Navigation Links
Researchers to develop active nanoscale surfaces for biological separations

A team of researchers has received a four-year, $1 million grant from the National Science Foundation to study improved methods for biological separations. Led by Ravi Kane, the Merck Associate Professor of Chemical and Biological Engineering at Rensselaer Polytechnic Institute, the group plans to develop nanoscale surfaces that actively reassemble in the presence of DNA, which could eventually lead to more efficient separation tools for genomics and proteomics.

The researchers are taking their inspiration from nature, mimicking the very membranes that surround our cells to create platforms for separating biological molecules. These "lipid bilayers," which are made up of two opposing layers of fat molecules, act as the cell's barrier to the outside world. DNA molecules move on these surfaces in two dimensions, much like objects on a conveyor belt. Kane and his colleagues recently discovered that the mobility of DNA molecules is closely coupled to the movement of the underlying lipid bilayer.

"The advantage of these surfaces is that they can be actively modified," Kane said. "Thus by changing the temperature, shining light, or applying an electric field, we propose to change the behavior of the surfaces." In one approach, Kane and his colleagues are building a molecular obstacle course made up of nanoscale domains. When an electric field is applied at one end, DNA molecules will move across the surface and collide with the obstacles, impeding their motion. The researchers have already made surfaces on which they can control the size and positioning of obstacles; next, they plan to test the movement of DNA.

The overarching goal is to understand how biological molecules of all types move across the surface of lipid bilayers. "This particular project is focused on DNA, but the approach could potentially be used for separating other biological molecules, such as proteins," Kane said. He envisions immediate applications in genomics and proteomic
'"/>

Source:Rensselaer Polytechnic Institute


Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
(Date:7/31/2014)... BOZEMAN, Mont. In the same week that the ... dangers of skin cancer, researchers at Montana State University ... the genetic code in every cell responds ... advance fundamental understanding of DNA damage by the UV ... skin cancer, aging and some degenerative eye diseases. ...
(Date:7/31/2014)... familiar with Hibiscus flowers- they are an iconic ... commonly planted in the landscape. Some, like Hawaii,s ... species. , Only a relatively few botanists and ... equally beautiful and intriguing related group of plants ... Hibiscus". , Brother of Hibiscus species are in ...
(Date:7/31/2014)... SPRINGS, Florida , July 31, 2014 ... to develop unique and innovative smart technologies; companies turn ... (NASDAQ: EBAY ), Amazon.com Inc. (NASDAQ: ... ), Google Inc. (NASDAQ: GOOG ) and ... biometric authentication company focused on the growing m-commerce market, ...
Breaking Biology News(10 mins):New paper describes how DNA avoids damage from UV light 2New paper describes how DNA avoids damage from UV light 3Brother of Hibiscus is found alive and well on Maui 2Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 2Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 3Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 4Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 5Smart Technology Consumer's Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet 6
... the color of ocean waters could have a drastic effect on ... such a change in one region of the North Pacific, the ... be a big drop for a region that accounts for more ... that the formation of typhoons as hurricanes are known in ...
... 13, 2010 -- Ben-Gurion University of the Negev,s (BGU) Dr. ... and Environmental Research Center (BERC) in Nablus received a significant ... the Middle East. This study brings together Israelis and Palestinians ... of Nablus over a five-year period. ...
... RICHLAND, Washington -- A little wax and soap can ... to a study in August 11 issue of ... developers to explore lower-priced alternatives to the lithium ion-metal ... a medium in which to grow good electrode materials," ...
Cached Biology News:Ocean's color affects hurricane paths 2Ocean's color affects hurricane paths 3Wax, soap clean up obstacles to better batteries 2Wax, soap clean up obstacles to better batteries 3Wax, soap clean up obstacles to better batteries 4
(Date:7/31/2014)... (PRWEB) July 31, 2014 Held at ... patients with an overview of the disease and its ... drug side effects, as well as updates on the ... to Dr. Sandy Srinivas for organizing this educational opportunity,” ... kidney cancer. “Sandy and her colleagues have put together ...
(Date:7/31/2014)... Canada (PRWEB) July 31, 2014 ... some of the first transcriptome-wide analyses appearing around ... standard assay for RNA measurement. In the last ... throughput, more specific, work with smaller input amounts, ... tissues (eg, blood samples). On the bioinformatics side, ...
(Date:7/31/2014)... Boston, MA (PRWEB) July 31, 2014 ... communication (UC) and collaboration company, is proud to ... System (LMS). LMS complements Adobe Connect’s elearning tools ... curriculums. LMS delivers content with training tools for ... for eLearning with LMS is the perfect online ...
(Date:7/31/2014)... Sales Horizons, a leader in sales training, ... course – Mastering the Complex Sale – ... from proven sales training programs used by thousands of ... online sales training course is available to every salesperson ... with customers, like technical support, engineers, clinical support, and ...
Breaking Biology Technology:The Evolution of RNA-Sequencing, Upcoming Live Webinar August 22 hosted by Xtalks 2SoundConnect Enhances Portfolio with Adobe Connect Learning Management System (LMS) 2Sales Horizons Offers Mastering the Complex Sale - a Comprehensive, Online Sales Skills Training Course 2Sales Horizons Offers Mastering the Complex Sale - a Comprehensive, Online Sales Skills Training Course 3
... Cord Blood America, Inc . (OTC BB: CBAI, CBAID) announced ... 80 percent of its shareholders voting in a recent proxy vote, ... The one for one hundred reverse split reduces the ... A "D" will be placed on the ticker symbol ...
... BALTIMORE, May 6, 2011 Stenting is safe and ... venous stenosis in patients with deep vein thrombosis (DVT), ... Late-Breaking Clinical Trial at the Society for Cardiovascular Angiography ... EVISTA-DVT focused on patients with blocked veins ...
... Halozyme Therapeutics, Inc. (Nasdaq: HALO ), ... extracellular matrix for the diabetes, cancer, dermatology ... the first quarter 2011. (Logo: http://photos.prnewswire.com/prnh/20100302/LA63139LOGO ... duration of action observed in our first ultrafast insulin ...
Cached Biology Technology:Study Shows Stents Are Superior to Balloons Alone for Patients With Deep Venous Thrombosis 2Halozyme Therapeutics Reports First Quarter 2011 Financial Results 2Halozyme Therapeutics Reports First Quarter 2011 Financial Results 3Halozyme Therapeutics Reports First Quarter 2011 Financial Results 4Halozyme Therapeutics Reports First Quarter 2011 Financial Results 5Halozyme Therapeutics Reports First Quarter 2011 Financial Results 6
...
Mouse monoclonal [2G1] to Vancomycin ( Abpromise for all tested applications)....
Rab1A...
... ( Abpromise for all tested ... Synthetic peptide: DWLCL AFVE SKFNISKINE NADGSFDYGL ... amino acids 46-100 of Human LYZL6 ... 57151 Swiss ...
Biology Products: