Navigation Links
Researchers uncover new mechanism of tumor suppressor

Researchers from the University of Colorado-Denver and Health Sciences Center and Stanford University have discovered a molecular mechanism that explains how cells respond to DNA damage and other acute stresses, and if disrupted can cause cancer. Their findings, which could lead to new diagnostic markers and cancer treatments with fewer side effects, will appear in two reports in the May 21 advanced online version of the journal Nature.

The studies, led by Tatiana Kutateladze, PhD, an assistant professor in the UCDHSC Department of Pharmacology, and Or Gozani, MD, PhD, an assistant professor in the Department of Biological Sciences at Stanford University, revealed the significance of a novel function of the recently discovered tumor-suppressive molecule, which is thought to inhibit cancer formation and growth. These findings highlight a new mechanism to regulate gene expression programs that allow for appropriate responses to DNA damage in normal cells. When the process breaks down, such damage and other acute stresses are thought to lead to cancer.

The first study, Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2, was conducted in Kutateladze's laboratory with the assistance of graduate student Pedro Peña and research assistant Foteini Davrazou. Other co-authors include Rui Zhao, PhD, an assistant professor in the UCDHSC Department of Biochemistry and Molecular Genetics; Or Gozani, Xiaobing Shi and Kay L. Walter from Stanford University's Department of Biological Sciences; and Vladislav V. Verkhusha from the Department of Anatomy and Structural Biology at the Albert Einstein College of Medicine in New York.

The paper based on their work describes the structural aspects of the tumor suppressor action, while functional studies were accomplished by Gozani's group, and are the subject of the second report that will appear in Nature titled ING2 PHD domain links histone H3 lysine 4 methylation to active gene repress
'"/>

Source:Stanford University


Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
(Date:12/16/2009)... A University of Maryland School of Medicine researcher will ... nation,s most prominent scientists in the field of stem ... and Preventive Medicine, was chosen by the National Heart, ... of this consortium of national experts, which will be ... center will be funded by a $30 million grant ...
(Date:12/16/2009)... BIO-key International, Inc. (OTC Bulletin ... safety and finger-based biometric identification solutions, announced ... a Special Shareholder Meeting held today approved ... Division to Interact911 Mobile Systems Inc. Of ... favor and 1.2% were opposed. ,, (Logo: ...
(Date:12/16/2009)... European Union (EU) member states are spending ... increasingly subjected to unauthorised immigration and illegal ... security and IT-based systems will boost the ... ) ,, New analysis from Frost & ... Market Assessment - European Union , finds ...
Breaking Biology News(10 mins):University of Maryland School of Medicine receives $30 million to coordinate stem cell consortium 2University of Maryland School of Medicine receives $30 million to coordinate stem cell consortium 3BIO-key(R) Shareholders Overwhelmingly Approve Sale of Law Enforcement Division 2BIO-key(R) Shareholders Overwhelmingly Approve Sale of Law Enforcement Division 3Increased Spending on the EU's External Borders to Drive the Border Security Market, Says Frost & Sullivan 2Increased Spending on the EU's External Borders to Drive the Border Security Market, Says Frost & Sullivan 3Innovative Medical Technology Companies From Around the World Selected to Present Profiles to Industry Leaders 26 Financiers at AdvaMed 2009 57994 1Innovative Medical Technology Companies From Around the World Selected to Present Profiles to Industry Leaders 26 Financiers at AdvaMed 2009 57994 2Innovative Medical Technology Companies From Around the World Selected to Present Profiles to Industry Leaders 26 Financiers at AdvaMed 2009 57994 3Innovative Medical Technology Companies From Around the World Selected to Present Profiles to Industry Leaders 26 Financiers at AdvaMed 2009 57994 4Innovative Medical Technology Companies From Around the World Selected to Present Profiles to Industry Leaders 26 Financiers at AdvaMed 2009 57994 5Healthcare Reform Must Include Full Participation by Licensed Professional Insurance Agents 57991 1Healthcare Reform Must Include Full Participation by Licensed Professional Insurance Agents 57991 2Democratic Governors Urge Congress to Act on Health Insurance Reform 57988 1Democratic Governors Urge Congress to Act on Health Insurance Reform 57988 2
... That Cause Cavities and Gum Disease , Blue ... hydrogen peroxide (H 2 O 2 ) combined may be ... biofilms that can cause cavities and gingivitis. The researchers ... California San Francisco report their findings in the July 2008 ...
... continental shelf and drive carbon capture in the deep ocean, ... finding does not change estimates of the oceans, total carbon ... oceans and major rivers. , The tropical North Atlantic had ... of ocean life. A 2007 study estimated that ocean,s contribution ...
... a second strain of the virus, the two viral ... strain of the virus. It is known that ... leads to a loss of immune control of viral ... Research Center at Massachusetts General Hospital (PARC/MGH) shows that ...
Other Biology News:Tips from the Journals of the American Society for Microbiology 2Tips from the Journals of the American Society for Microbiology 3Amazon powers tropical ocean's carbon sink 2Viral recombination another way HIV fools the immune system 2
(Date:12/16/2009)... , ... Argonne, Ill. (Vocus) ... Energy’s (DOE) Argonne National Laboratory and Northwestern University, Evanston, ... in a solution, providing insights for design of bio-inspired dynamically ... million times more massive than the bacteria,” said physicist and ...
(Date:12/16/2009)... for fiscal 2009; on track for positive cash ... /PRNewswire-FirstCall/ - Microbix Biosystems Inc. (MBX:TSX) a biotechnology ... reported financial results for fourth quarter and full-year ... 2009, Microbix reported revenues of $6.08 million, a ... For fourth-quarter 2009, the Company saw revenues increase ...
(Date:12/16/2009)... Germany, December 16 Eppendorf has ... and Verigene(R) SP systems for,infringement of European ... "Method for the,identification and/or the quantification of ... and all imports of the respective products ... authorities are required to confiscate any,violating products. ...
(Date:12/15/2009)... Department of Energy (DOE) bio-energy research centers, has selected ... intellectual property. , ... ... Surety, LLC , the leading provider of data ... BioEnergy Institute (JBEI), one of three Department of Energy ...
Breaking Biology Technology:Argonne Scientists Use Bacteria to Power Simple Machines 2Argonne Scientists Use Bacteria to Power Simple Machines 3Microbix' Pipeline Set To Reach Milestones In 2010 2Microbix' Pipeline Set To Reach Milestones In 2010 3Microbix' Pipeline Set To Reach Milestones In 2010 4Microbix' Pipeline Set To Reach Milestones In 2010 5Microbix' Pipeline Set To Reach Milestones In 2010 6Microbix' Pipeline Set To Reach Milestones In 2010 7Microbix' Pipeline Set To Reach Milestones In 2010 8Eppendorf Successfully Initiates Import ban Against Nanosphere, Inc. for the Countries of the European Union 2Joint BioEnergy Institute Selects Surety's AbsoluteProof to Protect the Integrity and Legally Defend the Authenticity of its Scientific Intellectual Property 2Joint BioEnergy Institute Selects Surety's AbsoluteProof to Protect the Integrity and Legally Defend the Authenticity of its Scientific Intellectual Property 3Joint BioEnergy Institute Selects Surety's AbsoluteProof to Protect the Integrity and Legally Defend the Authenticity of its Scientific Intellectual Property 4Joint BioEnergy Institute Selects Surety's AbsoluteProof to Protect the Integrity and Legally Defend the Authenticity of its Scientific Intellectual Property 5
... 5 /PRNewswire-FirstCall/ - YM BioSciences Inc.,(AMEX: YMI ... that identifies,develops and commercializes differentiated products for patients ... David Allan, Chairman and CEO, at,12:00pm EDT today, ... are invited to discuss the preliminary results obtained ...
... -- Record consolidated revenues of $14.9 million -- ... of $2.3 million - 49% growth ... million credit facility - expands capital resources, -- Reported MIS procedure times of 60 minutes and ... days ...
... MONTREAL, Aug. 5 /PRNewswire-FirstCall/ - ProMetic Life ... has reached an understanding,with a fully integrated, ... and global commercialization of several biopharmaceutical,products in ... to licensing, development and milestone fees as ...
Other Biology Technology:NOTICE OF YM BIOSCIENCES CONFERENCE CALL TO DISCUSS PHASE II DATA FOR NIMOTUZUMAB IN METASTATIC COLORECTAL CANCER 2AtriCure Reports Record Second Quarter 2008 Financial Results 2AtriCure Reports Record Second Quarter 2008 Financial Results 3AtriCure Reports Record Second Quarter 2008 Financial Results 4AtriCure Reports Record Second Quarter 2008 Financial Results 5AtriCure Reports Record Second Quarter 2008 Financial Results 6AtriCure Reports Record Second Quarter 2008 Financial Results 7AtriCure Reports Record Second Quarter 2008 Financial Results 8Prometic reaches understanding for commercialisation of several biopharmaceutical products and strategic investment 2Prometic reaches understanding for commercialisation of several biopharmaceutical products and strategic investment 3
... StabilGuard Biomolecule Stabilizer is a bovine protein-free ... is an aqueous solution that contains non-toxic ... saline), pH 6.6 - 7.2, and does ... maintains the activity of antibodies and other ...
... The lyophilization stabilizer is designed ... process and for long-term storage. ... toxic ingredients. It is a ... pH 7.2, and is superior to ...
... The CERTOMAT IS, a true benchtop incubator-shaker, ... shakers. Having a footprint of 540 x ... a large incubation chamber (370 x 505 x ... orbits, the CERTOMAT IS is ideal for shaking ...
... smallest thermal cyclers on the market, which is ... (20 samples) or 0.2ml microtube (25 samples) block ... cooling rate of 3.6C/sec and 2.0C/sec respectively ... track programming with new quick dial facility ...
Biology Products: