Navigation Links
Researchers make surprise discovery that some neurons can transmit three signals at once

in access to these receptors has long puzzled researchers. But now, the Pittsburgh researchers believe they have solved some of the mystery. During this crucial period, immature inhibitory synapses also release the excitatory neurotransmitter glutamate, and by mimicking excitatory synapses, can stimulate NMDA receptors.

"It first appeared odd to us that an immature inhibitory synapse would want to release an excitatory neurotransmitter. After all, this contradicts the most basic principles that have defined the field of neuroscience. But when we also found that this glutamate activates NMDA receptors at the most critical stage of brain development and organization, we realized that this could explain a number of fundamental questions," explained Karl Kandler, Ph.D., associate professor of neurobiology at the University of Pittsburgh School of Medicine, and the study's senior author.

"These findings shed new light on how inhibitory synapses evolve and are assembled into functional circuits in the developing brain," he added.

Many brain disorders, like epilepsy, schizophrenia and depression, involve deficits that prevent normal inhibition of cells. Dr. Kandler's research could eventually provide insight into the biological cause of these disorders and help to identify novel approaches for prevention and treatment. Further study could have particular implications for dyslexia and tinnitus ?often referred to as ringing in the ears ?which can be caused by abnormal inhibitory signaling within the auditory system, a region of the brain that is the focus of Dr. Kandler's research.

Before there can be practical clinical applications several questions need to be answered, including how GABA, glycine and glutamate synapses cooperate to activate NMDA receptors. In the traditional sense, when inhibitory synapses are mature, they would never release glutamate, nor would they be able to depolarize a cell, both of which are required for NMDA receptor
'"/>

Source:University of Pittsburgh Medical Center


Page: 1 2 3

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
(Date:10/1/2014)... prairies and forests of the world can also be ... to a surprising new study led by Colorado State ... The research team analyzed 596 soil samples collected from ... diversity of below-ground life, most of which had never ... 16.2 percent of the organisms discovered in the park ...
(Date:9/30/2014)... the environmental effects of moorland burning is published today ... with the aim of relieving tensions on both sides ... EMBER (Effects of Moorland Burning on the Ecohydrology of ... moorland, which is practised predominantly to support red grouse ... peat hydrology, peat chemistry and physical properties, river water ...
(Date:9/30/2014)... something that we enjoy when we visit a national park ... of ourselves as a part of nature? A bird,s nest ... , The answers to these questions reflect different cultural ... and in cultural artifacts. , A new Northwestern University study, ... Center of Chicago and the Menominee tribe of Wisconsin, focuses ...
Breaking Biology News(10 mins):Microbes in Central Park soil: If they can make it there, they can make it anywhere 2Microbes in Central Park soil: If they can make it there, they can make it anywhere 3Grouse moor burning causes widespread environmental changes 2The cultural side of science communication 2
... and American researchers found the fossil remains of a whale, ... published, for the first time, the results of the decay ... young cetacean, possibly a baleen whale from the Mysticeti group. ... fossil remains of a whale from the Lower Pliocene (five ...
... consumers can look forward to ultra-low powered or self ... phones. This is made possible with power management and ... power optimisation and higher energy efficiency in electronic devices ... enabling capability for power management and energy harvesting. To ...
... The mouse is a standard laboratory model organism, ... techniques to analyze blood and blood-forming tissues in this ... easy-to-use laboratory resources from Cold Spring Harbor Laboratory Press ... step-by-step protocols for the preparation, enumeration, and microscopic examination ...
Cached Biology News:Story of 4.5 million-year-old whale unveiled in Huelva 2Story of 4.5 million-year-old whale unveiled in Huelva 3NTU and EDB launch S$50 million ($36 million) integrated circuit design research center 2NTU and EDB launch S$50 million ($36 million) integrated circuit design research center 3New source of classical techniques for blood-based studies in the laboratory mouse 2
(Date:10/1/2014)... 2014 The U.S. Department of Labor ... University Edwardsville as part of the Trade Adjustment Assistance ... is co-administered by the Department of Labor and Department ... Labor Thomas E. Perez and Secretary of Education Arne ... training grants to nearly 270 colleges across the country. ...
(Date:9/30/2014)... news release is available in German . ... the Technische Universitt Mnchen (TUM) have demonstrated a new ... experiments show that future computer chips could be based ... As the main enabling technology of the semiconductor industry ... limits, the TUM researchers and collaborators at the University ...
(Date:9/30/2014)... YORK , Sept. 30, 2014 ... to kill nematodes. Nematodes are microscopic parasitic roundworms, ... water, and inside other plants and animals. Nematicides ... volatility or other properties promoting migration through the ... more than 1,000 plant-parasitic nematodes. With more than ...
(Date:9/30/2014)... Fla. , Sept. 30, 2014 CORD:USE ... pleased to announce that it has entered into an ... Inc. (Tianhe) which has licensed a series of patented technologies ... cells for possible clinical applications.  Tianhe is performing Phase ... and Spain using Tianhe,s Stem ...
Breaking Biology Technology:U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 3U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 4A new dimension for integrated circuits: 3-D nanomagnetic logic 2A new dimension for integrated circuits: 3-D nanomagnetic logic 3Nematicides Market by Types (Fumigants, Organophosphates, Carbamate and Bio-Nematicides), Applications (Agrochemicals, Industrial, and Others), and Geography (North America, Europe, Asia-Pacific & ROW) - Global Trends & Forecasts to 2019 2CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 2CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 3CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 4
... Cellectis (Alternext: ALCLS), the French genome engineering specialist, ... (CiRA) of Kyoto University, Kyoto, Japan, have announced today ... Cellectis, genome engineering technologies with CiRA,s induced pluripotent stem ... iPS cells for use as cellular tools. ...
... Therapeutics, Inc. (Nasdaq: TSRX ) announced today that ... present "Innovative Antibacterial Drugs by Design; The Trius Therapeutics Story" ... October 26, 2010 from 5:30-9:30 p.m. PT. ... . About Trius Therapeutics ...
... International Holdings, Inc. (OTC Bulletin Board: ... medical applications and revolutionary bone graft material, today announced ... Wickwire, a distinguished Washington, D.C. based attorney and Michael ... Carparelli, to its Board of Directors.  Effective immediately, Mr. ...
Cached Biology Technology:Cellectis and the Center for iPS Cells Research and Application Enter Collaboration 2Cellectis and the Center for iPS Cells Research and Application Enter Collaboration 3Bacterin International Reconstitutes Its Board of Directors and Appoints Experienced Legal and Financial Professionals 2Bacterin International Reconstitutes Its Board of Directors and Appoints Experienced Legal and Financial Professionals 3Bacterin International Reconstitutes Its Board of Directors and Appoints Experienced Legal and Financial Professionals 4
Phosphotyrosine IgG mouse monoclonal antibody: Alkaline Phosphatase conjugate...
Rabbit polyclonal to GPCR G2A ( Abpromise for all tested applications). entrezGeneID: 29933 SwissProtID: Q9UNW8...
... has been developed for use with ... of nonspecific background staining due to ... blocking peroxidase with hydrogen peroxide. ... combination with additional novel components to ...
Rabbit polyclonal to Wilms Tumor Protein ( Abpromise for all tested applications). entrezGeneID: 7490 SwissProtID: P19544...
Biology Products: