Navigation Links
Researchers use dirt to stay one step ahead of antibiotic resistance

Dirt may be a key to how bacteria that infect humans develop a resistance to antibiotic drugs.

In an article in the January 20 issue of the journal Science, McMaster University researchers say that study of bacteria found in dirt may be the key in identifying how and why antibiotic resistance happens in bacteria that infect people, predicting future clinical problems, and testing new antibiotics.

Antibiotic resistance has become an increasing public health concern because the organisms that cause infections in humans and animals are becoming less receptive to the healing aspect of antibiotic drugs.

The team led by professor Gerry Wright, chair of Biochemistry and Biomedical Sciences of the Michael G. DeGroote School of Medicine, found that the numerous ways soil-dwelling bacteria become resistant to antibiotics are identical to the resistance patterns seen in patients.

These soil-dwelling bacteria also play a central role in the treatment of infectious diseases. Approximately two-thirds of all known antibiotics are produced by bacteria called actinomycetes, commonly found in soils, compost, and other environmental sources.

"By evolving in an environment of antibiotic production, incredibly resilient bacteria must develop diverse ways to survive or resist the toxic antimicrobial compounds produced by their neighbors," said Wright. "Their coping tactics may be able to give us a glimpse into the future of clinical resistance to antibiotics."

"This research suggests that not only can the study of resistance in the soil help predict future clinical emergence, but it can also guide the development of therapies to counteract this resistance."

Researchers screened 480 strains of soil bacteria isolated from diverse locations for resistance to 21 clinically relevant antibiotics. At high drug concentrations, the soil-dwelling bacteria displayed a stunning level of resistance. Not only were the bacteria resistant to an average of seven to eight antibiotics, but every strain was found to be multi-drug resistant.

The bacteria showed resistance to all major classes of antibiotics, regardless of whether the compounds were naturally produced, semi-synthetic, or completely synthetic.

Researchers also found that the way bacteria was resistant to vancomycin, one of the most commonly prescribed antibiotics for drug resistant staphylococcal infections, was identical to resistance found in clinics.

Furthermore, the researchers' uncovered bacteria that produced enzymes capable of breaking down or modifying or rendering inactive two recently U.S. FDA-approved antibiotics, a situation which has yet to emerge clinically for these drugs.

"The link between clinical and soil-associated resistance to vancomycin illustrates the value of studying resistance in the soil to rationally anticipate future clinical resistance," said Wright. "It suggests that the soil serves as an under-recognized source of resistance, resistance that has the potential to reach clinics.

"This work could prove to be extremely valuable to the drug development process, complementing traditional laboratory studies of clinical situations. By screening newly developed drugs for resistance in soil bacteria, not only can pharmaceutical companies can gain a better understanding of what may emerge in the future as clinical problems, but sufficient warning can be given to hospital microbiology laboratories, physicians and the drug discovery sector to allow for the development of diagnostic techniques and alternative therapies.

"Furthermore, studying enzymes that inactivate antibiotics can serve as a foundation for the development of new combination therapies for resistant bacterial strains. Studying antibiotic resistance from an evolutionary perspective is one way that researchers are attempting to stay one step ahead of resistant bacteria."

Antibiotic resistant bacteria have become a major health threat andhave limited our ability to treat even common infections withantibiotics," said Dr. Bhagirath Singh, Scientific Director of theCanadian Institutes of Health Research Institute of Infection andImmunity. "Dr. Wright's exciting discovery points to the fact that innature, bugs in the soil survive in a very hostile environment. They dothis by developing resistance to the antibiotics produced by other soilbacteria. Understanding this process opens up a new avenue for findingnew therapies to prevent and treat antibiotic resistance in a clinicalsetting.


'"/>

Source:McMaster University


Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/6/2016)... , Dec. 6, 2016  Zimmer Biomet Holdings, Inc. ... has priced an offering of €500.0 million principal amount of ... principal amount of its 2.425% senior unsecured notes due 2026. ... to occur on December 13, 2016, subject to the satisfaction of ... annual basis. The Company intends ...
(Date:12/6/2016)... , Dec. 6, 2016 Valencell , the ... it has seen a third consecutive year of triple ... technology in 2016 with a 360 percent increase in ... This increase was driven by sales of its wrist ... interest in its technology for hearables for fitness and ...
(Date:12/6/2016)... Dec. 6, 2016 Securus Technologies, a ... solutions for public safety, investigation, corrections and monitoring, ... today a five (5) year funding commitment by ... expand the rehabilitation and reentry support to more ... Established in 2004, the Prison Entrepreneurship Program (PEP) ...
Breaking Biology News(10 mins):
(Date:12/7/2016)... (PRWEB) , ... December 07, 2016 , ... ... http://www.autoreactors.com and online shopping cart. The new website has been designed ... These essential digital components allow customers to access detailed product information, read educational ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... early access program for SmartBiome -- a novel metagenomic deep-sequencing research platform. ... enrichment and detection of hundreds of different genes. The selective early access ...
(Date:12/7/2016)... ... , ... Kara Dwyer Dodge grew up hearing stories of the sea monster her father pulled ... a sea turtle entangled in the lines of one of his lobster pots. He freed ... no one could remember ever seeing one so large so close to shore. After a ...
(Date:12/6/2016)... , Dec. 6, 2016 The American Botanical ... adoption of arnica ( Arnica montana ) through ... ABC,s HerbMedPro database, a comprehensive, interactive ... and clinical research data on the uses and ... Naturopathica, a wellness company with healing ...
Breaking Biology Technology: