Navigation Links
Researchers map of genetic variations implicated in disease

is."

The MHC Haplotype Project is creating a public resource to assist the discovery of genetic factors influencing these medical traits and to shed light on the evolution of the MHC. Access to complete sequences across several MHC haplotypes that exhibit differences in disease susceptibility will help researchers to home in on specific variants (susceptibility alleles) and to rule out regions contributing to a given disease.

Haplotypes and the MHC

Haplotypes are combinations of gene and sequence variants that tend to occur together in an individual genome. This may be purely fortuitous, or it may reflect selection of given combinations (they have been successful in the past), or it may reflect a population bottleneck, where only a few, perhaps similar, genomes have contributed to the further population growth.

The MHC is among the most gene-dense regions of the human genome and the most variable, as might be expected from a region involved in fighting infection (as well as other functions). Over evolutionary time, the MHC has been driven to become the most variable region of our genome.

The MHC Haplotype Project is studying in fine detail the sequence of eight of the most common human haplotypes, selected for conferring protection against or susceptibility to common disease. The detailed analysis of the third of these eight is reported here and compared with the two previously described.

The COX haplotype has been associated with susceptibility to a wide range of diseases, including type 1 diabetes, systemic lupus erythematosus and myasthenia gravis. The PGF haplotype provides protection against type 1 diabetes and predisposes to other diseases such as multiple sclerosis and systemic lupus erythematosus. The QBL haplotype is positively associated with Graves' disease and type 1 diabetes.


'"/>

Source:Public Library of Science


Page: 1 2 3

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researchers map genetic variations implicated disease

(Date:9/15/2014)... tropical rainforest teeming with life it,s not what comes ... the first time evidence of Doncaster,s 310-million-year-old past, including a ... mining tip. , Some of the fossilised plants and creatures ... the egg case, several horseshoe crabs and some previously unrecorded ... preserved in rocks that formed within the coal and shale ...
(Date:9/15/2014)... , , , ... , , , , ... own set of symptoms. The finding could be a first... , , ... , , , , ... , , , , , , , New research shows that schizophrenia ...
(Date:9/15/2014)... SANTA BARBARA, Calif. , Sept. 15, 2014 ... Goleta, California , announces the public ... has a very unique, patented product, combining room ... GENiSYSS is the only company to make personal ... Photo - http://photos.prnewswire.com/prnh/20140912/145664   Photo ...
Breaking Biology News(10 mins):'Jaws' lived in Doncaster 2Schizophrenia not a single disease but multiple genetically distinct disorders 2Schizophrenia not a single disease but multiple genetically distinct disorders 3Schizophrenia not a single disease but multiple genetically distinct disorders 4Schizophrenia not a single disease but multiple genetically distinct disorders 5GENiSYSS Launches Website about Easy, Inexpensive Home DNA Storage for Everyone 2
... Scientists at Barrow Neurological Institute have recently made discoveries about ... central nervous system (CNS) a finding that could have ... multiple sclerosis. The research, led by Barrow,s Fu-Dong Shi, MD, ... Journal of Experimental Medicine , and simultaneously highlighted in ...
... The availability of highly nutritious forage is one of ... in western Oregon and Washington, according to a modeling ... Service,s Pacific Northwest (PNW) Research Station. Findings from the ... planning for the ecologically and economically important ungulate in ...
... Researchers at the Swedish medical university Karolinska Institutet have been ... receptor that binds sperm at the beginning of fertilization. The ... to better understanding of infertility and may enable entirely new ... has been grasped by the encounter of gametes egg ...
Cached Biology News:Modeling study identifies characteristics of high elk-use areas in western Oregon, Washington 2
(Date:9/15/2014)... Sept. 15, 2014  FlexTech Alliance today issued ... printed product demonstrators (demos) and a functional electronic ... with pre-proposals due on October 22, 2014 and ... proposals ultimately selected are provided by the US ... cost share by the proposing organization. ...
(Date:9/15/2014)... The very idea of fibers made of carbon nanotubes is ... literally. , The single-walled carbon nanotubes in new fibers created ... through a process designed by chemist Angel Mart and his ... reported its results this month in the journal ACS ... they,re drawn together into a fiber. , Left to their ...
(Date:9/15/2014)... , Sept. 15, 2014 Zymo Research ... transport solution for safe ambient temperature storage and ... testing. Importantly, the infectivity of agents in such samples ... the integrity of the viral nucleic acids for ... recent Ebola epidemic in West Africa ...
(Date:9/15/2014)... Texas , Sept. 15, 2014 The chemistry, ... in climate, says a new article published by the nonprofit ... , PhD, on climate change and its effects on the ... of an extensive study conducted by Dr. Ahmed in the ... China and has implications for the future of ...
Breaking Biology Technology:FlexTech Alliance Issues 2015 Request for Proposals in Flexible, Printed Electronics 2Rice rolls 'neat' nanotube fibers 2Rice rolls 'neat' nanotube fibers 3Safe storage and transport of Ebola, Mers-CoV, and other viruses: Groundbreaking viral inactivation solution capable of preserving nucleic acids 2Safe storage and transport of Ebola, Mers-CoV, and other viruses: Groundbreaking viral inactivation solution capable of preserving nucleic acids 3Tea Taste and Quality Affected by Climate Change 2Tea Taste and Quality Affected by Climate Change 3Tea Taste and Quality Affected by Climate Change 4
... is now licensed to supply ISBT 128-compliant label,design and printing software ... ... and laboratories, MILWAUKEE, Aug. 28 Niceware(R) International, LLC is,excited ... to provide ISBT 128-compliant blood bag labeling,software solutions that support ISBT ...
... August 28 XTL Biopharmaceuticals,Ltd. (NASDAQ: XTLB ... in the acquisition, development and commercialization of,therapeutics for ... and hepatitis C, today announced the receipt on ... indicating that, according to the,Company,s financial statements for ...
... its ADR Listing to the NASDAQ Capital Market, ... (NASDAQ: XTLB ; LSE: XTL; TASE: XTL), ... commercialization of,therapeutics for the treatment of unmet medical ... the receipt on August 23,2007, of a NASDAQ ...
Cached Biology Technology:Niceware International Announces Licensed Vendor Status with ICCBBA, Inc. to Provide ISBT 128-compliant Software 2XTL Receives Staff Letter From NASDAQ; XTL may Transfer its ADR Listing to the NASDAQ Capital Market 2XTL Receives Staff Letter From NASDAQ; XTL may Transfer its ADR Listing to the NASDAQ Capital Market 3XTL Receives Staff Letter From NASDAQ 2XTL Receives Staff Letter From NASDAQ 3
Mouse monoclonal [SPM302] to BCAR1, prediluted ( Abpromise for all tested applications). entrezGeneID: 9564 SwissProtID: P56945...
...
p21 Ras Immunogen: Recombinant C-H-ras p21(val-12). Storage: 4 C...
Rabbit polyclonal to Myosin VIIa (rating: *****) ( Abpromise for all tested applications). entrezGeneID: 4647 SwissProtID: Q13402...
Biology Products: