Navigation Links
Researchers uncover new mechanism of tumor suppressor

Researchers from the University of Colorado-Denver and Health Sciences Center and Stanford University have discovered a molecular mechanism that explains how cells respond to DNA damage and other acute stresses, and if disrupted can cause cancer. Their findings, which could lead to new diagnostic markers and cancer treatments with fewer side effects, will appear in two reports in the May 21 advanced online version of the journal Nature.

The studies, led by Tatiana Kutateladze, PhD, an assistant professor in the UCDHSC Department of Pharmacology, and Or Gozani, MD, PhD, an assistant professor in the Department of Biological Sciences at Stanford University, revealed the significance of a novel function of the recently discovered tumor-suppressive molecule, which is thought to inhibit cancer formation and growth. These findings highlight a new mechanism to regulate gene expression programs that allow for appropriate responses to DNA damage in normal cells. When the process breaks down, such damage and other acute stresses are thought to lead to cancer.

The first study, Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2, was conducted in Kutateladze's laboratory with the assistance of graduate student Pedro Peña and research assistant Foteini Davrazou. Other co-authors include Rui Zhao, PhD, an assistant professor in the UCDHSC Department of Biochemistry and Molecular Genetics; Or Gozani, Xiaobing Shi and Kay L. Walter from Stanford University's Department of Biological Sciences; and Vladislav V. Verkhusha from the Department of Anatomy and Structural Biology at the Albert Einstein College of Medicine in New York.

The paper based on their work describes the structural aspects of the tumor suppressor action, while functional studies were accomplished by Gozani's group, and are the subject of the second report that will appear in Nature titled ING2 PHD domain links histone H3 lysine 4 methylation to active gene repress ion.

"Our findings have established the mechanistic principles by which the inhibitor of growth 2 tumor suppressor recognizes chromatin and regulates cell growth, proliferation, stress responses and aging. We hope this discovery opens up new opportunities to establish novel targets to prevent and treat cancer," said Kutateladze, a NARSAD Young Investigator and an American Cancer Society Research Scholar.

Research in Kutateladze's laboratory focuses on molecular mechanisms underlying signaling and regulation by chromatin- and lipid-binding biomolecules implicated in cancer and other human diseases. She employs high field Nuclear Magnetic Resonance spectroscopy, X-ray crystallography and other biochemical and biophysical approaches to elucidate three-dimensional atomic-resolution structures and dynamics of proteins to better understand their physiological functions and relevance to diseases.


'"/>

Source:Stanford University


Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)... May 16, 2017   Bridge Patient Portal ... and MD EMR Systems , an electronic ... for GE, have established a partnership to build ... and the GE Centricity™ products, including Centricity Practice ... These new integrations will allow healthcare ...
(Date:4/24/2017)... , April 24, 2017 Janice ... partner with  Identity Strategy Partners, LLP (IdSP) , ... or without President Trump,s March 6, 2017 ... Entry , refugee vetting can be instilled with greater ... (Right now, all refugee applications are suspended by ...
(Date:4/18/2017)... 2017  Socionext Inc., a global expert in SoC-based imaging and ... the M820, which features the company,s hybrid codec technology. A demonstration ... Probe, Inc., will be showcased during the upcoming Medtec Japan at ... the Las Vegas Convention Center April 24-27. ... Click here for an ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... ... its endogenous context, enabling overexpression experiments and avoiding the use of exogenous expression ... guides is transformative for performing systematic gain-of-function studies. , This complement to ...
(Date:10/11/2017)... -- VMS BioMarketing, a leading provider of patient support solutions, has ... (CNE) network, which will launch this week. The VMS CNEs ... professionals to enhance the patient care experience by delivering peer-to-peer ... care professionals to help women who have been diagnosed and ... ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... granted orphan drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator ... osteosarcoma. SBT-100 is able to cross the cell membrane and bind intracellular STAT3 ...
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder and CEO of ... Rotary Club. The event entitled “Stem Cells and Their Regenerative Powers,” ... Dr. Harman, DVM, MPVM was joined by two human doctors: Peter B. Hanson, ...
Breaking Biology Technology: