Navigation Links
Researchers unlock how cells determine their functions

Researchers at the University of California, Riverside have discovered a molecular mechanism directing the fate and function of cells during animal development. The findings could hold promise for the advancement of cancer and stem-cell research.

The research is published in the Feb. 24 edition of the journal Science. UCR Biochemistry Professor Frank Sauer, with German colleague Elisabeth Kremmer of the Institut für Molekulare Immunologie in Munich, and fellow UCR researchers Tilman Sanchez-Elsner and Dawei Gou authored the paper titled, Noncoding RNAs of Trithorax Response Elements Recruit Drosophila Ash1 to Ultrabithorax.

The paper explains how proteins, known as epigenetic activators (such as Ash1 from the fruit fly Drosophila), bind to their target DNA and activate genes that determine what function a cell will have in the body.

"The fact that these epigenetic activators, such as Ash1, turn on the expression of specific target genes has been known for some time. However, the mechanisms by which epigenetic activators recognize and bind these target genes was not yet known" Sauer pointed out

"What we were able to show is that the epigenetic activator Ash1is recruited to a target gene through cell-type specific non-coding RNA" he said.

The paper examined how the activator Ash1 binds to target DNA elements, known as Trithorax-reponse elements (TREs), located in the gene Ultrabithorax (Ubx). Non-coding RNA is produced by and retained at the TREs of Ubx, and helps activate the expression of the Ubx gene by attracting Ash1 to the TREs. The transgenic transcription of non-coding TRE RNA can change the type and function of cells.

"As a result, we can now use non-coding RNAs as tools to actively determine cell fate," Sauer said."Over the last few years, researchers have focused on how noncoding RNAs silence genes," said Anthony Carter, of the National Institute of General Medical Sciences, which partially funded the resea rch. "Dr. Sauer's work has revealed that noncoding RNAs have a broader range of functions than was previously known, and suggests a model for how they can help activate, rather than silence, a key regulator of animal development."


'"/>

Source:University of California - Riverside


Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2016)... , April 13, 2016  IMPOWER physicians supporting Medicaid ... setting a new clinical standard in telehealth thanks to ... leveraging the higi platform, IMPOWER patients can routinely track ... and body mass index, and, when they opt in, ... convenient visit to a local retail location at no ...
(Date:3/23/2016)... WAKEFIELD, Massachusetts , March 23, 2016 ... kombiniert im Interesse erhöhter Sicherheit Gesichts- und ... Xura, Inc. (NASDAQ: MESG ... heute bekannt, dass das Unternehmen mit SpeechPro ... insbesondere aus der Finanzdienstleistungsbranche, wird die Möglichkeit ...
(Date:3/18/2016)... -- --> --> Competitive ... Unmanned Vehicles, Physical infrastructure and Perimeter Surveillance & Detection Systems ... security market and the continuing migration crisis in the ... has led visiongain to publish this unique report, which ... defence & security companies in the border security market ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... ... April 27, 2016 , ... Cambridge Semantics, the ... technology, today announced that it has been named to The Silicon Review’s “20 Fastest ... and other markets, Cambridge Semantics serves the needs of end users facing some of ...
(Date:4/27/2016)... ... ... Pittcon Organizing Committee is pleased to announce that Charles “Chuck” Gardner was named president ... Since then, he has served in a number of key leadership positions including secretary ... and exposition committees. In his professional career, Dr. Gardner is the director of product ...
(Date:4/27/2016)... , April 27, 2016 ... (CSE: NSK) (OTCPink: NSKQB) ( Frankfurt ... an ihre Pressemitteilung vom 13. August 2015 die ... ihre Finanzen um zusätzliche 200.000.000 Einheiten auf 400.000.000 ... Dollar zu bringen. Davon wurden 157.900.000 Einheiten mit ...
(Date:4/27/2016)... ... April 27, 2016 , ... ... pleased to announce the appointment of John Tilton as Chief Commercial Officer.  Mr. ... and one of the founding commercial leaders responsible for the commercialization of multiple ...
Breaking Biology Technology: