Navigation Links
Researchers trace evolution to relatively simple genetic changes

tic variant in the marine population."

So, he said, "the marine fish actually carry the genes for this alternative state, but at such a low level it is never seen;" all the ocean fish remain well-armored. "But they do have this silent gene that allows this alternative form to emerge if the fish colonize a new freshwater location."

Also, comparing what happens to the ectodysplasin signaling molecule when its gene is mutated in humans, and in fish, shows a major difference. The human protein suffers "a huge amount of molecular lesions, including deletions, mutations, many types of lesions that would inactivate the protein," Kingsley said.

But in contrast, "in the fish we don't see any mutations that would clearly destroy the protein." There are some very minor changes in many populations, but these changes do not affect key parts of the molecule. In addition, one population in Japan used the same gene to evolve low armor, but has no changes at all in the protein coding region. Instead, Kingsley said, "the mutations that we have found are, we think, in the (gene's) control regions, which turns the gene on and off on cue." So it seems that evolution of the fish is based on how the Eda gene is used; how, when and where it is activated during embryonic growth.

Also, to be sure they're working with the correct gene, the research team used genetic engineering techniques to insert the armor-controlling gene into fish "that are normally missing their armor plates. And that puts the plates back on the sides of the fish," Kingsley said.

"So, this is one of the first cases in vertebrates where it's been possible to track down the genetic mechanism that controls a dramatic change in skeletal pattern, a change that occurs naturally in the wild," he noted.

"And it turns out that the mechanisms are surprisingly simple. Instead of killing the protein (with mutations), you merely adjust the way it is normally regulated. That allows you t
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3 4 5

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers add new tool to tumor-treatment arsenal
9. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
10. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
11. Researchers develop rapid diagnostic tool for pathogen identification
Post Your Comments:
(Date:4/17/2014)... Gene expression is the process whereby the genetic ... products, such as proteins, which have numerous different ... as an important intermediary during gene expression, by ... molecular mechanisms involved in manufacturing proteins. , ... mRNA molecules present in an organism at a ...
(Date:4/17/2014)... are chock full of wild animals and plant life, ... fungi are churning away in the soil, decomposing organic ... the vital role these fungi play in ecological systems, ... team of scientists has generated a genetic map of ... The work was published this week in the ...
(Date:4/17/2014)... by the Australian National University (ANU), have developed ... deep-sea temperature variability over the past 5.3 million ... the climate surrounding ice ages over the past ... relationship between carbon dioxide levels, global temperatures and ... of Southampton (UoS) and the National Oceanography Centre ...
Breaking Biology News(10 mins):Rapid and accurate mRNA detection in plant tissues 2Stanford biologists help solve fungal mysteries 2Stanford biologists help solve fungal mysteries 3Ancient sea-levels give new clues on ice ages 2
... from the crops of parent birds, is rare among birds ... male emperor penguins. Essential for the growth and development of ... parents from fluid-filled cells lining the crop that are rich ... access journal BMC Genomics uses new technology to study the ...
... PROVIDENCE, R.I. [Brown University] It,s been long known ... cells stabbed with spiky, long asbestos fibers, and the image ... cell, like a quivering arrow that,s found its mark. ... be interested in asbestos fibers and other materials at the ...
... ITHACA, N.Y. With an eye toward understanding DNA replication, ... actually unzip the two strands of DNA. (Nature, online Sept. ... including DNA replication, are enzymes called helicases. Acting like motors, ... the strands to "zip" apart. What had been a ...
Cached Biology News:Milking the pigeon: extracting the mechanisms involved 2Why carbon nanotubes spell trouble for cells 2For unzipping DNA mysteries -- literally -- Cornell physicists discover how a vital enzyme works 2
(Date:1/14/2014)... 14, 2014 Carahsoft and CDS Federal ... 23, 2014 at 2pm EST (11am PST), “Natural Language ... focuses on how technology can turn raw, heterogeneous data ... government agencies. The online webinar will last approximately one ...
(Date:1/14/2014)... Texas , Jan. 14, 2014 The ... and research medicinal plants and therapeutic derivatives thereof ... health professionals, and researchers about the challenges of ... http://photos.prnewswire.com/prnh/20100430/DC95601LOGO ) The Society ...
(Date:1/14/2014)... Global Record Systems, LLC, (GRS), ... solutions for patients, physicians, the biopharmaceutical industry, regulators, ... the signing of a three-year Research Collaboration Agreement ... (FDA). This initiative is designed to generate ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Independent publisher ... California, and Montreal, Canada, has big ideas for 2014 ... The press's goals are to produce high-quality, low-cost, DRM-free ... support local businesses. , The first major development ...
Breaking Biology Technology:Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2Bitingduck Press Looks Forward to 2014 With Multimedia E-books 2
... bit proprietary about the companies that have launched products at the ... always sorry when a company hits the bumps that inevitably pock ... so many of my "children" see the rewards for their very ... on the fund-raising circuit. Jingle Networks (DEMOfall 05) has ...
... Milwaukee Journal Communications, Inc. has ... , its telecommunications subsidiary, to shareholders. The transaction could ... spin-off will be completed through a pro-rata distribution of ... Smith, chairman and chief executive officer of Journal Communications, ...
... One of the more hopeful promises of stem cells is ... that is not being met by organ donation. But experts expressed ... lead to backlash: among patients if cures do not materialize, and ... transplants are just one way that stem cells could be used ...
Cached Biology Technology:A windfall of funds for DEMO companies 2A windfall of funds for DEMO companies 3Journal Communications to spin off Norlight 2Stem cells raise hopes, but is there money in them? 2Stem cells raise hopes, but is there money in them? 3