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Researchers identify neurons that assign value during learning

By using an experimental trick to activate certain sets of neurons and effectively substitute activation of these cells for positive or negative experiences, researchers have been able to identify neurons in the fruit fly Drosophila that are responsible for assigning value to stimuli during so-called associative learning. The findings, which advance our understanding of how, at the cellular level, we learn to associate cues with positive and negative experiences, are reported by Andre Fiala and colleagues at the University of W├╝rzburg in Germany and appear in the September 5th issue of Current Biology, published by Cell Press.

During associative learning, animals learn to change their behavior in response to a particular stimulus that would otherwise have a neutral influence on behavior. For example, if an animal such as a fruit fly learns to associate a particular odor with a punishing stimulus, the odor itself can become repulsive. Conversely, an odor associated with a reward can become attractive. Despite its relatively modest brain complexity, the fruit fly larva is able to perform such associative-learning tasks. Because of its neuronal simplicity and the fact that it can be genetically manipulated, the fruit fly offers a favorable study case to address a principal question in the field of learning and behavior: Which neurons attribute attractive or aversive values to so-called neutral stimuli, such as odors, in the course of associative learning?

Past work had indicated that certain neurotransmitters played key roles in assigning attractive or aversive values to neutral stimuli--for example, neurons expressing dopamine are required for aversive learning, whereas neurons expressing another neurotransmitter, octopamine, are required for appetitive learning (association of a stimulus with a reward). However, it was unclear whether a common set of neurons were responsible, or whether attractive and aversive values were assigned to neutral stimuli
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Source:Cell Press


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