Navigation Links
Researchers to develop active nanoscale surfaces for biological separations

A team of researchers has received a four-year, $1 million grant from the National Science Foundation to study improved methods for biological separations. Led by Ravi Kane, the Merck Associate Professor of Chemical and Biological Engineering at Rensselaer Polytechnic Institute, the group plans to develop nanoscale surfaces that actively reassemble in the presence of DNA, which could eventually lead to more efficient separation tools for genomics and proteomics.

The researchers are taking their inspiration from nature, mimicking the very membranes that surround our cells to create platforms for separating biological molecules. These "lipid bilayers," which are made up of two opposing layers of fat molecules, act as the cell's barrier to the outside world. DNA molecules move on these surfaces in two dimensions, much like objects on a conveyor belt. Kane and his colleagues recently discovered that the mobility of DNA molecules is closely coupled to the movement of the underlying lipid bilayer.

"The advantage of these surfaces is that they can be actively modified," Kane said. "Thus by changing the temperature, shining light, or applying an electric field, we propose to change the behavior of the surfaces." In one approach, Kane and his colleagues are building a molecular obstacle course made up of nanoscale domains. When an electric field is applied at one end, DNA molecules will move across the surface and collide with the obstacles, impeding their motion. The researchers have already made surfaces on which they can control the size and positioning of obstacles; next, they plan to test the movement of DNA.

The overarching goal is to understand how biological molecules of all types move across the surface of lipid bilayers. "This particular project is focused on DNA, but the approach could potentially be used for separating other biological molecules, such as proteins," Kane said. He envisions immediate applications in genomics and proteomic
'"/>

Source:Rensselaer Polytechnic Institute


Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
(Date:10/31/2014)... the world,s largest producer of cocoa. Chocolate trees ( ... ha region of rainforest in the state of Bahia, ... the surrounding rainforest was a biodiversity hotspot, the chocolate ... seeds introduced in the mid 1700s, had very low ... Pereira, "This scenario created a very romantic, but extremely ...
(Date:10/31/2014)... the air out of a nagging mystery about the development ... as to why animal species didn,t flourish sooner, once sufficient ... the end of the Proterozoic period, about 800 million years ... when most researchers think there also was plenty of oxygen? ... after all. , In a study published Oct. 30 in ...
(Date:10/31/2014)... the war against Ebola one important hurdle has just ... at the University of North Carolina at Chapel Hill ... mice that can be infected with Ebola and display ... published in the current issue of Science , ... vaccines, which are desperately needed to curb the worldwide ...
Breaking Biology News(10 mins):Scientists seek cure for devastating witches' broom disease of the chocolate tree 2Scientists seek cure for devastating witches' broom disease of the chocolate tree 3Lack of oxygen delayed the rise of animals on Earth 2Improved mouse model will accelerate research on potential Ebola vaccines, treatments 2
... a nanomedicine milestone today as they announced the creation ... forms a partnership between university researchers and an international ... treatment created at MU. Shasun Pharmaceuticals Ltd., one ... new company in partnership with MU nanomedicine experts Kattesh ...
... international effort, on the scale of the Human Genome ... cancer cells. HGP was the international scientific research project ... Within a decade, they believe, results of the new ... customized to their own biology. The perspective appears in ...
... sharks may be too weak to capture and kill large marine ... Biomechanics by an international team of scientists. , The researchers also ... matter how widely their jaws are open, thanks to a unique ... most successful predators of all time. , The study is the ...
Cached Biology News:MU cancer scientists form new company with international pharmaceutical firm 2MU cancer scientists form new company with international pharmaceutical firm 3Teenage great white sharks are awkward biters 2
(Date:10/31/2014)... Having access to safe drinking water ... in many corners of the globe. It’s a major ... northwestern Bolivia where many have been sickened by unclean ... University’s School of Engineering has been working to improve ... “the united college for the peasants.” A branch university ...
(Date:10/31/2014)... Edwardsville, Ill. (PRWEB) October 31, 2014 ... Edwardsville’s Department of Historical Studies within the College of ... at SIUE to record the history of alcohol-based fuels ... politicians, and many others have been working to build ... an important but overlooked aspect of the state's agricultural ...
(Date:10/31/2014)... 31, 2014 Brady (NYSE:BRC), ... today announced a new video testimonial on ... the video, a research technician at the BloodCenter of ... to labeling and storing hundreds of thousands of samples, ... her research. , “At Brady, we design our label ...
(Date:10/31/2014)... -- Atlanta-based Intellimedix could make a positive contribution to ... by suggesting a new, computational approach for investigating ... Computational Systems Biology have spent years developing computer ... existing drugs through systematic repurposing, and their technology ... Ebola. Logo - http://photos.prnewswire.com/prnh/20141030/155702LOGO ...
Breaking Biology Technology:Fairfield University School of Engineering project reduces illness in rural community 2Fairfield University School of Engineering project reduces illness in rural community 3SIUE History Prof Manuel Working on Biofuels Book with NCERC 2SIUE History Prof Manuel Working on Biofuels Book with NCERC 3Brady Debuts New Lab Label Testimonial Video 2Atlanta-Based Intellimedix May Help Solve Ebola With Computer Algorithms 2
... ... of the National Institutes of Health (NIH), awarded a $2.18 million grant to Aciont Inc. ... , ... City, UT (PRWEB) December 10, 2009 -- The National Eye Institute (NEI), a division of ...
... , , ... TAI,AN, China, Dec. 10 /PRNewswire-Asia-FirstCall/ -- China Biologic,Products, Inc. (Nasdaq: ... biopharmaceutical companies in China, today announced,that the Company,s senior management team ... City at 9:30 a.m. ET on Tuesday, December 15,2009. , ...
... SEATTLE, Dec. 10 Dendreon Corporation (Nasdaq: DNDN ) ... chief operating officer, effective January 4, 2010. Mr. Bishop ... at Bayer, where he was responsible for a diverse portfolio ... served as an executive vice president of Bayer HealthCare LLC. ...
Cached Biology Technology:NEI Awards a Two-Year $2.18 Million SBIR Grant to Aciont 2NEI Awards a Two-Year $2.18 Million SBIR Grant to Aciont 3China Biologic Products to Ring NASDAQ Opening Bell 2China Biologic Products to Ring NASDAQ Opening Bell 3Dendreon Appoints Hans Bishop as Chief Operating Officer 2
... Fiberboard boxes are ideal for use in refrigerators, freezers, ... racks. Four vibrant colors allow for color coding to ... liquid nitrogen drainage or promote cool air circulation. Supplied ... holds 81 tubes. Box dimensions: 13 x ...
Sterile glass 5 mm beads that make spreading bacterial and yeast cultures easy. Can be washed, autoclaved and reused....
Similar to proteasome (prosome, macropain) 26S subunit, ATPase, 1 Antigen: Recombinant Protein...
RABBIT ANTI AMPHOTERIN...
Biology Products: