Researchers have identified 23 new longevity genes by screening the genome of Caenorhabditis elegans, a small worm that is used as a model organism in genetics studies. The findings are reported in the inaugural issue of PLoS Genetics.
Each of the 23 genes somehow normally acts to reduce longevity, whereas inhibiting any one of them increases lifespan. For example, the worm's lifespan doubles when one gene is prohibited from working properly, and inhibition of another gene increases the length of life by 20%.
The genes discovered affect a wide variety of activities, including insulin signaling, metabolism, and dietary regulation. Genes involved in insulin signaling are particularly interesting because corresponding human genes could potentially play a role in diabetes and cancer, according to senior author Cynthia Kenyon, of the University of California, San Francisco, and her coauthors.
Citation: Hansen M, Hsu AL, Dillin A, Kenyon C (2005) New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet 1(1): e17.
Source:Public Library of Science
Page: 1 Related biology news :1
. Researchers discover way to make cells in the eye sensitive to light2
. Researchers find how protein allows insects to detect and respond to pheromones3
. Researchers Uncover Key Step In Manufacture of Memory Protein4
. Researchers reveal the infectious impact of salmon farms on wild salmon5
. Researchers identify target for cancer drugs6
. Researchers discover molecule that causes secondary stroke7
. Researchers find missing genes of ancient organism8
. Researchers trace evolution to relatively simple genetic changes9
. Researchers add new tool to tumor-treatment arsenal10
. UF Researchers Map Bacterial Proteins That Cause Tooth Loss11
. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain