Navigation Links
Researchers show key protein necessary for normal development of red blood cells

Virginia Commonwealth University researchers studying hemoglobin genes, mutations of which play a role in genetic blood disorders like sickle cell anemia and beta-thalassemia, have shown in studies with mice that the KLF2 protein is crucial for making young red blood cells.

The findings may point researchers to future gene therapies for patients with sickle cell anemia and beta-thalassemia.

In the October issue of Blood, the journal of the American Association for Hematology, researchers demonstrated that a protein called KLF2 regulates the production of embryonic globin genes and the maturation and stability of embryonic red blood cells in a mouse model. Researchers observed that KLF2 is responsible for controlling and "turning on" the embryonic globin gene.

"Understanding how genes are turned on and off, and the switch from the embryonic globin gene to the adult beta-globin gene has clinical relevance to treatment of sickle cell anemia and beta-thalassemia," said Joyce A. Lloyd, Ph.D., associate professor of Human Genetics at VCU, and corresponding author for this study.

"Our findings are significant for future treatment of these blood disorders, potentially using gene therapies and other novel strategies," she said. In gene therapy, a normal DNA is inserted into cells to correct a genetic defect. To correct the defect or mutation, a gene may be replaced, altered or supplemented.

According to Lloyd, the production of blood cells involves a complex differentiation pathway that involves the interaction of many molecular players and proteins.

In humans, there are four globin genes clustered on chromosome 11 in the order in which they are "turned on" or expressed. These genes include the epsilon-globin gene, two gamma-globin genes and the beta-globin gene. Lloyd said that during fetal development, the embryonic epsilon-globin gene is active first, followed by the gamma-globin genes, and finally the adult form, beta-glo
'"/>

Source:Virginia Commonwealth University


Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
(Date:3/11/2015)... March 11, 2015   The Sync Project™ ... to scientifically measure and harness music to improve ... biometrics and objective measurements of physiology, enabling the ... scale in large populations. It is designed for ... clinicians perform rigorous studies and accelerate the discovery ...
(Date:3/10/2015)... , March 10, 2015  NXT-ID, Inc. ... or the "Company"), a biometric authentication company focused ... company,s Wocket™ smart wallet has been named the ... Rethink Modern. Rethink Modern ( http://www.rethinkmodern.com/ ... innovative items for your home and lifestyle that have a ...
(Date:3/2/2015)... , March 2, 2015 Synaptics ... developer of human interface solutions, today announced a ... is designed to enable rapid and secure transactions ... module for gaming is a turnkey solution providing ... ability to quickly integrate fingerprint ID solutions into ...
Breaking Biology News(10 mins):Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 2Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 3NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 3NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 4Synaptics Unveils New Fingerprint ID Solution for Gamers 2Synaptics Unveils New Fingerprint ID Solution for Gamers 3
... DALLAS Nov. 15, 2010 Tiny molecules called ... of labor, raising the prospect that RNA-based drugs might ... Southwestern Medical Center have discovered in a preclinical study. ... that controls labor, so with future research we might ...
... in curing ovarian cancer but new research from the Centenary ... in a new way that can break the resistance mechanism. ... the drug (FTY720) had a potent effect in human ovarian ... commonly used chemotherapeutic drug currently available for the treatment of ...
... Rice University scientists have found a way to predict rapidly ... included in the annual seasonal flu vaccine. While it sometimes ... dominant worldwide, the new method can predict whether they will ... first appears in the GenBank database, the National Institutes of ...
Cached Biology News:Tiny RNA molecules control labor, may be key to blocking premature birth 2New treatment to overpower drug resistance in ovarian cancer 2New way of predicting dominant seasonal flu strain 2New way of predicting dominant seasonal flu strain 3
(Date:3/30/2015)... -- Richmond Pharmacology nimmt weltweit den ... das erste Zentrum weltweit, das in Zusammenarbeit mit ... London in einer weltweiten ... einem Patienten begonnen hat. Das Therapeutikum wurde für ... einer seltenen Herz- und Nervenkrankheit. ...
(Date:3/29/2015)... Texas , March 29, 2015 /PRNewswire/ ... presentation of important study data showing the ... in 1,599 gynecologic cancer samples. Using Caris ... profiling service, researchers identified expression of programmed ... cancers independent of histology while its ligand ...
(Date:3/27/2015)... 27. März 2015  Peter Walter wurde ... Science für seine bahnbrechende Arbeit ausgewählt, die ... transportiert werden, sowie für die Entschlüsselung der ... auf Stress nutzen, der mit der Ansammlung ... Professor für Biochemie an der University of ...
(Date:3/27/2015)... LONDON , March 27, 2015 ... Royal Free Hospital in London , Richmond ... for a global Phase 3 study for an investigational RNAi ... an orphan disease affecting the nerves and heart. ... Record Detail Based at St Georges University ...
Breaking Biology Technology:Caris Life Sciences' Multiplatform Tumor Profiling Technology Identifies Expression of PD-1 and PD-L1 in Gynecologic Malignancies 2Caris Life Sciences' Multiplatform Tumor Profiling Technology Identifies Expression of PD-1 and PD-L1 in Gynecologic Malignancies 3Caris Life Sciences' Multiplatform Tumor Profiling Technology Identifies Expression of PD-1 and PD-L1 in Gynecologic Malignancies 4Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 2Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 3Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 4
... , THOROLD, ON , ... innovative privately held Canadian biotechnology company focusing primarily on ... purification, today announced the launch of 10 new kits ... from blood, plasma and serum, including circulating nucleic acids. ...
... , Collaboration will further evaluate novel stem cell-derived ... genes relevant to disease progression , CAMBRIDGE, Mass. ... California Stem Cell, Inc. (CSC) and ALS Therapy Development ... expansion of their collaboration aimed at advancing a potential stem ...
... SANTA ROSA, Calif. , Feb. 2 Just in ... introduces the newest in their scientifically formulated product line: CIRCUTOL™ Cardiovascular ... in 1995 by integrative medicine pioneer, Dr. Isaac Eliaz ... being at the forefront of the latest developments in natural alternative health ...
Cached Biology Technology:Norgen Biotek Launches 10 New Kits for the Isolation of High-Quality Circulating Nucleic Acids from Blood, Plasma and Serum 2California Stem Cell and ALS Therapy Development Institute Extend Their Collaboration to Advance Potential Stem Cell Assisted Therapy for ALS 2California Stem Cell and ALS Therapy Development Institute Extend Their Collaboration to Advance Potential Stem Cell Assisted Therapy for ALS 3California Stem Cell and ALS Therapy Development Institute Extend Their Collaboration to Advance Potential Stem Cell Assisted Therapy for ALS 4Just in Time for Heart Health Month... TRIPLE Cardiovascular Health Support From EcoNugenics 2Just in Time for Heart Health Month... TRIPLE Cardiovascular Health Support From EcoNugenics 3
... Ultra low freezers ... the most critical material storage, Ultima II ... anywhere. Available in general purpose and blood ... the Revco IntrLogic microprocessor control system with ...
... SkanIt™ Software is the ultimate tool ... data handling. There are two editions ... Edition for scientists working in life ... Edition offering features needed for compliance ...
...
Thermo Labsystems offers a basic reader for 96-well microplates that is especially adapted for ELISA and other colorimetric assays....
Biology Products: