Navigation Links
Researchers quantify more noise in gene expression

recent division, and the phenotypes of these two otherwise identical cells can be very different."

Macroscopic variations are routinely observed in the genetically identical cells of organisms ranging in complexity from bacteria to mammals. "Watchmakers can neither make individual watches with intrinsically perfect accuracy, nor perfectly synchronize any two watches to eliminate extrinsic variations," said Hasty. "And intrinsic and extrinsic variation in gene expression also prevents genetically identical cells growing side-by-side from ticking in unison."

Intrinsic noise resulting from low copy numbers of molecules has been the focus of earlier studies by Hasty's group. Its Nature paper focuses on extrinsic noise, an even larger source of variation between identical cells growing side-by-side in identical conditions. "This extrinsic noise originates from cells being out of phase in their growth cycle," said Hasty. "It's unavoidable. This study also established an 'extrinsic-noise floor' in 11 genes for which intrinsic noise is negligible."

The group measured the noise floor by used genetically engineered strains of yeast with a green fluorescence marker linked to a gene involved in the metabolism of the sugar galactose. The galactose gene and 10 others were chosen because they are expressed in yeast cells in high copy numbers, a feature that makes intrinsic noise in their expression statistically insignificant. By making cell-to-cell comparisons of the activation of the galactose-fluorescence gene pair in experiments with one to five copies of the gene pair per cell, the team was able to measure the extrinsic-noise floor, a parameter that is needed to create a mathematical algorithm describing gene-expression variation in yeast.

"This may sound relatively straightforward: extrinsic variability is due to individual cells growing out of phase with one another," said Hasty. "However, this study is the first rigorous description of this
'"/>

Source:University of California - San Diego


Page: 1 2 3

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researchers quantify more noise gene expression

(Date:10/2/2014)... , October 1, 2014 CARTES ... Major Trends in the Sector CARTES SECURE CONNEXIONS ... Centre from 4 to 6 November 2014. This 29 ... to payment, identification and mobility, will bring together the ... this year, a rich programme of conferences will set ...
(Date:10/1/2014)... , October 1, 2014 ... in the life science field  The ... come and go over the years. Some are ... Photon upconversion is a novel detection technology that ... years. Now, finally, this technology is becoming commercially ...
(Date:9/30/2014)... --- Do we think of nature as something that we ... need to "preserve?" Or do we think of ourselves as ... of nature, but what about a house? , The ... also reflected in our actions, our speech and in cultural ... the University of Washington, the American Indian Center of Chicago ...
Breaking Biology News(10 mins):CARTES SECURE CONNEXIONS - Conferences & Speakers 2014 2CARTES SECURE CONNEXIONS - Conferences & Speakers 2014 3CARTES SECURE CONNEXIONS - Conferences & Speakers 2014 4First-of-a-kind Solution for Utilizing Photon Upconversion 2The cultural side of science communication 2
... annual duck hunting season in the United States is traditionally big ... for decades, the number of hunters continues to fall. Far from ... Wildlife Society Bulletin shows how the loss of revenue from ... conservation work. "The last 15 years have brought hunting opportunities ...
... German . (Jena) On their mission to the moon ... the most famous footprints ever. Since the time the astronauts of ... their footprints remain almost unchanged. And as no breath of wind ... visible forever. Not quite so old but equally ,immortal, are ...
... NY, February 7, 2013 The Vilcek Foundation is pleased ... co-winners of the 2013 Vilcek Prize for Biomedical Science. Drs. ... Medicine and investigators with the Howard Hughes Medical Institute, were ... the innate immune system. "We are pleased ...
Cached Biology News:How a fall in duck hunting is shooting a financial hole into conservation efforts 2Waste dump at the end of the world 2Waste dump at the end of the world 3Vilcek Prize for Biomedical Science split between 2 giants of immunology 2Vilcek Prize for Biomedical Science split between 2 giants of immunology 3Vilcek Prize for Biomedical Science split between 2 giants of immunology 4
(Date:10/1/2014)... BETHESDA, Md. , Oct. 1, 2014 /PRNewswire/ ... committed to the fostering and monetization of intellectual ... Spherix,s litigation against VTech and Uniden in the ... Texas has been rescheduled ... scheduled for October 2, 2014.  The Court Order ...
(Date:10/1/2014)... Irvine, CA (PRWEB) September 30, 2014 ... for user-friendly, cost-effective tools to address sales, training ... PMG has developed innovative mobile applications to ... studies, outlining the agency’s latest customized mobile app ... http://www.studiopmg.com/work . , In partnership with Toyota, ...
(Date:10/1/2014)... The U.S. Department of Labor has ... Edwardsville as part of the Trade Adjustment Assistance Community ... co-administered by the Department of Labor and Department of ... Thomas E. Perez and Secretary of Education Arne Duncan ... grants to nearly 270 colleges across the country. ...
(Date:9/30/2014)... . , Electrical ... a new kind of building block for digital integrated ... be based on three-dimensional arrangements of nanometer-scale magnets instead ... semiconductor industry CMOS fabrication of silicon chips ... the University of Notre Dame are exploring "magnetic computing" ...
Breaking Biology Technology:Markman Hearing Date for VTech and Uniden Litigation Now Set for November 10, 2014 2Digital Agency Studio PMG Launches New Case Studies on Website 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 3U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 4A new dimension for integrated circuits: 3-D nanomagnetic logic 2A new dimension for integrated circuits: 3-D nanomagnetic logic 3
... Inc. ("Company") (OTCQB: SVFC.PK) announced today that the Company has ... of Thailand, http://www.StemCells21.com . Stem Cells 21 is ... the College of Anti-ageing Medicine and a member of ... Managing Director for the Stem Cells 21.  They have ...
... University of Southern California Marshall School of Business, ranked among ... Marshall School of Business Leadership Summit to be held ... at Los Angeles, newest landmark, the JW Marriot—just steps away ... A new dynamic format will keep interest high ...
... is Preeclampsia Awareness Month and to build awareness of ... period, thousands of families in 36 cities in the ... The Preeclampsia Foundation is holding the Promise ... help provide patient support and education, raise public awareness, ...
Cached Biology Technology:IntelliCell BioSciences Signs Technology Licensing Agreement with Stem Cells 21 Thailand 2USC Marshall School of Business 6th Annual Leadership Summit 2USC Marshall School of Business 6th Annual Leadership Summit 3Preeclampsia Awareness Month Marked By Promise Walks in 36 Cities 2Preeclampsia Awareness Month Marked By Promise Walks in 36 Cities 3
Lysozyme C (W-20)...
Request Info...
Abgene's ALTO-8 is the first automated decapper/capper for Abgene Twist-Lock tubes....
... X-Gal (5-bromo-4-chloro-3-indoyl-beta-D-galactopyranoside) is a ... identify recombinant plasmids. In ... and IPTG, lac ... blue, whereas recombinant colonies ...
Biology Products: