Navigation Links
Researchers map spread of pathogens in the human body

Researchers at the University of Cambridge have discovered a new, more accurate, method of mapping how bacteria spread within the body, a breakthrough that could lead to more effective treatments and prevention of certain bacterial infections.

Dr. Pietro Mastroeni, Professor Duncan Maskell at the Centre for Veterinary Science, and their teams have pioneered the integration of mathematical models with observational data to predict the spread of individual bacteria within the human body. Their findings are reported in the November issue of PLoS Biology.

The work analyses the spread and distribution of Salmonella in the body, which is a bacterium that causes typhoid fever and food borne gastroenteritis in humans and animals, with severe medical and veterinary consequences and threats for the food industry. The work is of broad significance as these novel research approaches are applicable to a multitude of pathogenic microorganisms.

These studies indicate that individual bacteria and their progenies cleverly escape from host cells and distribute to new sites of the body, continuously staying one step ahead of the immune response. The type of spread varies between different bacteria, thus posing challenges for the rational treatment or prevention of these infections.

Some antibiotics and vaccines are better at killing bacteria outside of the cells; others are more effective at killing infections within the cells. By understanding where bacterial pathogens hide in the body and how they spread through the body's tissues, doctors will be able to decide the most effective antibiotics or vaccines to treat and prevent various types of infection.

Dr. Mastroeni said, "The fight against bacterial infections is analogous to fighting a battle, if you know where your enemy is and how it moves around, you can make calculated, strategic strikes."

Currently, the debate over the usefulness of multiple-drug therapy must take into account the full evaluation of potential synergistic effects of combining drugs that can target bacteria in different body compartments. Furthermore, drug resistance can be caused, in part, by improper "blanket" use of antibiotics. As Dr. Mastroeni's more precise predictions will lead to the refined use of antibiotics, it will enable the medical field to devise more targeted treatments and to more effectively manage antibiotic drug resistance.

In the past, similar investigations have been hampered by the difficulty of identifying and observing directly the infection process within live tissues. For this study, the Cambridge researchers used advanced fluorescence microscopy techniques to observe intracellular growth of Salmonella bacteria within living cells.
'"/>

Source:University of Cambridge


Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/16/2016)...   IdentyTechSolutions America LLC , a leading ... and a cutting-edge manufacturer of software and hardware ... seamless, integrated solutions that comprise IDT biometric readers ... provide IdentyTech,s customers with combined physical identification and ... and theft. "We are proud to ...
(Date:12/15/2016)... 2016   WaferGen Bio-systems, Inc. (NASDAQ: ... announced today that on December 13, 2016, it received ... Nasdaq Stock Market LLC which acknowledged that, as of ... common stock had been at $1.00 or greater for ... with Listing Rule 5550(a)(2) of the Nasdaq Stock Market. ...
(Date:12/15/2016)... "Increase in mobile transactions is driving the ... market is expected to grow from USD 4.03 billion ... a CAGR of 29.3% between 2016 and 2022. The ... demand for smart devices, government initiatives, and increasing penetration ... is expected to grow at a high rate during ...
Breaking Biology News(10 mins):
(Date:1/12/2017)... (PRWEB) , ... January 12, ... ... disposable devices with short response times capable of performing routine electrochemical biosensing ... disposable screen-printed electrodes provide fast, sensitive detection and quantification of various analytes ...
(Date:1/12/2017)... 2017   Protein Sciences Corporation , a ... Flublok Influenza Vaccine ®, announced today that its ... safety results and induced strong neutralizing antibodies against ... is expected to advance into human clinical trials ... Institute of Technology in Immunobiologicals of the Oswaldo ...
(Date:1/11/2017)... AURORA, Colo. (PRWEB) , ... January 11, 2017 ... ... in the journal Clinical Cancer Research show early promise of the investigational anti-cancer ... progressed despite a median 5 previous treatment regimens. Twenty-seven percent of these heavily ...
(Date:1/11/2017)... 11, 2017  Brian Mehling, M.D., world-renowned stem cell ... Horizon International (BHI), will be attending the 47th Annual ... from January 17-20, 2017. This will be Dr. ... The theme of this year,s forum is Responsive and ... will address strategies for fostering greater social inclusion and ...
Breaking Biology Technology: