare Packaging Market Forecast 2015-2025 7Healthcare Packaging Market Forecast 2015-2025 8Healthcare Packaging Market Forecast 2015-2025 9Healthcare Packaging Market Forecast 2015-2025 10Metanome Announces Corporate Name Change to Diversigen 2
... of Ocean Earth Science and Technology (SOEST) completed a ... 5 (HI-05), a deep-water military munitions disposal site in ... Harbor, Oahu, Hawaii. This complex investigation required the ... vehicles to locate sea disposed munitions in water as ...
... 17 Generex Biotechnology Corporation (Nasdaq: GNBT ... Eagle, an independent scientific advisor to the Company and ... the following statement in respect of the reverse stock ... the Generex stockholders: "Developing new medical therapies ...
... NORWALK, Conn., Oct. 15 UBM Medica today announces ... ) from MediSpecialty.com, Inc.   OBGYN.net is ... and patients.  The site provides article-based and multimedia content ... online forums – some of which have been running ...
Cached Biology Technology:University of Hawaii completes 3-year investigation of military munitions sea disposal site 2University of Hawaii completes 3-year investigation of military munitions sea disposal site 3Generex Scientific Advisor Weighs in on Reverse Stock Split Proposal 2Generex Scientific Advisor Weighs in on Reverse Stock Split Proposal 3Generex Scientific Advisor Weighs in on Reverse Stock Split Proposal 4UBM Medica Acquires Leading Online Community OBGYN.net 2UBM Medica Acquires Leading Online Community OBGYN.net 3