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Researchers make nanosheets that mimic protein formation

ey created them, they weren't sure how.

"We were aware of certain proteins in living organisms that self-assemble into layers, called S-layers," Kotov said. S-layer proteins comprise the outermost cell envelope of a wide variety of bacteria and other single-celled, prokaryotic organisms called archaea, and they are able to form 2-d sheets with square, hexagonal, and other packings at surfaces and interfaces, as well as suspended in fluid. The group sought to make the connection between the forces governing S-layer protein assembly and the forces governing the nanoparticle assembly. That's when Glotzer's group, whose expertise is in computer modeling and simulation, became involved.

"It's likely that the forces between S-layer proteins are highly anisotropic, and we suspected this was also a feature of the nanoparticles," Glotzer said. "Computer simulations allowed us to further develop and test this hypothesis."

Post doctoral researcher Zhenli Zhang of Glotzer's group tried various combinations of forces based on information gleaned from experiments performed by post doctoral Zhiyong Tang of Kotov's group. The team discovered that the unique shape of the CdTe nanocrystals gave rise to a combination of forces that conspired to produce the unusual two-dimensional packing. Subsequent experiments by Kotov's group showed that if any of the forces were missing, the sheets would not form, confirming the simulation predictions.

"Self-assembly is nature's basic building principle for producing organized arrays of biomolecules with controlled geometrical and physicochemical surface properties," Glotzer said. "In the fabrication of functional nanoscale materials and devices, self-assembly offers substantial advantages over traditional manufacturing approaches, if we can design the building blocks appropriately. This is what we're trying to do."


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Source:University of Michigan


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