Navigation Links
Researchers test new therapy for advanced melanoma

Melanoma is a particularly deadly form of skin cancer very resistant to treatment. Researchers at H. Lee Moffitt Cancer Center & Research Institute and the University of South Florida are testing a promising new therapy that prompts the immune system to aid in the fight against melanoma tumors.

"This is a milestone clinical trial because it is the first time that electroporation is being used to deliver plasmid DNA in a gene therapy study in humans," said Richard Heller, PhD, USF professor of medical microbiology and immunology who helped develop the technology used in the study.

Electroporation is a technique in which a hand-held device applied to the skin delivers pulses of electricity to open up pores in the tumor cell membrane. This opening allows a small therapeutic molecule -- in this case a molecule known as a DNA plasmid that contains the gene for Interleukin-12 -- to slip inside the melanoma tumor before the membrane reseals.

"Melanoma does not respond well to standard chemotherapy," said Adil Daud, MD, assistant professor of oncology in the Cutaneous Oncology Program at Moffitt. "Gene therapy gives us the flexibility to introduce a huge variety of potential targets for treatment, but its major limitation has been getting the gene into the cancer. If electroporation can deliver the gene to these tumors reliably and without serious side effects, melanoma and other cancers would be open to many new treatment possibilities."

Six years of laboratory studies by Dr. Heller and his colleagues preceded the initial human trial begun earlier this year at Moffitt. The collaboration of USF and Moffitt in this trial is a good example of translational research -- moving the new application of a gene transfer technology from an animal model to the patient. Dr. Heller's team worked extensively with Dr. Daud to adapt the electroporation technique used on mice to humans.

The researchers injected the DNA plasmid, which encodes a gene
'"/>

Source:University of South Florida Health Sciences Center


Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researchers test new therapy for advanced melanoma

(Date:7/23/2014)... 15-year analysis of the movements of satellite-tagged blue whales ... that their favored feeding areas are bisected by heavily ... mortality. , The researchers note that moving the shipping ... different areas at least, during summer and fall ... decrease the probability of ships striking the whales. A ...
(Date:7/23/2014)... Migratory songbirds are disappearing, and though conservationists are examining ... habitat, acid rain and light pollution, a key piece ... birds go once they leave their breeding sites, and ... , To answer this question, a team of researchers ... migratory connectivity map produced for a songbird, using tracking ...
(Date:7/23/2014)... is commonly found in dead bodies and is used ... referred to as the post mortem interval. A report ... from Tamil Nadu is provided for the first time ... of DNA barcoding. This study, significant in forensic investigations ... Journal . , Chrysomya megacephala is commonly ...
Breaking Biology News(10 mins):15-year analysis of blue whale range off California finds conflict with shipping lanes 215-year analysis of blue whale range off California finds conflict with shipping lanes 315-year analysis of blue whale range off California finds conflict with shipping lanes 4York University researchers use bird 'backpacks' to put wood thrushes migration on the map 2Dead body feeding larvae useful in forensic investigations 2
... combined genetic and geographic data of the H5N1 avian ... decade. They found that multiple strains of the virus ... identified many of the migration routes through which the ... H5N1 strains develop and migrate, health officials can better ...
... brewing about whether pre-Columbian Amazonian populations settled in large ... that many conservationists take to be ‘natural.' , This ... and is challenged in a recent paper from Dr. ... findings of Bush’s research may rekindle a debate has ...
... genes from an ancient wheat variety have led to a ... recent set of papers published in the journal Plant Physiology ... Nax2. The genes work by excluding salt from different parts ... the leaves. The discovery of the two genes is the ...
Cached Biology News:UCI scientists reconstruct migration of avian flu virus 2Paper challenges 1491 Amazonian population theories 2Paper challenges 1491 Amazonian population theories 3Paper challenges 1491 Amazonian population theories 4Ancient genes used to produce salt-tolerant wheat 2
(Date:7/22/2014)... July 21, 2014 (PRWEB) July 23, 2014 ... at Rutgers University. , The goal of ... across the full spectrum of scientists working in ... and development topics that represent the most promising ... programmed to:,     Provide faculty and ...
(Date:7/22/2014)... solution of rod-shaped metal nanoparticles in water with ultrasound ... drill bits. Why? No one yet knows exactly. But ... (NIST) have clocked their speedand it,s fast. At up ... times faster than any nanoscale object submerged in liquid ... has opened up the possibility that they could be ...
(Date:7/22/2014)... CTD Holdings, Inc. (OTCQB:CTDH), a manufacturer ... cosmetics, and other markets, announced today that it has ... qualified private investors led by Novit L.P., an investment ... transaction involved the signing of a Securities Purchase Agreement ... Stock at a price per share of $1.00, resulting ...
(Date:7/22/2014)... Two new members were elected to the University ... Shareholders Meeting on June 13: Kerry R. Benson, Managing ... and Stephen T. Zarrilli, President and CEO of Safeguard ... Michael A. DiPiano, Managing General Partner of New Spring ... Esq., of Duane Morris LLP, as Director Emeritus. , ...
Breaking Biology Technology:The 2014 NJ Symposium on Biomaterials Science Earns Society for Biomaterials Endorsement 2NIST shows ultrasonically propelled nanorods spin dizzyingly fast 2CTD Holdings Closes $1.725 Million Private Placement 2CTD Holdings Closes $1.725 Million Private Placement 3Two New Members Elected to University City Science Center Board of Directors 2Two New Members Elected to University City Science Center Board of Directors 3
... Thursday, the 17th annual SBIR/STTR Conference will be held ... the Crowne Plaza in Madison, 4402 E. Washington. The ... Innovation Research (SBIR) and Small Business Technology Transfer (STTR) ... federal dollars available to small businesses for technological innovation. ...
... Software, worldwide leader in e-document ... Fax and VSI-FAX(R) product families, ... 3.0. This new solution allows ... more efficiently, effectively, and economically ...
... Biosciences, Inc. announced today that it has developed a ... The test is now in the hands of USAMRIID (US ... shipped to WHO Central Public Health Laboratory (UK) and the ... sequencing of the SARS genome, EraGen went to work immediately ...
Cached Biology Technology:Annual Conference Honors Tech Grant Winners 2EraGen Biosciences Ships SARS Diagnostic Test in Record Time 2
Request Info...
Services include subcloning into an expression vector. Tagged protein will be expressed in small scale for testing yield and solubility and then in 1L culture for large scale affinity purification. E...
Request Info...
...
Biology Products: