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Researchers map spread of pathogens in the human body

into account the full evaluation of potential synergistic effects of combining drugs that can target bacteria in different body compartments. Furthermore, drug resistance can be caused, in part, by improper "blanket" use of antibiotics. As Dr. Mastroeni's more precise predictions will lead to the refined use of antibiotics, it will enable the medical field to devise more targeted treatments and to more effectively manage antibiotic drug resistance.

In the past, similar investigations have been hampered by the difficulty of identifying and observing directly the infection process within live tissues. For this study, the Cambridge researchers used advanced fluorescence microscopy techniques to observe intracellular growth of Salmonella bacteria within living cells.
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Source:University of Cambridge


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