Navigation Links
Researchers identify genes in fruitflies that may shed light on human cancer spread

By searching through all the genes in the fruitfly genome, Johns Hopkins scientists have identified those required for a certain type of cell migration and simultaneously captured a global view of all the genes turned on when cells are on the move.

The study, to be published April 3 in Developmental Cell, has implications for understanding cell migration and perhaps controlling cancer cells that move similarly to spread beyond an original tumor, which are what eventually kills most cancer patients.

The research identified several hundred genes that are preferentially turned on in so-called border cells of the fruitfly ovary that migrate during normal development. Two main types of genes came out of this search: those known to be involved in maintaining cell shape and structure and which become very dynamic in migrating cells; and a group of genes involved in transporting materials from the inside of a cell to its membrane surface and back again.

"So-called border cell migration shares common characteristics with metastatic cancer cells," says Xuejiao Wang, M.D., Ph.D., the first author of the study and a postdoctoral fellow in the Department of Biological Chemistry. "Cells must detach from where they are, migrate between other cells and tissues, and travel to a final destination."

Although border cell migration in the fruitfly ovary may seem a far stretch for studying human cancer metastasis, the genes uncovered in this study share more similarities with those that arise from studies of human metastatic breast cancer cells than they do with studies of other tissues in the fruitfly, according to the study's senior author, Denise Montell, Ph.D., a professor in the Department of Biological Chemistry.

The 353 genes identified in this study include some that are known to play a role in both border cell migration in fruitflies and metastasis in animal cancer cells; some that had long been suspected to play a role in cell migration, but have been more difficult to study

because their functions are shared by other genes; and some that are well understood for their roles in other cellular functions but without this study would not have been obvious candidate genes in cell migration. The results help these researchers as well as others in the field by pointing out genes to study further.

"This really was a hypothesis-generating experiment," says Montell. "The results of this study tell us where to focus future efforts."

Understanding the genetic mechanisms underlying cell migration is critical for understanding normal development, and inflammation, as well as metastasis. Classical genetic approaches for identifying key genes ?mutational analysis, for example ?have been successful but generally yield information about genes with unique functions only, and only one gene at a time. Whole genome studies, like the microarray analysis used in this study, allow researchers to identify genes that share similar functions in a way that mutational analysis cannot. And, whole genome approaches can look at most of the genes in the genome at one time.

As part of their previous work, Montell's group had generated mutant flies that show defects in border cell migration. This study identified five of the genes mutated in those flies and gives the researchers a starting point for more detailed analysis of how those genes are involved in cell migration. Wang has begun to study some of these genes to further dissect their function. The researchers also hope to perform more whole genome analyses to identify genes that interact with those already known to play a role in cell migration and metastasis.


'"/>

Source:Johns Hopkins Medical Institutions


Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. Researchers reveal the infectious impact of salmon farms on wild salmon
5. Researchers identify target for cancer drugs
6. Researchers discover molecule that causes secondary stroke
7. Researchers find missing genes of ancient organism
8. Researchers trace evolution to relatively simple genetic changes
9. Researchers add new tool to tumor-treatment arsenal
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/19/2016)... 2016 The new GEZE SecuLogic ... web-based "all-in-one" system solution for all door components. It ... the door interface with integration authorization management system, and ... The minimal dimensions of the access control and the ... installations offer considerable freedom of design with regard to ...
(Date:4/14/2016)... TEL AVIV, Israel , April 14, 2016 /PRNewswire/ ... in Behavioral Authentication and Malware Detection, today announced the ... has already assumed the new role. Goldwerger,s ... for BioCatch, on the heels of the deployment of ... In addition, BioCatch,s behavioral biometric technology, which discerns unique ...
(Date:3/31/2016)... , March 31, 2016  Genomics firm Nabsys has ... CEO, Barrett Bready , M.D., who returned to ... the original technical leadership team, including Chief Technology Officer, ... Product Development, Steve Nurnberg and Vice President of Software ... the company. Dr. Bready served as CEO ...
Breaking Biology News(10 mins):
(Date:5/27/2016)... ... ... PBI-Gordon Corporation is pleased to announce Dave Loecke has accepted the position ... PBI-Gordon, Dave has served in a wide variety of roles. His most recent position ... of many of PBI-Gordon’s most successful products. , “Dave has been essential to the ...
(Date:5/26/2016)... and READING, England , May ... http://www.indegene.com ), a leading global provider of clinical, ... and healthcare organisations and TranScrip ( http://www.transcrip-partners.com ), ... throughout the product lifecycle, today announced the extension ... IntraScience.      (Logo: http://photos.prnewswire.com/prnh/20141208/720248 ...
(Date:5/26/2016)... ... May 26, 2016 , ... FireflySci has been manufacturing quartz ... all over the globe. Their cute firefly logo has been spreading to more ... makes spectrophotometer calibration standards that never require recalibration. These revolutionary standards have ...
(Date:5/25/2016)... ... May 25, 2016 , ... ... issued by the Office of the National Coordinator for Health IT (ONC) outlining ... if clinically relevant data were available when and where it was needed. The ...
Breaking Biology Technology: