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Researchers seek to discover what really happens when a virus enters the body

roscopy ?also estimates and corrects the effect of the microscope's uneven illumination and the markers' spectral overlap," Bell explains.

As Bell and Duca are able to develop their composite images, they will be able to mathematically produce a quantitative description of the spreading of the virus as well as the host-virus interaction. "The immuno-fluorescent intensity signals (IIS) depict how the virus and host are interacting over time, from the point of origin to the point of infection," Bell says.

Ultimately, the interdisciplinary team hopes their efforts will provide a quantitative method that derives a characteristic profile or fingerprint from the IIS of any host-virus system. If their method can achieve results in hours instead of days, their techniques could be used in clinical and field settings to quickly identify known viruses, or to map unknown viruses to existing profiles to better predict their behavior and start appropriate treatment.

Ultimately, their work should contribute to what starts an immune response. And as NIH's Matzinger says, knowing what initiates an immune response will affect and, researchers hope, improve medical treatment.

Bell is an associate member of the Virginia Tech ?Wake Forest University's School of Medicine School of Biomedical Engineering and Science. SBES research focuses on imaging and medical physics, as well as biomechanics and cell and tissue engineering. Imaging has the invaluable potential to greatly extend the reach of medical research beyond detecting the anatomical presence of the disease. Employing applied engineering technologies to treatment will allow more intensive study of diseases at the cellular level. A greater understanding of the physiology of an illness will lead to more targeted treatments.


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Source:Virginia Tech


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